Protein Alignment Tssk and MARK3

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_001122390.2
• Gene: MARK3 / 4140
• HGNCID: 6897
• Length: 753
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 95/296 - (32%)
• Similarity: 153/296 - (51%)
• Gaps: 21/296 - (7%)

  Fly     6 SSAGIRQLGTRSSDVDALAQRG-YNVGHKIGEGSYATVITAGYADDHGHGVHLACKIIDKAKAPT 69
            |.:|.|...:.:|..|.....| |.:...||:|::|.|..|.:...   |..:|.|||||.:...
Human    33 SRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILT---GREVAIKIIDKTQLNP 94

  Fly    70 DFVNKFFPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIW 134
            ..:.|.| ||:.|:..::|.||:::..:::....:::.|.||..|::..::...|.:.||:::..
Human    95 TSLQKLF-REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSK 158

  Fly   135 FFQMSKALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREM----KSETYCGS 195
            |.|:..|::|.|...|.|||||.||:||...:|||:|||||:        .|.    |.:|:|||
Human   159 FRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS--------NEFTVGGKLDTFCGS 215

  Fly   196 AAYAAPEVVCGRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETI 260
            ..|||||:..|:.||....|.|||||||:.:::..:|||..||.:|    |.|....:.::...:
Human   216 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL----RERVLRGKYRIPFYM 276

  Fly   261 SAQAKATVSVLLEPEAHARWNLREILNCAWLRTVEE 296
            |...:..:...|......|..|.:|:...|:....|
Human   277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHE 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	88/268 (33%)
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		1/2 (50%)
		STKc_MARK	55..307	CDD:270974	87/267 (33%)
		UBA_MARK3_4	325..367	CDD:270590
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..600
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..655
		MARK1-3_C	654..751	CDD:213381