Protein Alignment Tssk and aak-1

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_741254.3
• Gene: aak-1 / 176230
• WormBaseID: WBGene00019801
• Length: 589
• Species: Caenorhabditis elegans
• Alignment Length: 283
• Identity: 90/283 - (31%)
• Similarity: 146/283 - (51%)
• Gaps: 29/283 - (10%)

  Fly    22 ALAQRGY-NVGH-----KIGEGSYATV-----ITAGYADDHGHGVHLACKIIDKAKAP-TDFVNK 74
            |||..|: .:|:     .||:|::..|     |..||        .:|.||:::.:.. ...|||
 Worm    12 ALAGTGHLKIGNFVIKETIGKGAFGAVKRGTHIQTGY--------DVAIKILNRGRMKGLGTVNK 68

  Fly    75 FFPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIWFFQMS 139
             ...|::.|.|:.|.:|.::..::.....||:.|.....|:|.|:|.|.|.:..::|:.:|.|:.
 Worm    69 -TRNEIDNLQKLTHPHITRLFRVISTPSDIFLVMELVSGGELFSYITRKGALPIRESRRYFQQII 132

  Fly   140 KALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETYCGSAAYAAPEVV 204
            ..:.|.||..|.|||||.||:||....|||:||||.:.|..|.:    ...|.|||..|||||::
 Worm   133 SGVSYCHNHMIVHRDLKPENLLLDANKNIKIADFGLSNYMTDGD----LLSTACGSPNYAAPELI 193

  Fly   205 CGRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETISAQAKATVS 269
            ..:.|.....|.||.||||:.|:...:||||.|:..|....::.::.....:::    ||...:|
 Worm   194 SNKLYVGPEVDLWSCGVILYAMLCGTLPFDDQNVPTLFAKIKSGRYTVPYSMEK----QAADLIS 254

  Fly   270 VLLEPEAHARWNLREILNCAWLR 292
            .:|:.:...|.:::.|:|.:|.|
 Worm   255 TMLQVDPVKRADVKRIVNHSWFR 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	85/275 (31%)
aak-1	NP_741254.3	Protein Kinases, catalytic domain	21..276	CDD:473864	84/271 (31%)
		UBA_AID_AMPKalpha	292..356	CDD:270521
		AMPKA_C	390..>479	CDD:213378