DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fru and mod(mdg4)

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_788698.1	Gene:	mod(mdg4) / 49228	FlyBaseID:	FBgn0002781	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	694	Identity:	149/694 - (21%)
Similarity:	248/694 - (35%)	Gaps:	223/694 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 AMDQQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQ-NQ 169
            |.|:||.|.|||..|||:......|.|..|.||:||.||:.||||:.:||.|||:|..:|.| ..
  Fly     2 ADDEQFSLCWNNFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPS 66

  Fly   170 HPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSDCDKL 234
            :.|.|::|.:|.:|.::.|:.|||.|||||.|.:||.|:.||||||::|||||
  Fly    67 NTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESLQIKGLTDN------------ 119

  Fly   235 RDSAASSPTGRGP------------------------------SNYTGGLGG------------- 256
             |.|...|....|                              .....|||.
  Fly   120 -DPAPQPPQESSPPPAAPHVQQQQIPAQRVQRQQPRASARYKIETVDDGLGDEKQSTTQIVIQTT 183

  Fly   257 AGGVADAMRESRDSLRSRCERDLRDELTQRSSSS----------MSERSSAAAAAAAAAAAVAAA 311
            |...|..:::.:.   .:..:.::.:..|..:::          .::|||...|:::|....:..
  Fly   184 AAPQATIVQQQQP---QQAAQQIQSQQLQTGTTTTATLVSTNKRSAQRSSLTPASSSAGVKRSKT 245

  Fly   312 GGNVNAAAVALGLTTPTGGERSPSVGSASAAAAAAAVAAAVAAAANRS----------------- 359
            ..:.|... .|..||.||...:..:.........:.|:||.|....:|
  Fly   246 STSANVMD-PLDSTTETGATTTAQLVPQQITVQTSVVSAAEAKLHQQSPQQVRQEEAEYIDLPME 309

  Fly   360 ----ASADGCSDRGSERGTLERTDSRDDL---LQLDYS----NKDNNNSNSSSTGG--------- 404
                :..|...|.|...|..|.|...||.   ::.|.|    |:|..|..:::|.|
  Fly   310 LPTKSEPDYSEDHGDAAGDAEGTYVEDDTYGDMRYDDSYFTENEDAGNQTAANTSGGGVTATTSK 374

  Fly   405 ------NNNNNNNNNNNSSSNNNNSSSNRERNNSGERERERERERERDRDRELSTTP--VEQLSS 461
                  :.|.:.::..::|.:..|:.:....:.|..:...|:|.|.:.:..:.:..|  :|:|.:
  Fly   375 AVVKQQSQNYSESSFVDTSGDQGNTEAQAATSASATKIPPRKRGRPKTKVEDQTPKPKLLEKLQA 439

  Fly   462 SKRRRKNSSSNCDNSLSSSHQDRHYPQDSQANFKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSV 526
            :....:.|.                             |....||::    ||     :.:..:.
  Fly   440 ATLNEEASE-----------------------------PAVYASTTK----GG-----VKLIFNG 466

  Fly   527 HLGGGGGNVGAASALSGLSQSLSIKQ-------------ELMDAQQQQQHREHHV---------A 569
            ||          ...|......|:.|             .:.|.::...:...||         .
  Fly   467 HL----------FKFSFRKADYSVFQCCYREHGEECKVRVVCDQKRVFPYEGEHVHFMQASDKSC 521

  Fly   570 LPPDYLPSAALKLHAEDMS-TLLTQHALQAADARD-EHNDAKQLQLDQTDNIDGRVKCFNIKHDR 632
            ||..::|..:..:.:...| .||.::..:..:|.| |..|.::.::.:.|.|
  Fly   522 LPSQFMPGESGVISSLSPSKELLMKNTTKLEEADDKEDEDFEEFEIQEIDEI------------- 573

  Fly   633 HPDRELDRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEEMKE 676
                |||    |.:..|...|||              ||.:.:|
  Fly   574 ----ELD----EPEKTPAKEEEV--------------DPNDFRE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	47/95 (49%)
		BTB	137..221	CDD:197585	44/84 (52%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
mod(mdg4)	NP_788698.1	BTB	22..118	CDD:279045	47/95 (49%)
		BTB	33..118	CDD:197585	44/84 (52%)
		FLYWCH	452..512	CDD:282369	11/78 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010