DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qin and Akap1

DIOPT Version :9

Sequence 1:	NP_650735.3	Gene:	qin / 42236	FlyBaseID:	FBgn0263974	Length:	1857	Species:	Drosophila melanogaster
Sequence 2:	NP_446117.1	Gene:	Akap1 / 114124	RGDID:	620826	Length:	854	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	81/430 - (18%)
Similarity:	140/430 - (32%)	Gaps:	91/430 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 KLNDYATETLASISKRFSHLHGLLQVAELQVIEKLRESSLP-PQLKLNEAMGQLSGYETVIERLT 345
            :|.|..|||::|...:             .|...|.:|:.| ....|.|.:..| |.|......|
  Rat   466 RLEDSCTETISSSGDK-------------AVTPPLPDSTEPFSNGVLKEELSDL-GTEDGWTMDT 516

  Fly   346 KSLNSG--VGNDM-AVPRDVSLRWLLKLICEHLEKIPTTVQVSKVDENPYRVTCSRFMDISNIFK 407
            ::.:||  .||.| :|..           |..|.| |.:.|..:...||.:|....:
  Rat   517 EADHSGGSDGNSMDSVDS-----------CCGLTK-PDSPQTVQAGSNPKKVDLIIW-------- 561

  Fly   408 CEFVNPNIQVCFKTDLEISRSLSSSPKGE----ITFLTSSSSSKENFD--PHSRKLLLAQNSKLK 466
                          ::|:.:.|.....|:    ::||..:|.:|....  |:::.:.:..
  Rat   562 --------------EIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICH----- 607

  Fly   467 KATQVSQSQKKRGKNATEVAQSSLNSTAAIIDEFPAKDLDFLHNFSSLDITKRNKTTEDSSDWFK 531
              .:.||....:..|........||.|.......|:..|      .||.:|          .|..
  Rat   608 --IEGSQHHVDKALNLIGKKFKELNLTNIYAPPLPSLAL------PSLPMT----------SWLM 654

  Fly   532 -----TDTLVRVRSVQSPEDFYVQGIHAAQRLREELDTFAHTLSDSSSVP--PTIVVGQNYIIHH 589
                 |..::.|..|.:...|..|..|........||...:.......:|  ||.|.........
  Rat   655 LPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAP 719

  Fly   590 KDKDRYYRALVSQKLTNENLYNVFLTDIGVHLHVRCSDFRVVPERISHLPYSAVHCSLSELMPKN 654
            .....::||.|.......|...:...|.|.:..|:....|.:......||:......|..::|.:
  Rat   720 GADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVVPLS 784

  Fly   655 GESEWDSKASAFLKQIVQNNPVRVIVKKALTYELHGVDLI 694
            .:..:..:|.|.:.::..|.   .::.:..:|...|:.||
  Rat   785 DDDHFSPEADAAMSEMTGNT---ALLAQVTSYSATGLPLI 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qin	NP_650735.3	zf-RING_5	25..75	CDD:291308
		BBOX	139..174	CDD:197662
		TUDOR	536..648	CDD:278965	21/113 (19%)
		TUDOR	741..859	CDD:278965
		TUDOR	<805..839	CDD:119391
		TUDOR	981..1107	CDD:278965
		TUDOR	1296..1403	CDD:278965
		TUDOR	1337..1385	CDD:119391
		TUDOR	1710..1761	CDD:119391
Akap1	NP_446117.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..115
		PKA-RII subunit binding domain	303..316
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..437
		HNF-1_N	394..>510	CDD:282645	14/57 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..495		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..551		13/53 (25%)
		KH-I	562..622	CDD:238053	11/66 (17%)
		TUDOR	655..777	CDD:278965	22/121 (18%)
		TUDOR	707..765	CDD:197660	11/57 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010