DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and br

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	972	Identity:	236/972 - (24%)
Similarity:	353/972 - (36%)	Gaps:	319/972 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 MD--QQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQ 169
            ||  |.|||||||:.:::|....:|...||..||||||||.::|||:.:||||||||..:.....
  Fly     1 MDDTQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTP 65

  Fly   170 HPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSDCDKL 234
            ..||:|.|:||.:.::.:|::|:|.|||||.|.||..||||||.|:|.|||.....:..|...::
  Fly    66 CKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQI 130

  Fly   235 RDSAASSPTGRGPSN---------YTGGLGGAGGVADAMRESRD-----------SLRSRCERDL 279
            ::.|.|.  ||.|.|         :.|.|...||.:...  ||.           ||.|.    :
  Fly   131 QNLANSG--GRTPLNTHTQSLPHPHHGSLHDDGGSSTLF--SRQGAGSPPPTAVPSLPSH----I 187

  Fly   280 RDELTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGERSPSVGSASAAAA 344
            .::|.:|  .:|..||||||||...:.|.....|:.|:..:: |.........||.:....|
  Fly   188 NNQLLKR--MAMMHRSSAAAAAEETSHAFKRLRGSDNSLPLS-GAVGSGSNNNSPDLPPLHA--- 246

  Fly   345 AAAVAAAVAAAANRSASADGCSDRGSERGTLERTDSRDDLLQLDYSN-KDNNNSN---------S 399
                         ||||.             ::|.:       |:|. |.:||:|         :
  Fly   247 -------------RSASP-------------QQTPA-------DFSTIKHHNNNNTPPLKEEKRN 278

  Fly   400 SSTGGNNNNNNNNNNNSSSN------------------------------------NNNSSSNRE 428
            ..||..|:.|.|.|.|.:||                                    |||:::|.|
  Fly   279 GPTGNGNSGNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANANDE 343

  Fly   429 RNNSGERERERERERERDRDR-ELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQDRHY---PQD 489
            .:|....|.:..|....|..: .||:...|::.              :.|:|.|....:   |.:
  Fly   344 HSNDSTGEHDANRSSSGDGGKGSLSSGNDEEIG--------------DGLASHHAAPQFIMSPAE 394

  Fly   490 SQA------NFKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSVHL------GGGGGNVGAASALS 542
            ::.      ||.:.......|..::.:.:|....||...:|...|      ||.||....:|:.:
  Fly   395 NKMFHAAAFNFPNIDPSALLGLNTQLQQSGDLAVSPQGGSTGSLLSGVIVPGGSGGTPSNSSSNN 459

  Fly   543 GLSQSLSIKQELMDAQQQQQH----REHHVALPPDYLPSAALKLHAEDMSTLLTQHALQAADARD 603
            ..:.|.:.:|::  .||...|    ::||                    ||
  Fly   460 NNNNSNNQQQKV--EQQSSPHQLLQQQHH--------------------ST-------------- 488

  Fly   604 EHNDAKQLQLDQTDNIDGRVKCFNIKHDRHPDRELDRNHREHDDDPG---VIEEVVVDHVREMEA 665
            .|.::.||:.:|..:..|..|..::......:|.|.|:.:...|..|   ........|.||.|.
  Fly   489 PHTNSPQLKQEQPKSGGGSCKSSDLHIAAGSERSLSRSSQGMPDAGGHSATPSPTAAYHKRERER 553

  Fly   666 GNEHDPE---EMKEAAYH----------ATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDGGYNC 717
            ..|.:.|   |.:.:..|          .:||         ||.|...:..|
  Fly   554 ERERERERERERERSLDHERDLERPGGTGSPP---------PPPPSHHSHFG------------- 596

  Fly   718 EYKCKELNMRAIRCSRQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVANNQAYLASNGAVQQLDL 782
                             ||.:|....||..|.:..:..|.||:.   |:..|:.|
  Fly   597 -----------------QHPLSLLPSHHQLHATHHELSAAAAHH---AHAHAHAA---------- 631

  Fly   783 STYHGHA---------NHQLHQHPPSATHPSHSQSSPHYPSASGAGAGAGSVSVSIAGSASGSAT 838
               |.||         :|.|..|..::..||.:.||.  ..|.|.|.|||.     .|...||..
  Fly   632 ---HAHALARAGSPMEHHHLLHHRRASLSPSGAVSSA--SGAGGRGGGAGG-----PGGPGGSLL 686

  Fly   839 SAPASVATSAVSPQPSSSSTGSTSSAAAVAAAAAAAANRRDHNIDYSTLFVQLSGTLPTLYRCVS 903
            |                          :|.|...|.|||         |.:.|  .|...:||..
  Fly   687 S--------------------------SVRAQDVAQANR---------LLLPL--PLNACHRCDV 714

  Fly   904 CNKIVSNRWHHANIHRPQSH-------ECPVCGQKFTRRDNMKAHCKIKHADIKDR--FFSH 956
            |.|::|.:. ....|:.|.|       .|.:|.:.|...:::..|..|.|...|:.  :|.|
  Fly   715 CGKLLSTKL-TLKRHKEQQHLQPLNNAVCNLCHKVFRTLNSLNNHKSIYHRRQKNHHSYFHH 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	49/94 (52%)
		BTB	137..221	CDD:197585	46/83 (55%)
		C2H2 Zn finger	901..918	CDD:275368	4/16 (25%)
		C2H2 Zn finger	925..944	CDD:275368	4/18 (22%)
br	NP_001162638.2	BTB	22..118	CDD:279045	50/95 (53%)
		BTB	33..118	CDD:197585	47/84 (56%)
		C2H2 Zn finger	712..729	CDD:275368	4/17 (24%)
		C2H2 Zn finger	742..763	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020