Protein Alignment Tssk and Sik2

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_848825.2
• Gene: Sik2 / 235344
• MGIID: 2445031
• Length: 931
• Species: Mus musculus
• Alignment Length: 289
• Identity: 87/289 - (30%)
• Similarity: 153/289 - (52%)
• Gaps: 30/289 - (10%)

  Fly    25 QRG------YNVGHKIGEGSYATV------ITAGYADDHGHGVHLACKIIDKAKAPTDFVNKFFP 77
            |||      |::...:|:|::|.|      ||.         ..:|.|||||::.....:.|.:
Mouse    11 QRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITK---------TEVAIKIIDKSQLDAVNLEKIY- 65

  Fly    78 RELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIWFFQMSKAL 142
            ||::|:..:||.:||:::.:::....:::...||:||::..::...|.::|.:::..|:|:..|:
Mouse    66 REVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAV 130

  Fly   143 KYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETYCGSAAYAAPEVVCGR 207
            .|.|...:.|||||.||:||...:|||:|||||..:.:  .|..:  .|:|||..||||||..|:
Mouse   131 DYCHGRKVVHRDLKAENLLLDNNMNIKIADFGFGNFFK--TGELL--ATWCGSPPYAAPEVFEGQ 191

  Fly   208 PYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETISAQAKATVSVLL 272
            .|:....|.||:||:|::::...:|||...|..|    |.|....|.::...:|...:..:..:|
Mouse   192 QYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPIL----RQRVLEGRFRIPYFMSEDCEHLIRRML 252

  Fly   273 EPEAHARWNLREILNCAWLRTVEESQTPI 301
            ..:...|.::.:|....|:......|.||
Mouse   253 VLDPSKRLSIAQIKEHKWMLIEVPVQRPI 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	81/275 (29%)
Sik2	NP_848825.2	STKc_SIK	19..271	CDD:270973	80/269 (30%)
		UBA_SIK2	297..341	CDD:270592
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..586
		RK-rich region, required for cAMP responsiveness. /evidence=ECO:0000269|PubMed:29211348	595..624
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	631..662
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	798..842