DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and ttk

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	894	Identity:	217/894 - (24%)
Similarity:	331/894 - (37%)	Gaps:	286/894 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 QQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHP 173
            |:||||||||.:||..|...||..|...|||||.||:.:|||:.:||||||||.|:|:.:...||
  Fly     6 QRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHP 70

  Fly   174 IIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSDCDKLRDSA 238
            |:.||||.||:|:|||||||:|||:|.|..|..||:.||||:::|||:.|:       ||...:|
  Fly    71 IVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVND-------DKPSPAA 128

  Fly   239 ASSPTGRGPSNYTGGLGGAGGVADAMRESRDSLRSRCERDLRDELTQRSSSSMSERSSAAAAAAA 303
            |::           |.|..|..:.|.......::...       :.||:      ||.|....|:
  Fly   129 AAA-----------GAGATGSESTATTPQLQRIQPYL-------VPQRN------RSQAGGLLAS 169

  Fly   304 AAAAVAAAGGNVNAAAVALGLTTPTGGERSPSVGSASAAAAAAAVAAAVAAAANRSASADGCSDR 368
            ||.|     ||           |||...: ||:       .::|:.........|..|
  Fly   170 AANA-----GN-----------TPTLPVQ-PSL-------LSSALMPKRKRGRPRKLS------- 203

  Fly   369 GSERGTLERTDSRDDLLQLDYSNKDNNN-SNSSSTGGN----NNNNNNNNNNSSSNNNNSSSNRE 428
            ||..||..           ||.:.|..| .|.||..||    |.:.:.|::.|..|..|:....:
  Fly   204 GSSNGTGN-----------DYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTDD 257

  Fly   429 RNNSGERERERERERERDRDRELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQDRHYPQDSQAN 493
            .|.|              ||           |...:|.|||.   |:.:.|.|:|
  Fly   258 LNES--------------RD-----------SLPSKRSKNSK---DHRVVSHHED---------- 284

  Fly   494 FKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSVHLGGGGGNVGAASALSGLSQSLSIKQELMDAQ 558
             .|:.|..|..:...|:...|...:.:|.|..     ||.:.|.:..:|.|        |:.|.:
  Fly   285 -NSTSVTPTKATPELSQRLFGSSSTTISATAP-----GGSSTGPSETISLL--------EISDER 335

  Fly   559 QQQQHREHHVALPPDYLPS-AALKLHAEDMSTLLTQHALQAADARDEHNDAKQLQLDQTDNIDGR 622
            :.          .|.:||: ..||:.|.:.:|    .|.|.:......:..|..|...::|.:..
  Fly   336 ES----------APVHLPTILGLKIRAINTTT----PAQQGSPQTPTKSKPKIRQATGSNNSNSL 386

  Fly   623 VKCFNIKHDRHPDRELDRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEEMKEAAYHATPPKYR 687
            :|                                     :...|...|||         .||..|
  Fly   387 LK-------------------------------------QQLRGGAKDPE---------VPPATR 405

  Fly   688 RAVVYAPPHPDEEAASGSGSDIYVDGGYNCEYKCKE------------LNMRAIRCSRQQHMMSH 740
            ......|                 :...|.|.:.||            :.:.::..:.:|.....
  Fly   406 ITGAVTP-----------------NAALNAEEQSKEMPKKNQDEVNACIGLHSLANAAEQQAAQV 453

  Fly   741 YSPHHPHHRSLIDCPAEAAYSPPVANNQAYLASNGAVQQLDLSTYHGHANHQLHQHPPSA----- 800
            .|..:.||:.|:                 ::|:|.::  |:.:.|:   ..|..:.|.||
  Fly   454 ASTGNLHHQLLL-----------------HMAANNSM--LNTTDYY---QQQQQESPSSAGQFMD 496

  Fly   801 --------THPSHSQSSPHYPSASGAGAGAGSVSVSIAGSASGSATSAPAS----VATSAVSPQP 853
                    .........|.:...:.|...||     :.|.....|.:.||.    .|.:|.:|.|
  Fly   497 DDLELLSLNDQQDKSDEPDHEMVTLADENAG-----LPGYQGNEAEATPAQEDSPAAETATAPPP 556

  Fly   854 SSSSTGSTSSAAAV------AAAAAAAANRRDHNIDYSTLFVQL---SGTLPTLYRCVSC----- 904
            :..| |...:...:      ..|.:...::.:|..:.|...:.|   :..:..:|||..|
  Fly   557 APRS-GKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGVYRCTECAKENM 620

  Fly   905 NKIVSNRW---HHANIHRPQSHE----CPVCGQKFTRRDNMKAHCKIKH 946
            .|...|::   .||.::....|.    ||||.::|:|.|.||.|.|:.|
  Fly   621 QKTFKNKYSFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKMKNHLKMTH 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	54/94 (57%)
		BTB	137..221	CDD:197585	51/83 (61%)
		C2H2 Zn finger	901..918	CDD:275368	6/24 (25%)
		C2H2 Zn finger	925..944	CDD:275368	10/18 (56%)
ttk	NP_001189329.1	BTB	23..119	CDD:279045	55/95 (58%)
		BTB	34..119	CDD:197585	52/84 (62%)
		C2H2 Zn finger	612..638	CDD:275370	6/25 (24%)
		zf-C2H2_4	646..669	CDD:290605	11/22 (50%)
		C2H2 Zn finger	648..669	CDD:275370	11/20 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020