DRSC/TRiP Functional Genomics Resources

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Protein Alignment qin and notch3

DIOPT Version :10

Sequence 1:NP_650735.3 Gene:qin / 42236 FlyBaseID:FBgn0263974 Length:1857 Species:Drosophila melanogaster
Sequence 2:XP_017948007.1 Gene:notch3 / 100494244 XenbaseID:XB-GENE-6450008 Length:2413 Species:Xenopus tropicalis


Alignment Length:1307 Identity:232/1307 - (17%)
Similarity:409/1307 - (31%) Gaps:407/1307 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 LGCGHTLCES---CLWNDRLDPKCAVC------------HSPAPPTIVAKRSDCKS----VANLR 96
            |.|....|.|   || ...|.|:| :|            .:|.|..:....|.|::    :.|:.
 Frog  1317 LSCRELSCPSGSTCL-PPPLGPRC-ICPPGVLCRTPNNSSAPTPAPLPCSNSPCRNGATCIPNIH 1379

  Fly    97 -DLYELNYH--VLG-----RTSSLSYLLPFAKDSANQSLSPSSISEIVQTVKC--SECGNATASG 151
             ..|:...|  ::|     ||..:          ..|:.:|.          |  |.|......|
 Frog  1380 FPYYQCKCHPGMIGPRCDIRTPRI----------LTQTPAPG----------CTPSHCPGKAGDG 1424

  Fly   152 EC-RQCNAFYCR----RCFDAVHKRSRVLKSHIFRNSTEQD-------SSFSKKLRVGDQYFTLP 204
            .| |:||...|:    .|..:|        ...:||...|:       |...|:....|      
 Frog  1425 HCDRECNVAACKWDGGDCSLSV--------DDPWRNCPRQECRSLFNNSQCDKECTSAD------ 1475

  Fly   205 SQNLCIHH----RMPKDKYCMKCYRSHCQICSTVHHSGHRIRKLIEINQSYASEIPTTLNSLNMA 265
                |::.    |..:::.|...|..:|.    .|:...|..|.....:.....:....||    
 Frog  1476 ----CLYDNFDCRGREERSCNPVYEKYCM----DHYGDGRCDKGCNSEECGWDGLDCAKNS---- 1528

  Fly   266 HIHVLNGKQVVQRAKQKLNDYATETLASISKRFSHLHGLLQVAE----LQVIEKLRESSLPPQLK 326
            ...||....:|.......|::..::.|.:.:..|.||..|:...    ...|:..|:|......|
 Frog  1529 DKEVLADGVLVVVVLVPPNEFLKQSTAFLQRLSSLLHTSLRFCTDSNGNYKIKPYRKSQTWDGRK 1593

  Fly   327 LNEAMGQLSGYETVIERLTKSLNSGVGNDMAVPR--------DVSLRWLLKL-ICEHLE-----K 377
            ..|....:.|.|.::|         :.|.:.|..        :.:.|:|..| :.|.|:     |
 Frog  1594 KRELDSDIIGSEVMLE---------IDNRICVKEMPDCFPNTETAARFLAALSVLERLQFPYPIK 1649

  Fly   378 IPTTVQVSKVDENPYRVTCSRFMDISNIFKCEFVNPNIQVCFKTDLEI-------SRSLSSSPKG 435
            ...:.::.:|.:|      .||:.:       |....:.:.....|.:       :.|....|:|
 Frog  1650 AVRSEKIEEVIDN------FRFLPL-------FAVAGVLILIVAVLGVIVSRRKRAHSTLWFPEG 1701

  Fly   436 EITFLTSSSSSKENFDPHSRKLL----LAQNSKLKK-------ATQVSQSQKKRGKNATEVAQSS 489
            .|.     ...::..:|..:..|    :|:..:|.:       .|...:::|.:.:..:...|..
 Frog  1702 FIL-----KKERDRREPVGQDALGLKNIAKAERLMEDPSEDWTETDCPETKKLKTEELSPCRQDP 1761

