DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and BtbVII

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	1008	Identity:	230/1008 - (22%)
Similarity:	345/1008 - (34%)	Gaps:	357/1008 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 QQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHP 173
            ||||||||||..|...|.:|||....|.|||||.||..::||:.:|||||.||:.:|..|...||
  Fly     4 QQFCLRWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQHP 68

  Fly   174 IIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGL----TDNNNLNYRSDCDKL 234
            |:.||||:|.::::::||||.|||||.|..||..|||||.|:::||    ||..||. :||....
  Fly    69 IVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGLAEMPTDPANLT-KSDSKSS 132

  Fly   235 RDS---AASSPTGRGPSNYTGGLGGAGG--VADAMRESRDSLRSRCER---------------DL 279
            .|.   ...:..|.|..|..|.||...|  |.|::..|.::.:.:.::               ..
  Fly   133 TDGTEMVGGAGVGTGAGNSAGSLGAGSGSSVGDSLWSSSEAQQFQQQQQQQAQQQAQQQHHHHQQ 197

  Fly   280 RDELTQRSSSSM-------------SERSSAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGE 331
            :.:|.|:...:.             .::.|..|.||.                     |......
  Fly   198 QQQLQQQQQQAQQQQQQQQHHHHHHQQQQSGQAQAAQ---------------------THHHQMR 241

  Fly   332 RSPSVGSASAAAAAAAVAAAVAAAANRSASADGCSDRGSERGTLERTDSRDDLLQLDYSNKDNNN 396
            |:||..||..:.|                         :.|..|.:
  Fly   242 RTPSPLSAGTSPA-------------------------TRRKRLRK------------------- 262

  Fly   397 SNSSSTGGNNNNNNNNNNNSSSNNNNSSSNRERNNSGERERERERERERDRDRELSTTPVEQ--- 458
              ||:.|..:.||....:|||.:..:.:     .|:|                 ||...:.|
  Fly   263 --SSNNGSGDRNNAEEQHNSSLDAGSGA-----GNAG-----------------LSLAQMNQMTF 303

  Fly   459 ----------LSSSKRRRKNSSSNC-----DNSLSSSHQDRHYPQDSQANF----KSSPVPKTGG 504
                      |.::|..::::|:..     |:.|...|...|.....:.:.    ::.|:..:||
  Fly   304 GAGGGLAGHSLHAAKLLKESASAELEQQPQDSDLDDGHGHLHMQIKPEVDIGGVNQTMPLDISGG 368

  Fly   505 STSESEDAGGRHDS---------------PLSMTTSVHLGGGG-------GNVG----------A 537
            :|....||.....|               ||...:|...|.|.       |.||          :
  Fly   369 TTPSEHDAPNSQSSHSEPSPAHAPHPPHPPLGAASSSSGGSGSFERSFSIGGVGSVECDPDGTPS 433

  Fly   538 ASALSG------LSQSLSIKQELMDAQQQQQHREHHVALPPDYLP---SAALKLHAEDMSTLLTQ 593
            :.|:.|      |::...:|::........|......|...|:.|   :.|....|.|.||..:.
  Fly   434 SPAVMGTKRNRVLTRQPRVKRDSDSISSTNQISPDTAATTLDFDPFNAAGATSATARDYSTTGSH 498

  Fly   594 HALQAADARDEHNDAKQLQLDQTDNIDGRVKCFNIKHDRH----PDRELDRNHREHDDDPGVIEE 654
            |.        .|..|                   :.|..|    |.| ::|    |..:|.....
  Fly   499 HL--------HHQSA-------------------VHHHHHLLTVPPR-IER----HASEPAPSLA 531

  Fly   655 VVVDHVREMEAGNEHDPEEMKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDGGYN--- 716
            ....|:..:.:..   |..:|:   |:.|...|::.::.       |.|||||...:..|.|
  Fly   532 PSTPHLLSVPSST---PYLIKQ---HSDPLLPRQSALHM-------AGSGSGSSSAMATGSNPFA 583

  Fly   717 ---CEYKCKELNMRAIRCSRQQHMMSHYSP---HHPHHRSLIDCPAEAAY---SPPVANNQAYL- 771
               .:|........|          |:.:|   |||||.||    .|:.|   |||.|.:..||
  Fly   584 PLHRQYSHPLSGSNA----------SYVTPAPLHHPHHISL----PESIYASGSPPPAGSSQYLV 634

  Fly   772 --------------------ASNGAVQQLD-----LSTYHGHANHQLHQHPPSATHP-----SHS 806
                                ||.|:...:.     :::.:....:...:||.|.|..     :|.
  Fly   635 PTRVVACPVVSSETAATPTNASPGSSSTVSAAVSVVTSPNAGLQNSASRHPLSPTFSIGSDVAHE 699

  Fly   807 QSSPHYPSASGAGAGAGSVSVSIAGSASGSATSAPASVATSAVSPQPSSSSTGSTSSAAAVAAAA 871
            :.|||.||.|      .|..|..||       ..||..|....|...:|.|...:.:...:....
  Fly   700 RRSPHSPSIS------RSQVVERAG-------KNPAEAANGGGSRLRTSKSASGSITGTHLHPGQ 751

  Fly   872 AAAANRRDHNIDYSTLFVQLSGTLPT-------LYRCVSC----NKIVSNRWHHANIHRPQSHEC 925
            |..::..:|              |||       |.|.||.    .:|::       :..|:|..|
  Fly   752 ATMSSSFEH--------------LPTLRVKNEELQRSVSSPQTQREIIT-------LENPRSSHC 795

  Fly   926 PV-----------C-----GQKFTRRDNMKAHC 942
            ||           |     |.....|...|.||
  Fly   796 PVIRPGPALGCNFCWNTIDGHGRILRRKTKYHC 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	50/98 (51%)
		BTB	137..221	CDD:197585	46/87 (53%)
		C2H2 Zn finger	901..918	CDD:275368	3/20 (15%)
		C2H2 Zn finger	925..944	CDD:275368	9/34 (26%)
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	49/92 (53%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	46/84 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020