DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qin and TDRD5

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	NP_001186014.1	Gene:	TDRD5 / 163589	HGNCID:	20614	Length:	1035	Species:	Homo sapiens

Alignment Length:	905	Identity:	166/905 - (18%)
Similarity:	303/905 - (33%)	Gaps:	302/905 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   599 LVSQK--LTNENLYNVFLTDIGVHLHVRCSDFRVVPERISHLPYSAVHCSLSELMPKNGESEWDS 661
            |:|.|  |:.:.|...:|..:|.||.:|...:|...|.:..:|      .:..:.|..|.:
Human    19 LISTKDGLSPQELEKEYLLMVGNHLPLRILGYRSTMELVLDMP------DVVRVCPGAGGT---- 73

  Fly   662 KASAFLKQIVQNNPVRVIVKKALTYELHGVDLITSNYDTNISVRDSF------LYCGLAISRDGA 720
                            ||:|........|:..:.:...::..:|:|.      :|.|
Human    74 ----------------VILKAIPDESTKGIASLVAKQRSSHKLRNSMHKGRPSIYSG-------- 114

  Fly   721 PLWLPPAPTALRLPRISFRFGDVYMVQMLHVEDPQEFY-----VMRHDYEK---KRL-----WLQ 772
                   |.:.|  |:.:| |.|..:....|:...:..     |:..|:||   ||.     ::|
Human   115 -------PRSHR--RVPYR-GRVAPILPAVVKSELKDLLALSPVLLSDFEKAFAKRFGRSFQYMQ 169

  Fly   773 FSLQEAMDRINISQLQNIFLGQLHLGCVLQSGGQWKRASIEQILPDGYVLVHLVDEGPSQKVFWD 837
            :......:.:|.:. ..|.:.|...|.:|.     .:.|:.:..|.|.         |:.|:| .
Human   170 YGFLSMFEVLNAAS-DVISVEQTRAGSLLM-----LKKSVTEEKPRGC---------PAGKIF-T 218

  Fly   838 QLFVLPQKFWDTGLAI-KCCLAD----------------------VET-RAEHS----------- 867
            |.|.:.|..:.||..: |.|.:.                      ||| |..|:
Human   219 QPFRMKQGSYSTGFPVAKPCFSQPTSNMEPPKQIMSMEKTSKLNVVETSRLNHTEKLNQLENTFK 283

  Fly   868 -----------------------YTWTPEG----------TTLFKQLTSNPRL----YMDVISCT 895
                                   .:..|||          ..:||:..|..:|    ..:::...
Human   284 SVIAQIGPGGTISSELKHKIKFVVSKFPEGLFISKLLGEYEVIFKEQLSPKKLGFLNVTELVGAL 348

  Fly   896 EDLVYVS--------LHFERSNSETTSV-GVQLVAHGHCTSS----GESSRMITPTVSNRSVRFD 947
            .|:::|.        |.|:........| ..:.:....|.||    ..|:..:..||.|...:..
Human   349 SDILHVEFRKGHQDLLVFDADKKPLPPVQSDKKIEAKACVSSPPRNSLSTAAVKETVWNCPSKKQ 413

  Fly   948 EETKKFIAQQK---VRPVEL-------------SPYRMPDNTERNKRTT------------VNIL 984
            :|.::.|.::.   |:|::|             :.:.:|.:...||:..            |.:.
Human   414 KEPQQKICKKPNLVVKPLQLQVETNKSELNLAMANHDIPPDAVPNKKLCRLPPLDTSSLIGVFVE 478

  Fly   985 YVRKPDEFYVTLPHFQKAINNLQKSVQKAAAAMYQNML-------PRTDWQVGDMCYARVQANCD 1042
            |:..|.:||:.:  :.:..:.|.:.:.......|.|.|       |....|.|.:|..|:    .
Human   479 YIISPSQFYIRI--YSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVRI----S 537

  Fly  1043 SQALWYRGVVTGVIPPGITCPIVRYQVHLRDLGELIDDVHSSSLANIDEADMRISSSAKRCHLHG 1107
            ....|||.::..|:..      ...:|...|.|. |..|..|||..:.....::.:.|..|.|..
Human   538 EDKWWYRVIIHRVLEK------QEVEVFYPDFGN-IGIVQKSSLRFLKCCYTKLPAQAIPCSLAW 595

  Fly  1108 IRPIGDEWSKDAI----------------DFFMDQL-------KAYNE---IH------------ 1134
            :||:.:.|:..||                |.::|.:       .:.||   .|
Human   596 VRPVEEHWTSKAILQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVC 660

  Fly  1135 ---VTGRGRTE-NSLSVILWGSLS----ILTGPFSPATIKYVNINKALLMAGMAEKDHNSDSE-- 1189
               ::.:|.:| |.|::....|..    :||....|:...|.|.::.:       ...:.:||
Human   661 RENISSKGFSELNPLALYTTSSGGPEDIVLTELGYPSQQHYFNEDRKI-------SPQSKESELR 718

  Fly  1190 -----DDQQSMPENVSVNSEEAAKANDWES---CLSKIDGTSK-TNDSLNLIESRSVTVGFEHNE 1245
                 :|::|: .::...|:|..|.:::||   |....:...| :|...|.::        |.||
Human   719 ILQDINDEKSL-SHLKSESKEPLKDSEFESLKTCNKSFEEDPKWSNPEPNDLK--------EENE 774

  Fly  1246 DMPPLAL--LEDLGNTKNTTGETTPPAGW-TTRRKCDKS------VFTA-IATNVTYECC 1295
            |..|..:  ||.:     |.|:......| ..:.|..|.      :||| :.....|..|
Human   775 DEIPTGMPCLESV-----TIGDDIWDENWLPLQAKMGKGGDAASHLFTASLGGKNQYSSC 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965	13/50 (26%)
		TUDOR	741..859	CDD:278965	28/131 (21%)
		TUDOR	<805..839	CDD:119391	6/33 (18%)
		TUDOR	981..1107	CDD:278965	29/132 (22%)
		TUDOR	1296..1403	CDD:278965	166/905 (18%)
		TUDOR	1337..1385	CDD:119391
		TUDOR	1710..1761	CDD:119391
TDRD5	NP_001186014.1	LOTUS_1_TDRD5	4..98	CDD:193599	19/104 (18%)
		LOTUS_2_TDRD5	132..201	CDD:193589	13/74 (18%)
		LOTUS_3_TDRD5	296..369	CDD:193590	11/72 (15%)
		TUDOR	471..594	CDD:278965	28/135 (21%)
		TUDOR	529..575	CDD:119391	14/56 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740