  Fly   490 LNSTAAIIDEFPAKDLDFLHNFSSLDITKRNKT--TEDSSDWFKTDTLVRVRSVQSPEDF----- 547
                   :|..|...    |:.::.||.....|  |....|:......|.||   .|:.|     
 Frog  1762 -------VDPRPWTQ----HHLAAADIRLPPATALTPPQGDYESDGMDVNVR---GPDGFTPLML 1812

  Fly   548 --YVQGIHAAQRLREELDTFAHTLSD-----SSSVPPTIVVGQNYIIHHKDKDRYYRALVSQKLT 605
              ::.|....:...||.:..|..::|     :|....|...|:..:  |. ..||.||..:::  
 Frog  1813 ASFLGGGLEPESQEEEEEGEASAITDLICQGASLGAQTDRTGETAL--HL-AARYARADAAKR-- 1872

  Fly   606 NENLYNVFLTDIGVHLHVRCSDFRVVPERISHLPYSAVHCSLS-------ELMPKNGESEWDSKA 663
                    |.|.|..           |....|...:.:|.:::       :::.:|..::.|:: 
 Frog  1873 --------LLDAGAD-----------PNAQDHTGRTPLHAAVAADAQGVFQILIRNRSTDLDAR- 1917

  Fly   664 SAFLKQIVQNNPVRVIVKKALTYELHGVDLITSNYDTNI--SVRDSFLYCGLAISRDGAPLWLPP 726
                   :.:....:|:...|..|....:|||.:.|.|.  .:..|.|:...|::...|.|.|  
 Frog  1918 -------MGDGSTALILAARLAVEGMVEELITCHADVNAVDELGKSALHWAAAVNNIEATLAL-- 1973

  Fly   727 APTALRLPRISFRFGDVYMVQMLHVEDPQEFYVMRHDYEKKRLWLQF----SLQEAMDRINISQL 787
                       .:.|....:|....|.|.........||..::.|..    .:.:.|||:.    
 Frog  1974 -----------LKNGANKDMQDSKEETPLFLAAREGSYEAAKVLLDHYANREITDHMDRLP---- 2023

  Fly   788 QNIFLGQLHLGCVLQSGGQWKRASIEQILPDGYVLVHLVDEGPSQKVFWDQLFVLPQKFWDTGLA 852
            ::|...:||             ..|.|:|.:...:.:  .:||........|...|..|..    
 Frog  2024 RDIAQERLH-------------HDIVQLLEEHNTVRN--SQGPMGGHTMSPLLCPPNGFMG---- 2069

  Fly   853 IKCCLADVETRAEHSYTWTPEGTTLFKQLTSNPRLYMDVISCTEDLVYVSLHFERSNSETTSVGV 917
                          |...||:|.   |...:|.:.....:|..|            ..:....|.
 Frog  2070 --------------SVKQTPQGK---KNRRANAKANGASLSRAE------------AKDAKGRGK 2105

  Fly   918 QLVAHGHCTSSG--ESSRMITPTVSNRSVRFDEETKKFIAQ--QKVRPV----ELSPYRMPDNTE 974
            :|....|..|.|  |||..::|..|..|.|      .:.|.  ..|.||    .|....:|..  
 Frog  2106 KLSLDCHPGSGGLLESSVTLSPVDSLDSPR------AYSANPGSPVMPVPGTFNLGSMSVPST-- 2162

  Fly   975 RNKRTTVNILYVRKPDEFYVTLPHFQKAINNLQKSVQKAAAAMYQNMLP---RTDWQVGDMCYAR 1036
                ..||.| :..|  |.|:|..    :|.|.: :|.......|..:|   .....|..:....
 Frog  2163 ----PLVNGL-MEGP--FAVSLAR----LNELGE-IQGGGMMALQGRVPLQRAPSCVVNGLNLGM 2215

