DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and bab1

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_728565.1	Gene:	bab1 / 38116	FlyBaseID:	FBgn0004870	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	1103	Identity:	244/1103 - (22%)
Similarity:	351/1103 - (31%)	Gaps:	448/1103 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RESPLGVGHPHGHGHLHSHAHAHGHGHAHSHYAALDLQTPHKRNIETDVRAPPPPLPPPPLPLPP 90
            |.||.| |..........||.|.|.|.:       .:.:|..|:...
  Fly    54 RTSPTG-GAKDEDKESQGHAVAGGGGSS-------PVSSPQGRSSSV------------------ 92

  Fly    91 ASPSLQISRYNTDQGAMDQQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILS 155
            ||||           :..|||||||||:.||||.:...|||.|...||||||:|.::|||:.:||
  Fly    93 ASPS-----------SSSQQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLS 146

  Fly   156 ACSPYFETIFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLT 220
            ||||||:|:..:....|||:.::||.:|:::::::|||:||:||.|..:...|:.||.|:||||.
  Fly   147 ACSPYFQTLLAETPCQHPIVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGLA 211

  Fly   221 DNNNLNYRSDCDKLRDSAASSPTGRGPSNYTGGLGGAGGVADAMRESRDSLRSRCERDLRDELTQ 285
            |..::      :....:||::.:.|.||              :.:||..:  ||.|.|...|..:
  Fly   212 DVTHM------EAATAAAAAASSERMPS--------------SPKESTST--SRTEHDREREAEE 254

  Fly   286 RSSSSMSER----SSAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGERSPSVGSASAAAAAA 346
            ..:....|:    |....|....:......|.||..             .|.||..:.....|..
  Fly   255 LLAFMQPEKKLRTSDWDPAELRLSPLERQQGRNVRK-------------RRWPSADTIFNPPAPP 306

  Fly   347 AVAAAVAAAANRSASADGCSDRGSERGTLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNNNNNNN 411
            :..:::.||               ||..||
  Fly   307 SPLSSLIAA---------------ERMELE----------------------------------- 321

  Fly   412 NNNNSSSNNNNSSSNRERNNSGERERERERERERDRDRELSTTPVEQLSSS------KRRRKNSS 470
                                        ::||||.||..|.|.|.:...||      .||.:.:.
  Fly   322 ----------------------------QKERERQRDCSLMTPPPKPPMSSGSTVGATRRLETAI 358

  Fly   471 SNCD--------NSLS-SSHQDRHYPQDSQA--------------NFKSSPVP---KTGGSTSES 509
            ...|        ..|| ||......||..||              :..:||.|   :|.||....
  Fly   359 HALDMPSPAATPGPLSRSSRPHSQSPQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTAGSAHHP 423

  Fly   510 EDAGGRHDSPLSMTTSV-------------------------HLGG---GGGNVGAASA------ 540
            ....|....||....::                         |.||   |||.||...|
  Fly   424 ASPAGDSRFPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGVGGGGAGGVGSG 488

  Fly   541 -LSGLSQSLSIKQELMDAQQQQQHREHHVALPPDYLPSAALKLHAEDMSTLL-TQHALQAADARD 603
             .|.|:..|.||                        |..|..:..|:.:.:: ..||...|....
  Fly   489 GGSSLADDLEIK------------------------PGIAEMIREEERAKMMENSHAWMGATGST 529

  Fly   604 EHNDAKQLQLDQTDNIDGRVKCFN-----IKHDRHPDR-----------------------ELDR 640
            ...|:.|.||.....     ||:|     :.|.|..:|                       .|.:
  Fly   530 LAADSYQYQLQSMWQ-----KCWNTNQNLMHHMRFRERGPLKSWRPETMAEAIFSVLKEGLSLSQ 589

  Fly   641 NHREHD--------------------------------------------DD--PGVIEEVVVDH 659
            ..|::|                                            |:  .|||:.||.
  Fly   590 AARKYDIPYPTFVLYANRVHNMLGPSIDGGPDLRPKGRGRPQRILLGIWPDEHIKGVIKTVVF-- 652

  Fly   660 VREMEAGNEHDPEEMKEAAYHATPPKYRRAVVYAPPHPDEE------AASG------------SG 706
                     .|.:::|:.:..|..|.|.|   ::|..|.::      .|||            :|
  Fly   653 ---------RDTKDIKDESLAAHMPPYGR---HSPAFPLQDLPLSYPGASGALAGAPSSMACPNG 705

  Fly   707 SDIYVDGGYNCEYKCKELNMRAIRC----SRQQHMMSHYSP---HHPHH---------------- 748
            |......|...|....:....|:..    .|||..|:...|   :.|.|
  Fly   706 SGPQTGVGVAGEQHMSQETAAAVAAVAHNIRQQMQMAAVPPGLFNLPPHPGVGGGVGNVPGAAGG 770

  Fly   749 RSLIDCPAEAAYSPP-----------------------VANNQAYLASNGAVQQLDLSTYHGHAN 790
            |:.|. ||.::.|.|                       :.:.|...|::..:|||.|.....|.:
  Fly   771 RASIS-PALSSGSGPRHAPSPCGPAGLLPNLPPSMAVALHHQQQQQAAHHHMQQLHLQQQQAHLH 834

  Fly   791 HQLHQHPPSATHPSHSQSSPHYPSASGAGAGAGSVSVSIAGSASG-----SATSAPASVATSAV- 849
            |  ||.........|.|........||.||.:.|   |.:.|:.|     .|.|:|....|..:
  Fly   835 H--HQQQQQQQQQQHHQGGHQVAHKSGFGASSSS---SASSSSMGQHHAPKAKSSPLRSETPRLH 894

  Fly   850 SP---------------QPS-------------SSSTGSTSSAAAVA-----AAAAAAANRRD 879
            ||               .||             |.|:.|:|:|||.|     |.||:||...|
  Fly   895 SPLGDLGLDMASYKREFSPSRLFAEDLAELVGASVSSSSSSAAAATAPPERSAGAASAATGAD 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	45/94 (48%)
		BTB	137..221	CDD:197585	41/83 (49%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
bab1	NP_728565.1	BTB	117..216	CDD:279045	46/98 (47%)
		BTB	128..213	CDD:197585	41/84 (49%)
		HTH_psq	569..614	CDD:283007	3/44 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447067
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940