Protein Alignment Tssk and Sik1

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_034961.2
• Gene: Sik1 / 17691
• MGIID: 104754
• Length: 779
• Species: Mus musculus
• Alignment Length: 295
• Identity: 91/295 - (30%)
• Similarity: 160/295 - (54%)
• Gaps: 22/295 - (7%)

  Fly     1 MSKYNSSAGIRQLGTRSSDVDALAQRGYNVGHKIGEGSYATVITAGYADDHGHGV---HLACKII 62
            ||::::...    ||.......|....|:|...:|:|::|.|..|      .|.|   .:|.|||
Mouse     4 MSEFSAVPS----GTGQGQQKPLRVGFYDVERTLGKGNFAVVKLA------RHRVTKTQVAIKII 58

  Fly    63 DKAKAPTDFVNKFFPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPID 127
            ||.:..:..:.|.: ||::::..::|.|||:::.:::....::|...:|:||::..::..:|.:.
Mouse    59 DKTRLDSSNLEKIY-REVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLS 122

  Fly   128 EKQSKIWFFQMSKALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETY 192
            |.:::..|:|:..|::|.||..|.|||||.||:||...::||||||||..:.:.  |..:  .|:
Mouse   123 ENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKP--GEPL--STW 183

  Fly   193 CGSAAYAAPEVVCGRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQ 257
            |||..||||||..|:.|:....|.|||||:|::::...:|||..||..|    |.|....|.::.
Mouse   184 CGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTL----RQRVLEGRFRIP 244

  Fly   258 ETISAQAKATVSVLLEPEAHARWNLREILNCAWLR 292
            ..:|...:..:..:|..:...|..:.:|....|::
Mouse   245 FFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQ 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	85/266 (32%)
Sik1	NP_034961.2	STKc_SIK	26..278	CDD:270973	85/266 (32%)
		UBA_SIK1	300..349	CDD:270591
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..375
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..472
		RK-rich region	586..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..641