  Fly  1037 VQANCDSQALW---------YRGVVTGVIPPGITCPIVRYQVHLRDLGELIDDVHSSSLANIDEA 1092
            |..|. ...:|         :|.|:||.  |..:.|.: :|:|.:.:..|             :.
 Frog  2216 VNTNA-MPFIWQTGVPTSHPHRNVMTGA--PAASVPNL-HQLHAQQVLML-------------QN 2263

  Fly  1093 DMRISSSAK-----RCHLHGIRPIGDEWSKDAIDFFMDQLKAYNEIHVTGRGRTENSLSVILWGS 1152
            .|.:.|..|     :|.:..:.|                    |.:|:     .:.|:..:...|
 Frog  2264 QMAMQSPVKMAMDQQCQMVSMPP--------------------NPVHM-----RQQSMPHVAERS 2303

  Fly  1153 LSILTGPFSPATIKYVNINKALLMAGMAEKDHNSDSEDDQQSMPENVSVNSEEAAKANDWESCLS 1217
            :.    |.:|....|..                      |||:|.:|::.:..|..|...::...
 Frog  2304 VQ----PLTPTEGSYFK----------------------QQSVPNDVTMQTSPAMSAPPQQTFAP 2342

  Fly  1218 KIDGTSK 1224
            ..:.|.|
 Frog  2343 SQEDTPK 2349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
qinNP_650735.3 zf-RING_5 25..76 CDD:434085 10/39 (26%)
Bbox1 140..178 CDD:380815 11/44 (25%)
Bbox2 208..244 CDD:380814 7/39 (18%)
TUDOR 536..648 CDD:425754 24/123 (20%)
TUDOR 742..859 CDD:425754 20/120 (17%)
Tudor_SF 989..1139 CDD:470623 29/166 (17%)
TUDOR 1296..1403 CDD:425754
TUDOR <1703..1781 CDD:425754
notch3XP_017948007.1 EGF_CA 105..139 CDD:238011
EGF_CA 142..179 CDD:238011
EGF_CA 220..256 CDD:238011
EGF_CA 258..295 CDD:238011
EGF_CA 298..333 CDD:238011
EGF_CA 375..413 CDD:238011
EGF_CA 415..451 CDD:238011
EGF_CA 453..489 CDD:238011
EGF_CA 491..526 CDD:238011
EGF_CA 529..564 CDD:238011
EGF_CA 567..602 CDD:238011
EGF 726..756 CDD:394967
EGF_CA 760..796 CDD:238011
EGF_CA 838..874 CDD:238011
EGF_CA 876..912 CDD:238011
EGF_CA 915..950 CDD:238011
EGF_CA 952..988 CDD:238011
EGF_CA 991..1026 CDD:238011
EGF_CA 1029..1063 CDD:238011
EGF_CA 1115..1150 CDD:238011
EGF_CA 1152..1188 CDD:238011
EGF_CA 1190..1232 CDD:238011
EGF_CA 1234..1272 CDD:238011
EGF_CA 1276..1313 CDD:238011
Notch 1410..1443 CDD:459658 10/42 (24%)
Notch 1450..1484 CDD:459658 7/43 (16%)
Notch 1498..1524 CDD:459658 4/29 (14%)
NOD 1531..1584 CDD:462014 10/52 (19%)
NODP 1601..1658 CDD:462229 11/65 (17%)
JMTM_Notch3 1640..1726 CDD:411987 15/103 (15%)
ANK repeat 1805..1851 CDD:293786 7/45 (16%)
ANKYR 1833..2056 CDD:440430 50/286 (17%)
ANK repeat 1853..1884 CDD:293786 10/54 (19%)
ANK repeat 1887..1918 CDD:293786 3/38 (8%)
ANK repeat 1920..1951 CDD:293786 8/30 (27%)
ANK repeat 1953..1984 CDD:293786 7/43 (16%)
ANK repeat 1986..2017 CDD:293786 5/30 (17%)
Atrophin-1 2262..>2403 CDD:460830 21/139 (15%)
Blue background indicates that the domain is not in the aligned region.

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