Protein Alignment Tssk and SIK1

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_775490.2
• Gene: SIK1 / 150094
• HGNCID: 11142
• Length: 783
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 84/268 - (31%)
• Similarity: 153/268 - (57%)
• Gaps: 18/268 - (6%)

  Fly    28 YNVGHKIGEGSYATVITAGYADDHGHGV---HLACKIIDKAKAPTDFVNKFFPRELEILTKIDHS 89
            |::...:|:|::|.|..|      .|.|   .:|.|||||.:..:..:.|.: ||::::..::|.
Human    27 YDIERTLGKGNFAVVKLA------RHRVTKTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHP 84

  Fly    90 NIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIWFFQMSKALKYLHNLDIAHRD 154
            :||:::.:::....::|...:|:||::..::..:|.:.|.:::..|:|:..|::|.|:..|.|||
Human    85 HIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRD 149

  Fly   155 LKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETYCGSAAYAAPEVVCGRPYDPKLADAWSL 219
            ||.||:||...::||||||||..:.:  :|..:  .|:|||..||||||..|:.|:....|.|||
Human   150 LKTENLLLDGNMDIKLADFGFGNFYK--SGEPL--STWCGSPPYAAPEVFEGKEYEGPQLDIWSL 210

  Fly   220 GVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETISAQAKATVSVLLEPEAHARWNLRE 284
            ||:|::::...:|||..||..|    |.|....|.::...:|...::.:..:|..:...|..:.:
Human   211 GVVLYVLVCGSLPFDGPNLPTL----RQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQ 271

  Fly   285 ILNCAWLR 292
            |....|:|
Human   272 IRQHRWMR 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	82/265 (31%)
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	82/265 (31%)
		UBA_SIK1	300..349	CDD:270591
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..377
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..477
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348	583..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	619..643