DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and BTBD18

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001138573.1	Gene:	BTBD18 / 643376	HGNCID:	37214	Length:	712	Species:	Homo sapiens

Alignment Length:	871	Identity:	167/871 - (19%)
Similarity:	259/871 - (29%)	Gaps:	339/871 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 QREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHP----HPIIYLKDVRYSEMRSLLDF 191
            |.:..|||.|..|||.|.||..|||||||:| |..|:.:.|    ..::.|..::.|.:|.|:||
Human    29 QSDVFCDVLLQAEGEAVPAHCCILSACSPFF-TERLERERPAQGGKVVLELGGLKISTLRKLVDF 92

  Fly   192 MYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSDCDKLR---DSAASSPTGRGPSNYTGG 253
            :|..|:.|.|......|..|..|:|            |:.:.|:   .....:|.||
Human    93 LYTSEMEVSQEEAQDVLSAARQLRV------------SELESLQLEGGKLVKAPQGR-------- 137

  Fly   254 LGGAGGVADAMRESRDSLRSRCERDLRDELTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAA 318
                       |.:|:.|:.                                         .:||
Human   138 -----------RLNRECLQP-----------------------------------------TSAA 150

  Fly   319 AVALGLTTPTGGERSPSVGSASAAAAAAAVAAAVAAAANRSASADGCSDRGSERGTLERTDSRDD 383
            .::..:.||:....:|...:.:.....|....::                |.|.|..|
Human   151 PISARVVTPSHHPHTPLPTNQTPCPLGAIRLKSL----------------GKEEGPQE------- 192

  Fly   384 LLQLDYSNKDNNNSNSSSTGGNNNNNNNNNNNSSS-----NNNNSSSNRERNNSGERERERERER 443
                                   ||..|.:|.|.:     ......:.:|:|:|.....:..||.
Human   193 -----------------------NNRQNADNLSGTLLLKRKARACPTPQEKNSSPSSHSQEPREN 234

  Fly   444 ERDR----------------DRELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQ---------- 482
            :.|.                |:.|....: :||.||......:|...:.||.|..
Human   235 KNDTALDPTVLSPPSLYPSVDKHLLPRKI-RLSRSKPSPGICTSKPSSILSGSSSVPATPGRRLW 298

  Fly   483 -----DRHYPQDSQANFKSSPVP---------KTGGS----------TSESEDAG--GR------ 515
                 ::..|:|.....::||:.         |||||          .|:|.:.|  ||
Human   299 RQRSVNKETPEDKPKPGRASPLQSTPNPSGLGKTGGSRKRSPEVRAPNSDSAEEGQVGRVKLRKI 363

  Fly   516 ---------HDSPLSMT-TSVHLGGGGGNVGAASAL--------------SGLSQSLSIKQELMD 556
                     .::||..| .|..:...||:....|..              :.|.|...:..:|.|
Human   364 VNGTCWEVVQETPLKNTQDSPQIPDPGGDFQEPSGTQPFSSNEQEMSPTRTELCQDSPMCTKLQD 428

  Fly   557 AQQQQQHREHHVALPPDYLPSAALKLHAEDM------------STLLTQ------HALQAADARD 603
            ......|...|..:..::..|..| :..|.|            :.||.|      :.:.:|.|..
Human   429 ILVSASHSPDHPVVKSEFESSPEL-VEKEPMLAIDCREPYAFDTALLEQPCEAEEYRITSAAATS 492

  Fly   604 EHNDAKQLQLDQTDN-----------------------------IDGRVKCFNIKHDRHPDREL- 638
            |..:.....|..:|.                             |:|...|.       ||.||
Human   493 ELEEILDFMLCGSDIEPPIGSLESPGAEGCRTPTYHLTETGKNWIEGEEWCL-------PDMELW 550

  Fly   639 DRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEEMKEAAYHATPPKYRRAV-VYAPPHPDEEAA 702
            .|...|.:.:|               ||....|.|:....  ..|.:....: |.....||.|..
Human   551 PRELTELEKEP---------------AGENRGPTELLSPL--VMPSEVSEVLSVGGRWTPDLEIT 598

  Fly   703 SGSGSDIYVDGGYNCEYKCKELNMRAIRCSRQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVANN 767
            |...    :||                    |:..:.|.|......||..|      .|||.:|
Human   599 SSQP----LDG--------------------QEDKLLHVSSLDTPQRSYGD------LSPPCSN- 632

  Fly   768 QAYLASNGAVQQLDLSTYHGHANHQLHQHPPSATHPS-HSQSSPHYPSASGAGAGAGSVSVSIAG 831
               ....|.  ::.|:|     :..|:..|.:....| ||:.....|::|    ....:.| :..
Human   633 ---WVETGL--EVSLTT-----DELLYPSPKAGKEVSGHSELLGSLPASS----EEEEIDV-VDW 682

  Fly   832 SASGSATSAPASVATSAVSPQPSSSS 857
            :|.|..  .|.:|  .:|.|.|||.|
Human   683 TAEGRL--VPTTV--PSVWPDPSSES 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	36/93 (39%)
		BTB	137..221	CDD:197585	34/87 (39%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
BTBD18	NP_001138573.1	BTB	24..120	CDD:306997	37/103 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..176		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..355		28/143 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..410		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..676		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..712		7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910