DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qin and TDRD10

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	XP_011507454.1	Gene:	TDRD10 / 126668	HGNCID:	25316	Length:	398	Species:	Homo sapiens

Alignment Length:	382	Identity:	69/382 - (18%)
Similarity:	120/382 - (31%)	Gaps:	152/382 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   864 AEHSYTWTPEGTTLFKQLTSNPRLYMDVISCTEDLVYVSLHFERSNSETTSVGVQLVAHG-HCTS 927
            ||..|.|       |.|.:..           |:::|:...|       ..:.|..:.:| .|.:
Human    66 AEEPYMW-------FLQWSGE-----------EEILYLLKDF-------NPLDVHKIQNGCKCFA 105

  Fly   928 SGE--SSRMITPTVSNRSVRFDEETKKFIAQQKVRP----------------------------- 961
            ..:  |.:.:|..:...:.:...:.|.|:...|..|
Human   106 FVDLGSMQKVTLAIQELNGKLFHKRKLFVNTSKRPPKRTPDMIQQPRAPLVLEKASGEGFGKTAA 170

  Fly   962 -VELSPYRMPDNTERNK------------RTTVNILYVRK--PDEFYVTLPHFQKAINNLQKSVQ 1011
             ::|:|....|..|..|            |.:..:|.:|:  .|..::.|.|          ||:
Human   171 IIQLAPKAPVDLCETEKLRAAFFAVPLEMRGSFLVLLLRECFRDLSWLALIH----------SVR 225

  Fly  1012 KAAAAMYQNMLPRTD--W--QVGDMCYARVQ------ANCDSQALWYRGVVTGVIPPGITCPIVR 1066
            ..|..:..:::|:|.  |  .|.:..:..:|      |..:.|..:..|   ..:..|..| :..
Human   226 GEAGLLVTSIVPKTPFFWAMHVTEALHQNMQALFSTLAQAEEQQPYLEG---STVMRGTRC-LAE 286

  Fly  1067 YQVHLRDLGE------LIDDVHS---------SSLANIDEADMRISSSAKRCHLHGIRPIGDEWS 1116
            |  ||.|.|.      ::|.|.:         ..||.|....:|                    |
Human   287 Y--HLGDYGHAWNRCWVLDRVDTWAVVMFIDFGQLATIPVQSLR--------------------S 329

  Fly  1117 KDAIDF---------FM---DQLKAYNEIHVTGRGRTENSLSVILWGSLSILTGPFS 1161
            .|:.||         ||   |.|.:|..:|...:|:...:|:       |.:|.|.|
Human   330 LDSDDFWTIPPLTQPFMLEKDILSSYEVVHRILKGKITGALN-------SAVTAPAS 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965
		TUDOR	741..859	CDD:278965
		TUDOR	<805..839	CDD:119391
		TUDOR	981..1107	CDD:278965	29/152 (19%)
		TUDOR	1296..1403	CDD:278965
		TUDOR	1337..1385	CDD:119391
		TUDOR	1710..1761	CDD:119391
TDRD10	XP_011507454.1	RRM	<7..>135	CDD:223796	16/93 (17%)
		RRM_SF	77..134	CDD:302621	9/74 (12%)
		TUDOR	<251..347	CDD:278965	22/121 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100