Protein Alignment Tssk and Sik1

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_067725.2
• Gene: Sik1 / 59329
• RGDID: 69407
• Length: 776
• Species: Rattus norvegicus
• Alignment Length: 282
• Identity: 89/282 - (31%)
• Similarity: 154/282 - (54%)
• Gaps: 18/282 - (6%)

  Fly    14 GTRSSDVDALAQRGYNVGHKIGEGSYATVITAGYADDHGHGV---HLACKIIDKAKAPTDFVNKF 75
            ||.......|....|:|...:|:|::|.|..|      .|.|   .:|.|||||.:..:..:.|.
  Rat    13 GTGQGQQKPLRVGFYDVERTLGKGNFAVVKLA------RHRVTKTQVAIKIIDKTRLDSSNLEKI 71

  Fly    76 FPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIWFFQMSK 140
            : ||::::..::|.|||:::.:::....::|...:|:||::..::..:|.:.|.:::..|:|:..
  Rat    72 Y-REVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILS 135

  Fly   141 ALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETYCGSAAYAAPEVVC 205
            |::|.||..|.|||||.||:||...::||||||||..:.:.  |..:  .|:|||..||||||..
  Rat   136 AVEYCHNHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKP--GEPL--STWCGSPPYAAPEVFE 196

  Fly   206 GRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETISAQAKATVSV 270
            |:.|:....|.|||||:|::::...:|||..||..|    |.|....|.::...:|...:..:..
  Rat   197 GKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTL----RQRVLEGRFRIPFFMSQDCETLIRR 257

  Fly   271 LLEPEAHARWNLREILNCAWLR 292
            :|..:...|..:.:|....|::
  Rat   258 MLVVDPAKRITIAQIRQHRWMQ 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	85/266 (32%)
Sik1	NP_067725.2	STKc_SIK	26..278	CDD:270973	85/266 (32%)
		UBA_SIK1	300..349	CDD:270591
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..371
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..472
		RK-rich region. /evidence=ECO:0000250	586..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..643