Protein Alignment Tssk and Prkaa1

DIOPT Version :10

• Sequence 1: NP_650732.1
• Gene: Tssk / 42233
• FlyBaseID: FBgn0038630
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: XP_036014946.1
• Gene: Prkaa1 / 105787
• MGIID: 2145955
• Length: 589
• Species: Mus musculus
• Alignment Length: 339
• Identity: 93/339 - (27%)
• Similarity: 153/339 - (45%)
• Gaps: 76/339 - (22%)

  Fly    28 YNVGHKIGEGSYATVIT--AGYADDHGHG-----------VHLAC--------------KIIDKA 65
            |.:|..:|.|::..|..  .||.|....|           ||:.|              ||:::.
Mouse    27 YILGDTLGVGTFGKVKVPEKGYTDARLLGTLPQQQYLNSYVHIDCLVGKHELTGHKVAVKILNRQ 91

  Fly    66 KAPT-DFVNKFFPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEK 129
            |..: |.|.| ..||::.|....|.:||:::.::.....||:.|.|...|:|..:|.::|.:|||
Mouse    92 KIRSLDVVGK-IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEK 155

  Fly   130 QSKIWFFQMSKALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETYCG 194
            :|:..|.|:...:.|.|...:.|||||.||:||...:|.|:||||.:....|  |..::  |.||
Mouse   156 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD--GEFLR--TSCG 216

  Fly   195 SAAYAAPEVVCGRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKL------------------ 241
            |..||||||:.||.|.....|.||.||||:.::...:||||.::..|
Mouse   217 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 281

  Fly   242 ------------------LEDQRNRKFAFRRKLQETISAQAKATVSVLLEPEA------HARWNL 282
                              ::|.|..:: |::.|.:.:..:..:..|.:::.||      ....:.
Mouse   282 VISLLKHMLQVDPMKRAAIKDIREHEW-FKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSE 345

  Fly   283 REILNCAWLRTVEE 296
            .|:|:|.:.|..::
Mouse   346 EEVLSCLYNRNHQD 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tssk	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	92/332 (28%)
Prkaa1	XP_036014946.1	STKc_AMPK_alpha	24..309	CDD:270981	84/287 (29%)
		UBA_AID_AAPK1	326..390	CDD:270586	7/34 (21%)
		AMPKA1_C	434..587	CDD:213384