DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and ZBTB39

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_055645.1	Gene:	ZBTB39 / 9880	HGNCID:	29014	Length:	712	Species:	Homo sapiens

Alignment Length:	978	Identity:	173/978 - (17%)
Similarity:	266/978 - (27%)	Gaps:	401/978 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 MDQQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHP 171
            |..:..|:..|||.||...|......|.:||||:.....:..||:.:|:..:.||:.:||.....
Human     1 MGMRIKLQSTNHPNNLLKELNKCRLSETMCDVTIVVGSRSFPAHKAVLACAAGYFQNLFLNTGLD 65

  Fly   172 HPIIYLKD-VRYSEMRSLLDFMYKGE-----VNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSD 230
            ....|:.| :..:....:|.|:|..|     :|||     :..:.||.|   |:.|
Human    66 AARTYVVDFITPANFEKVLSFVYTSELFTDLINVG-----VIYEVAERL---GMED--------- 113

  Fly   231 CDKLRDSAASSPTGRGPSNYTGGLGGAGGVADAMRESRDSLRSRCERDLRDELTQRSSSSMSERS 295
                                                                |.|...|:..:..
Human   114 ----------------------------------------------------LLQACHSTFPDLE 126

  Fly   296 SAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGERSPSVGSASAAAAAAAVAAAVAAAANRSA 360
            |.|.|....:.:.:.:|          .|:.|
Human   127 STARAKPLTSTSESHSG----------TLSCP--------------------------------- 148

  Fly   361 SADGCSDRGSERGTLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNNNNNNNNNNNSSSNNNNSSS 425
            ||:.....|..||            ..||...|.|....|..||
Human   149 SAEPAHPLGELRG------------GGDYLGADRNYVLPSDAGG--------------------- 180

  Fly   426 NRERNNSGERERERERERERDRDRELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQDRHYPQDS 490
                                               |.|...||.:|:.::||       |.||
Human   181 -----------------------------------SYKEEEKNVASDANHSL-------HLPQ-- 201

  Fly   491 QANFKSSPVPKTGGSTSESEDAGGRHDSPL------SMTTSVHLGGGGGNV-------------- 535
                ...|.|||       ||    ||:|.      ||.|...||.....:
Human   202 ----PPPPPPKT-------ED----HDTPAPFTSIPSMMTQPLLGTVSTGIQTSTSSCQPYKVQS 251

  Fly   536 -------------GAASALSGLSQSLSIKQELMDAQQQQQHREHHVALPPDYLPSAALKLHAEDM 587
                         .|....:|.:..||..:...|....|........|..|.|   ..:..|||:
Human   252 NGDFSKNSFLTPDNAVDITTGTNSCLSNSEHSKDPGFGQMDELQLEDLGDDDL---QFEDPAEDI 313

  Fly   588 STLLTQHALQAADARDEHNDAKQLQLDQTDNIDGR-VKCFNIKHDRHPDRELDRNH-REHDDDPG 650
            .|  |:..::.:|..::     :|...:.||.:.: :.|...|....|:.:|.|.| |:|.|...
Human   314 GT--TEEVIELSDDSED-----ELAFGENDNRENKAMPCQVCKKVLEPNIQLIRQHARDHVDLLT 371

  Fly   651 VIEEVVVDHVREMEAGNEH------------DPEEMK-----EAAYHATPPKYRRAVVYAPPHPD 698
            ...:|...|.::..:...|            |..|.|     :...|.....:...::.   ||:
Human   372 GNCKVCETHFQDRNSRVTHVLSHIGIFLFSCDMCETKFFTQWQLTLHRRDGIFENNIIV---HPN 433

  Fly   699 EE------------------AASGS--GSDIYVDGGYNCEY------KCKELNMRAIR-CSRQQH 736
            :.                  ||.|.  ..|.:|..|:..::      .|...:.|.:. ||...|
Human   434 DPLPGKLGLFSGAASPELKCAACGKVLAKDFHVVRGHILDHLNLKGQACSVCDQRHLNLCSLMWH 498

  Fly   737 MMSH--------------------YSPHHPHHRSLIDC-----------PAEAAYSPPVANNQAY 770
            .:||                    ...|...|:||.|.           .:||||...|:.::
Human   499 TLSHLGISVFSCSVCANSFVDWHLLEKHMAVHQSLEDALFHCRLCSQSFKSEAAYRYHVSQHK-- 561

  Fly   771 LASNGAVQQLDLSTYHGHANHQLHQHPPSATHPSHSQSSPHYPSASGAGAGAGSVSVSIAGSASG 835
             .::|    ||.....|      .|||        :......|:....|
Human   562 -CNSG----LDARPGFG------LQHP--------ALQKRKLPAEEFLG---------------- 591

  Fly   836 SATSAPASVATSAVSPQPSSSSTGSTSSAAAVAAAAAAAANRRDHNIDYSTLFVQLSGTLPTLYR 900
                     ...|:..||.:|...........|..:....:||.|           :|..|  |:
Human   592 ---------EELALQGQPGNSKYSCKVCGKRFAHTSEFNYHRRIH-----------TGEKP--YQ 634

  Fly   901 CVSCNKIVSNRWH---HANIHR-PQSHECPVCGQKFTRRDNMKAHCKIKHADIKDRF-----FSH 956
            |..|:|....|..   |...|. ...:.|.|||...:..:.|..|..:....:...|     |.:
Human   635 CKVCHKFFRGRSTIKCHLKTHSGALMYRCTVCGHYSSTLNLMSKHVGVHKGSLPPDFTIEQTFMY 699

  Fly   957 YVH 959
            .:|
Human   700 IIH 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	26/100 (26%)
		BTB	137..221	CDD:197585	23/89 (26%)
		C2H2 Zn finger	901..918	CDD:275368	5/19 (26%)
		C2H2 Zn finger	925..944	CDD:275368	6/18 (33%)
ZBTB39	NP_055645.1	BTB	20..119	CDD:306997	29/167 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..162		10/87 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..224		22/127 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..260		0/23 (0%)
		C2H2 Zn finger	453..474	CDD:275368	6/20 (30%)
		C2H2 Zn finger	482..502	CDD:275368	5/19 (26%)
		C2H2 Zn finger	510..530	CDD:275368	1/19 (5%)
		C2H2 Zn finger	540..560	CDD:275368	5/19 (26%)
		C2H2 Zn finger	607..627	CDD:275368	3/19 (16%)
		zf-H2C2_2	619..643	CDD:316026	9/36 (25%)
		C2H2 Zn finger	635..655	CDD:275368	5/19 (26%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7558
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950