Protein Alignment Tssk and PRKAA2

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_006243.2
• Gene: PRKAA2 / 5563
• HGNCID: 9377
• Length: 552
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 86/267 - (32%)
• Similarity: 139/267 - (52%)
• Gaps: 15/267 - (5%)

  Fly    28 YNVGHKIGEGSYATVITAGYADDHGHGVHLACKIIDKAKAPT-DFVNKFFPRELEILTKIDHSNI 91
            |.:|..:|.|::..| ..|.....||.|  |.||:::.|..: |.|.| ..||::.|....|.:|
Human    16 YVLGDTLGVGTFGKV-KIGEHQLTGHKV--AVKILNRQKIRSLDVVGK-IKREIQNLKLFRHPHI 76

  Fly    92 IQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIWFFQMSKALKYLHNLDIAHRDLK 156
            |:::.::......|:.|.|...|:|..:|.:.|.::|.:::..|.|:..|:.|.|...:.|||||
Human    77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141

  Fly   157 CENILLSKRLNIKLADFGFARYCRDDNGREMKSETYCGSAAYAAPEVVCGRPYDPKLADAWSLGV 221
            .||:||...:|.|:||||.:....|  |..::  |.|||..||||||:.||.|.....|.||.||
Human   142 PENVLLDAHMNAKIADFGLSNMMSD--GEFLR--TSCGSPNYAAPEVISGRLYAGPEVDIWSCGV 202

  Fly   222 ILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETISAQAKATVSV-LLEPEAHARWNLREI 285
            ||:.::...:||||.::..|.:..|...|.....|..::     ||:.: :|:.:...|..:::|
Human   203 ILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV-----ATLLMHMLQVDPLKRATIKDI 262

  Fly   286 LNCAWLR 292
            ....|.:
Human   263 REHEWFK 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	85/264 (32%)
PRKAA2	NP_006243.2	STKc_AMPK_alpha	13..268	CDD:270981	85/264 (32%)
		UBA_AID_AAPK2	285..349	CDD:270587
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	291..376
		AMPKA2_C	395..550	CDD:213385
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..521