DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7694 and RNF165

DIOPT Version :9

Sequence 1:	NP_001138076.1	Gene:	CG7694 / 42230	FlyBaseID:	FBgn0038627	Length:	147	Species:	Drosophila melanogaster
Sequence 2:	NP_689683.2	Gene:	RNF165 / 494470	HGNCID:	31696	Length:	346	Species:	Homo sapiens

Alignment Length:	116	Identity:	38/116 - (32%)
Similarity:	54/116 - (46%)	Gaps:	18/116 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FEELGHEPTGPLGANDLARNLKRLQVLAIMNGIDMEIEVPEASKRAILELPVHEIVKSDEG---- 65
            :|||       |...|...|:.|   .|:.|.|: ....|...|:   ..|.....|.|||
Human   239 YEEL-------LQLEDRLGNVTR---GAVQNTIE-RFTFPHKYKK---RRPQDGKGKKDEGEESD 289

  Fly    66 GDLECSVCKEPAEEGQKYRILPCKHEFHEECILLWLKKTNSCPLCRYELET 116
            .|.:|::|....|:|:..|.|||.|.||:.|:..||..:..||:||.::||
Human   290 TDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICRVDIET 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7694	NP_001138076.1	zf-RING_2	69..111	CDD:290367	16/41 (39%)
RNF165	NP_689683.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..76
		Ubiquitin binding. /evidence=ECO:0000269\|PubMed:26656854, ECO:0007744\|PDB:5D0K	266..268		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..288		7/23 (30%)
		RING-H2_RNF111_like	292..337	CDD:319388	18/44 (41%)
		Ubiquitin binding. /evidence=ECO:0000269\|PubMed:26656854, ECO:0007744\|PDB:5D0K	309..313		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910