Protein Alignment Tssk and MARK4

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_001186796.1
• Gene: MARK4 / 57787
• HGNCID: 13538
• Length: 752
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 93/294 - (31%)
• Similarity: 156/294 - (53%)
• Gaps: 18/294 - (6%)

  Fly    11 RQLGTR-SSDVDALAQRGYNVGH-----KIGEGSYATVITAGYADDHGHGVHLACKIIDKAKAPT 69
            |.||.| .:.:.:..:...:||:     .||:|::|.|..|.:...   |..:|.|||||.:...
Human    36 RSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILT---GREVAIKIIDKTQLNP 97

  Fly    70 DFVNKFFPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIW 134
            ..:.|.| ||:.|:..::|.||:::..:::....:::.|.||..|::..::...|.:.||:::..
Human    98 SSLQKLF-REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAK 161

  Fly   135 FFQMSKALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETYCGSAAYA 199
            |.|:..|:.|.|..:|.|||||.||:||....|||:|||||:    ::.....|.:|:|||..||
Human   162 FRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFS----NEFTLGSKLDTFCGSPPYA 222

  Fly   200 APEVVCGRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETISAQA 264
            |||:..|:.||....|.|||||||:.:::..:|||..||.:|    |.|....:.::...:|...
Human   223 APELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKEL----RERVLRGKYRVPFYMSTDC 283

  Fly   265 KATVSVLLEPEAHARWNLREILNCAWLRTVEESQ 298
            ::.:...|......|..|.:|:...|:....|.:
Human   284 ESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGE 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	87/268 (32%)
MARK4	NP_001186796.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		93/294 (32%)
		STKc_MARK	58..310	CDD:270974	85/263 (32%)
		UBA_MARK3_4	328..370	CDD:270590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..614
		MARK4_C	654..752	CDD:213382