DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qin and Tdrd6

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	NP_001154838.1	Gene:	Tdrd6 / 210510	MGIID:	2679727	Length:	2135	Species:	Mus musculus

Alignment Length:	1550	Identity:	282/1550 - (18%)
Similarity:	503/1550 - (32%)	Gaps:	511/1550 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 AAIIDEFPAKDLDFLHNFSSL-DITKRNKTTEDSSDWFKTDTLVRVRSVQSPEDFYVQGIHAAQR 557
            ||...:.||::::...:..|| .|..:..|..|:          :|..|:||.:|::       |
Mouse   464 AAFQSQSPAEEMEAEVSLPSLRSIRLKMNTFYDA----------QVEFVKSPSEFWI-------R 511

  Fly   558 LREELDTFAHTLSDSSSVPPTIVVGQNYIIHHKDKD---------RYYRALVSQKLTNENLYNVF 613
            ||:..:||:.......|...:.......|:..:..|         .||||.|: :|.:::: :||
Mouse   512 LRKHKNTFSKLTKRMCSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVT-RLDSKSV-DVF 574

  Fly   614 LTDIGVHLHVRCSDFRVVPERISHLPYSAVHCSLSELMPKNGESEWDSKASAFLKQIVQNNP--V 676
            |.|.|...:|...|.|::..:...||..|:.|:|:::.|..  ..|..:|::|.|:.|.:..  |
Mouse   575 LVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLG--KTWSQEATSFFKKTVLHKELVV 637

  Fly   677 RVIVKKALTYELHGVD------------------------------------------------- 692
            .|:.|:...|.:..:|
Mouse   638 HVLDKQDHQYVIEILDESRMGEENISKVIAQAGFAKFQEFETKENIRLSAHSPGHVSGHFMAEPS 702

  Fly   693 LITS-------------NYDTNIS--VRDSFLYCGLAISRDGAPLWLPPAPTALRLPRI------ 736
            .|||             |...::|  :.|:.....|:.::|...:...|:...|...:.
Mouse   703 KITSAKKAEGDQRAKKDNKTLSVSEALADTVSLSNLSTAQDTEKVTSDPSLLMLNFLKTKPDCCG 767

  Fly   737 --SFRFGDVYMVQMLHVEDPQEFY--VMRH------------DYEKKRLWLQFSLQEAMDRINIS 785
              ....|....|::.|:|:|..|:  :||:            ||.|..   :.|..|...|:
Mouse   768 KGELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSS---EPSPYEGDTRV--- 826

  Fly   786 QLQNIFLGQLHLGCVLQ--SGGQWKRASIEQILPDGYVLVHLVDEGPSQKVFWDQLFVLPQKFWD 848
                         |:.:  :.|:|.||.|.......:|.|..||.|....|....:..:...|:.
Mouse   827 -------------CLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFFQ 878

  Fly   849 T-GLAIKCCLAD-VETRAEHSYTWTPEGTTLFKQLTSNPRLYMDVISCTEDLVYVSLHFERSNSE 911
            . ..|.:|.|.: ::...|:.:.|..:....|.....:.|.....:.||
Mouse   879 VRAQAFRCSLYNLIQPMGENPFVWDEKAVQAFSGFIDSARQNNLELKCT---------------- 927

  Fly   912 TTSVGVQLVAHGHCTSSGESSRMITPTVSNRSVRFDEETKKFIAQQKVRPVELSPYRMPD----- 971
                 |..:|..|.........::||        |....:..:.::..|||:......|.
Mouse   928 -----VFALASRHEEEWFNVVDLLTP--------FQSACRFLVEKRLARPVKHQKPLEPSVQLHS 979

  Fly   972 ---NTERNKRTTVNILYVRKPDE---FYVTLPHFQKAINNLQKSVQKAAAAMYQNMLPRTDWQVG 1030
               :|...|..:..::||...|:   ||..|......:..|..::.:.:.|:..  |..:....|
Mouse   980 YYYSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKALLN--LKASTLAPG 1042

  Fly  1031 DMCYARVQANCDSQALWYRGVVTGVIPPGITCPIVRYQVHLRDLGE---LID-------DVHSSS 1085
            .:|.||.     :...||||::....|.         :|...|.|.   .:|       |.|...
Mouse  1043 TLCLARY-----TDGNWYRGIIIEKEPS---------KVFFVDFGNTYIAVDHLLPIPRDAHDVL 1093

  Fly  1086 LANIDEADMRISSSAKRCHLHGI-RPIGDE---WSKDAIDFFMDQ-LKAYNEIHVTGRGRTENSL 1145
            |         :...|.:|.|..| ..|.:|   |.::.:   :|: |||.    |..:......:
Mouse  1094 L---------LPMQALKCSLSDIPHHIPEEVTAWFQETV---LDKSLKAL----VVAKDPDGRLI 1142

  Fly  1146 SVILWGSLSILTGPFSPATIKYVNINKALLMAGMAEKDHNSDSEDD----------------QQS 1194
            ..:...|:.|           ..:||:.|.:.|...:....:.|::                :.|
Mouse  1143 IELYDDSVQI-----------NASINEKLGLLGYKNRTRRKEKENEIILYETKALEDKKESVKPS 1196

  Fly  1195 MPENVSVNSEEAAKAND--WESCLSK----------IDGTSKTNDSLNLIESRSVTVGFEHNEDM 1247
            :.:.:|...|..|.:.:  .|||..|          :.|::|.    ||:.....:||.:::...
Mouse  1197 LADYLSKPGESKAHSVEIMGESCKPKMGPACKELRYLQGSAKA----NLVPPYQDSVGNKNDGGF 1257

