DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14305 and TSSK2

DIOPT Version :9

Sequence 1:	NP_650732.1	Gene:	CG14305 / 42233	FlyBaseID:	FBgn0038630	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_443732.3	Gene:	TSSK2 / 23617	HGNCID:	11401	Length:	358	Species:	Homo sapiens

Alignment Length:	286	Identity:	131/286 - (45%)
Similarity:	185/286 - (64%)	Gaps:	13/286 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DVDALAQRGYNVGHKIGEGSYATVITAGYADDHGHGVHLACKIIDKAKAPTDFVNKFFPRELEIL 83
            |...|.::||.||..:|:||||.|.:| |::.....|  |.||||:.|.|||||.:|.|||::||
Human     3 DATVLRKKGYIVGINLGKGSYAKVKSA-YSERLKFNV--AVKIIDRKKTPTDFVERFLPREMDIL 64

  Fly    84 TKIDHSNIIQIHSILQRGP-KIFIFMRYAENGDLLSHIKRSGPIDEKQSKIWFFQMSKALKYLHN 147
            ..::|.:||:.:.|.:... :|:|.|.....||||..||..|.:.|..::..|.|:|.|:||.|:
Human    65 ATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHD 129

  Fly   148 LDIAHRDLKCENILLSKRLNIKLADFGFARYC-RDDNGREMKSETYCGSAAYAAPEVVCGRPYDP 211
            |||.||||||||:||.|..||||:||||::.| ||.|||.:.|:|:|||||||||||:...||.|
Human   130 LDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQP 194

  Fly   212 KLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETISAQAKATVSVLLEPEA 276
            |:.|.|||||||:||:...||:|||::.|:|..|:..:..|.|  .:.::.:.|..:..:|:|:.
Human   195 KVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPR--SKNLTCECKDLIYRMLQPDV 257

  Fly   277 HARWNLREILNCAWLRTVEESQTPIP 302
            ..|.::.|||:.:||      |.|.|
Human   258 SQRLHIDEILSHSWL------QPPKP 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14305	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	124/265 (47%)
CG14305	NP_650732.1	S_TKc	28..287	CDD:214567	122/260 (47%)
TSSK2	NP_443732.3	STKc_TSSK1_2-like	10..272	CDD:271067	124/266 (47%)
		S_TKc	12..272	CDD:214567	123/264 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BHY0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3315
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007569
OrthoInspector	1	1.000	-	-		otm42266
orthoMCL	1	0.900	-	-		OOG6_103794
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5387
SonicParanoid	1	1.000	-	-		X507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.890