DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and CG6118

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001097806.1	Gene:	CG6118 / 41884	FlyBaseID:	FBgn0038339	Length:	967	Species:	Drosophila melanogaster

Alignment Length:	717	Identity:	186/717 - (25%)
Similarity:	262/717 - (36%)	Gaps:	171/717 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 HGHAHSHYAALDLQTPHKRNIETDVRAPPPPLPP-----------------PPLPLPPASPSLQI 97
            |..||.|       .||         .|.|..||                 ..|......||.:.
  Fly   332 HQLAHPH-------QPH---------TPRPSTPPTTAQQIHITATQHQAAQQQLHQQQQQPSHKQ 380

  Fly    98 SRYNTDQGAMDQQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFE 162
            .:...|...:| |:.|.|||...|:.....||.:.|.:.|||:|..|:..|||:.:||.|||||:
  Fly   381 QQSYADPNTID-QYLLSWNNFHGNMCRGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQ 444

  Fly   163 TIFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNY 227
            .|||:|...|||:.:.||..|.|..||||||.|:|||....||:|||.||:::::||....||:
  Fly   445 QIFLENPSSHPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEAMKIKGLHTEKNLD- 508

  Fly   228 RSDCDKLRDSAASSPT------GRGPSNYTGG-LGGAGGVADAMRES-RDSLR--SRCERDLRDE 282
             ||...:.....|..|      |....|.|.| ..|.||...:.:.| ..||.  :||.
  Fly   509 -SDASDISSPHESDGTECRYERGTHSVNITSGHAAGYGGAPSSQQSSPSPSLNGPNRCP------ 566

  Fly   283 LTQRSSSSMSERSSAAAAAAAAAAAVAAA---------GGNVNAAAVALGLTTPTGGERSPSVGS 338
             |..||......:.|.......:.|..|.         ..|.|::.....|....|........|
  Fly   567 -TPLSSGGSGNPNYAGFREHIKSKATLAETFMKNLNRNNNNNNSSNNYNHLGGSNGSLNLTEADS 630

  Fly   339 ASAAAAAAAVAAAVAAA-------ANRSASADGCSDRGSER--GTLER-----TDSRDDLLQLDY 389
            .|.|...|.....:.:|       |.|.......::.|.|:  ..:||     .:..||.|..::
  Fly   631 NSFAILQANSKKMLDSARKQHKYLAKRKILMHYNTELGGEKRLKEMERDRYPSAEQHDDALNNNH 695

  Fly   390 SNKDNN-----------NSNSSSTGGNN-----------NNNNNNNNNSSSNNNNSSSNRERNNS 432
            |:..:|           .:...||..||           .||:|||.|.|||||||||:.:.|:.
  Fly   696 SHAQDNIMEPIITTIVPQTPPPSTHNNNFKIRLVESHHLTNNSNNNQNQSSNNNNSSSSPQSNDC 760

  Fly   433 GERERE----RERERERDRDRELS---TTPVEQLSSSKRRRKNSSSNCDN-SLSSSHQDRHYPQD 489
            ...|..    :.......|:||.:   .||...:...||..|...|..:| |.::.|.|    :.
  Fly   761 NNDEEALNLVQIPNANGSRNREATPTCATPTPDIQLIKREVKTELSPAENLSNNNGHDD----EM 821

  Fly   490 SQANFKSSPVPKTGGSTSESE-DAGGRHDSPLSMTTSVHLGGGGGNVGAASALSGLSQSLSIKQE 553
            :.|.|..........|..:.| |:...:..|          ||..|.|.|.||.        |.:
  Fly   822 AGAGFDRKYDDNNNNSGLDMETDSNNNNSKP----------GGDNNNGLALALG--------KHK 868

  Fly   554 LMDAQQQQQHREHHVALPPDYLPSAALKLHAEDMSTLLTQHALQAADARDEHNDAKQLQLDQTDN 618
            |:.|..:...::|     ||:                             ||.|.:..:.|...|
  Fly   869 LLSAINRNIEQDH-----PDH-----------------------------EHQDQQDREADHGGN 899

  Fly   619 IDGRVKCFNIKHDRHPDRELDRNHREHDDDPGVIEEV--VVDHVREMEAGNEHDPE------EMK 675
            ........|..|.:|.|....:|....:...|:..:|  :.:..||.|...|.:.|      |:|
  Fly   900 NCNSDDNNNNNHSQHLDLSTIKNIATAEILCGLKSKVLKLEEEQREREREREREREACRSLSEIK 964

  Fly   676 EA 677
            .|
  Fly   965 NA 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	48/94 (51%)
		BTB	137..221	CDD:197585	45/83 (54%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
CG6118	NP_001097806.1	Myb_DNA-bind_4	20..97	CDD:290549
		BTB	408..508	CDD:279045	49/99 (49%)
		BTB	419..510	CDD:197585	47/92 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451887
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7558
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900