Protein Alignment Tssk and MARK1

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_001273053.1
• Gene: MARK1 / 4139
• HGNCID: 6896
• Length: 796
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 90/271 - (33%)
• Similarity: 147/271 - (54%)
• Gaps: 12/271 - (4%)

  Fly    28 YNVGHKIGEGSYATVITAGYADDHGHGVHLACKIIDKAKAPTDFVNKFFPRELEILTKIDHSNII 92
            |.:...||:|::|.|..|.:...   |..:|.|||||.:.....:.|.| ||:.|:..::|.||:
Human    60 YRLQKTIGKGNFAKVKLARHVLT---GREVAVKIIDKTQLNPTSLQKLF-REVRIMKILNHPNIV 120

  Fly    93 QIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIWFFQMSKALKYLHNLDIAHRDLKC 157
            ::..:::....:::.|.||..|::..::...|.:.||:::..|.|:..|::|.|...|.|||||.
Human   121 KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKA 185

  Fly   158 ENILLSKRLNIKLADFGFARYCRDDNGREMKSETYCGSAAYAAPEVVCGRPYDPKLADAWSLGVI 222
            ||:||...:|||:|||||:......|    |.:|:|||..|||||:..|:.||....|.||||||
Human   186 ENLLLDGDMNIKIADFGFSNEFTVGN----KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVI 246

  Fly   223 LFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETISAQAKATVSVLLEPEAHARWNLREILN 287
            |:.:::..:|||..||.:|    |.|....:.::...:|...:..:..||......|.:|.:|:.
Human   247 LYTLVSGSLPFDGQNLKEL----RERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMK 307

  Fly   288 CAWLRTVEESQ 298
            ..|:....|.:
Human   308 DRWMNVGHEEE 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	88/262 (34%)
MARK1	NP_001273053.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		STKc_MARK	59..311	CDD:270974	88/262 (34%)
		UBA_MARK1	331..371	CDD:270588
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..495
		MARK1-3_C	697..794	CDD:213381