  Fly  1248 P-------PLALLEDLGNTK-----------NTTGETTPPAGWTTRRKCD---KSVFTAIATNVT 1291
            |       .:.....:..||           ..:|...||      :.|:   |::.....|:|
Mouse  1258 PLTREKKEDIFASSPMSGTKLDSALPERRMGEPSGRDLPP------KFCEFPQKTIAPGFKTSV- 1315

  Fly  1292 YECCI------YLTLASDKPFIEHMGNLL--VREYKPLMDKQKERSTSYTYKVGQAVVVTYHMDN 1348
            |...|      |:.|..|:..|.::...|  ||       .:.:..|...::.|..:...:..||
Mouse  1316 YVSHINDLSDFYIQLIEDEAEINNLSERLNDVR-------TRPQYHTGPQWQSGDVICAVFPEDN 1373

  Fly  1349 MIYRGIVQRLENNHNEYTVYYVDYGNMELVKADEMLPYAPFPDLNAMCFLVELHGVRSKQGKYSL 1413
            :.||.:|...:.| ...:|.::|||||.:
Mouse  1374 LWYRALVMEQQPN-GLLSVQFIDYGNMSV------------------------------------ 1401

  Fly  1414 KEMDTVHLNLVMKLSGVRIVDDETVGPNKIPKCQIKVGNVDIATMMIDSGMSVPIEKQTIKNNTK 1478
                 ||.|...:|..|     :.|.|.....|.:             .|:|||:.|:.:...::
Mouse  1402 -----VHTNRTGRLGPV-----DAVLPALCLHCSL-------------WGLSVPVCKEMVSYFSQ 1443

  Fly  1479 YLPSQKFLEDFKVFDELDHLAAGEGELSDKEAPPTQRKHDSISSVQQPPTKKFLVDQEEVEAFEC 1543
            .....:...:|..|.     ...|..|:|:..                     ::.::.:..|.|
Mouse  1444 RTDEAQIRCEFVKFQ-----GTWEVILADEHG---------------------VIAEDMISRFPC 1482

  Fly  1544 DQDFDCQQAAQKMHLNNNFYLGDFGKYADETTARDEDEPHSNSSKSIDMEVFANVNDSQLEPLNS 1608
            :.:.......|.|.       ||..|.|::..|              |..|..|..:.:.:.:.:
Mouse  1483 NGNSQAGLTTQTMK-------GDCLKIANKPNA--------------DTSVLLNWYNPKAKLIKA 1526

  Fly  1609 FATEQLIRRIALRQQEIKDSITFSPIDTSSVRSFYDASASFKTLSLPNGVKEFYCTVDNVLSDTE 1673
            :||                                          :.:|.:.|:|
Mouse  1527 YAT------------------------------------------VIDGPEYFWC---------- 1539

  Fly  1674 LQIAPCLSEFTKHEISLIQETSTLIKDAEPLME-PKVGDLCLARYSRDKQWYRANIKEISPILSP 1737
             |.|.  ||..::..:.:|.....:.|.....: |::||.|:.||..|..:|||.|..|.
Mouse  1540 -QFAD--SEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYREDGHYYRALITNIC----- 1596

  Fly  1738 TSEQVTVFYIDFHDTEK-VSFNHLKVMPSQLFMFPLRSFCVKLHGI---------KRNKSFKEKS 1792
            ..|..:|..:||.:.|. |....|..:||:|.:.|:::|...|.|.         :.|..|.:..
Mouse  1597 DGELASVRLVDFGNAEDCVDAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYFYDIV 1661

  Fly  1793 VRQALQACLCQHPLVFARVHYPLNYYPNRPNCDADLIEVELY---ENRHEKKLVY 1844
            ....|...:.:               ..|..|:..|..|||.   ||.:||...|
Mouse  1662 TEDVLDITILE---------------IKRDVCNIPLAIVELRSKGENINEKMKKY 1701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965	31/120 (26%)
		TUDOR	741..859	CDD:278965	30/134 (22%)
		TUDOR	<805..839	CDD:119391	11/33 (33%)
		TUDOR	981..1107	CDD:278965	28/138 (20%)
		TUDOR	1296..1403	CDD:278965	22/114 (19%)
		TUDOR	1337..1385	CDD:119391	13/47 (28%)
		TUDOR	1710..1761	CDD:119391	17/51 (33%)
Tdrd6	NP_001154838.1	TUDOR	10..133	CDD:278965
		TUDOR	245..379	CDD:278965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..315
		TUDOR	313..359	CDD:119391
		TUDOR	489..610	CDD:278965	34/139 (24%)
		TUDOR	547..591	CDD:119391	14/45 (31%)
		TUDOR	773..890	CDD:278965	30/135 (22%)
		TUDOR	826..869	CDD:119391	12/58 (21%)
		TUDOR	987..1106	CDD:278965	29/143 (20%)
		TUDOR	1042..1084	CDD:119391	13/55 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1296		3/24 (13%)
		TUDOR	1309..1428	CDD:278965	33/186 (18%)
		TUDOR	1362..1406	CDD:119391	15/85 (18%)
		TUDOR	1519..1641	CDD:278965	36/181 (20%)
		TUDOR	1574..1621	CDD:119391	17/51 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1699..1733		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1860..1885
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1930..1987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43916
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810