DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and psq

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001369078.1	Gene:	psq / 36118	FlyBaseID:	FBgn0263102	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	895	Identity:	165/895 - (18%)
Similarity:	309/895 - (34%)	Gaps:	264/895 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 QQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHP 173
            |.|.|||||:...:|.|...|.:..:..||||:||..::|||:.:|||||.||:.:.|:|...||
  Fly     8 QYFSLRWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHP 72

  Fly   174 IIYL-KDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSDCDKLRDS 237
            .|.| .|:.::::::::||:|:||::|.:|.|...|:|||.|:::||.:.     ..:.|.|.|:
  Fly    73 TIILPADIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAEQLKIKGLCET-----AENADDLNDA 132

  Fly   238 AASSPTGRGPSNYTGGLGG--------AGGVADAMRESRDSLRSRCERDLRDE------------ 282
            |.::.|  ...|....:.|        .|..:.::.:.:...:.:.::..:::
  Fly   133 ATATIT--VSENIQQAVVGNIVNAAIVPGAPSPSLEQQQQHHQQQQQQQAQEQHQQQQVHAQQQQ 195

  Fly   283 ----------LTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAAAVALGL-TTPTGG----ER 332
                      |||...||.|...|....:::|:.:..:..|...|:....|| .||...    .:
  Fly   196 QQQQQINAALLTQHGVSSGSVSLSGQLLSSSASGSSGSLAGGQQASQTPSGLQPTPRKSRLKRSK 260

  Fly   333 SPSVGSASAAAAAAAVAAAVAAAANRSASADGCSDRGSE-------RGTLERTDSRDDLLQLDYS 390
            ||.:.|...|.::             ..|:.|.:.:..:       :..|.:..:.:.::.|..:
  Fly   261 SPDLSSGGGAGSS-------------GGSSSGSTQQQPQPAHHHHPQTILIQGQNPNSIVSLQQT 312

  Fly   391 NKDNNNSNSSSTGGNNNNNNNNNNNSSSNNNNSSSNRERNNSGERERERERERERDRDRELSTTP 455
            ...|....|.|...::..::.:.:|....:.:........:|.|...:.|.|.:.::..:...:.
  Fly   313 ADGNYIPVSGSGDDSDAEDHEHEHNHGHGHGHGGHTHGHGHSHEHSHDHEHEHKPNKICKTEHSV 377

  Fly   456 VEQLSSSKRRRKNSSSNCDNSLSSSHQDRHYPQDSQANFKSSPVPKTGGSTSESEDAGGRHDSPL 520
            ....|       ||||..:|:...|    ......||......|.:.|..|..
  Fly   378 ASPAS-------NSSSASNNAAGVS----GVTSTGQAIVTQIVVARDGKDTKN------------ 419

  Fly   521 SMTTSVHLGGGGGNVGAASALSGLSQSLSIKQELMDAQQQQQHREHHVALPPDYLPSAALKLHAE 585
              .||:.:|..||.:|             :....:|...:          ||  .|||.
  Fly   420 --MTSLGMGMNGGLLG-------------VPMGFLDFTPE----------PP--APSAT------ 451

  Fly   586 DMSTLLTQH----ALQAADARDEHNDAKQLQLDQTDNIDGRVKCFNIKHDRHPDRELDRNHREHD 646
              ...:|:|    ...:.|.||..|..:.|.:|  :::..::.    :.|:.|...:..:|...:
  Fly   452 --PVTVTEHVDLSCNPSTDTRDLSNTTEPLDID--NHLAQQIH----RLDQSPMHSISHHHTGDE 508

  Fly   647 DDPGVIEEVVVDHVREMEAGNEHD--PEEMKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDI 709
            .:..:::.:..:.:.......:|.  .:..::.|:|....::::       |..:
  Fly   509 SNSNLVQHIKSEVIEAKHLAAQHHALSQAQQQHAHHQAHQQHQQ-------HQQQ---------- 556

  Fly   710 YVDGGYNCEYKCKELNMRA------IRCSRQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVANNQ 768
                    :::.::.::.|      .:..:||........||...:......|.||
  Fly   557 --------QHQQQQQHLHAQQLLAQSQLQQQQQQQQQQQQHHQQQQQQAAAAAAAA--------- 604

  Fly   769 AYLASNGAVQQLDLSTYHG-HANHQLH----------------QHPPS----------------- 799
                           ..|| |..|..|                :|.|.
  Fly   605 ---------------GVHGQHGGHVTHADIGGATVMEIDPSQIKHEPGMIITPEIVNMMSSGHMD 654

  Fly   800 -------------ATHPSHSQSSPHY---------------PSASGAGAGAGSVSVSIAGSASGS 836
                         |....|.|..|||               |...|||.|         |..||.
  Fly   655 MYNSDTSEDSMMIANGSPHDQKEPHYTNLDQQHGLGGSVCGPGPGGAGGG---------GGMSGG 710

  Fly   837 ATSAPASVATSAVSPQPSSSSTGSTSSAAAVAAAAAAAANRRDHNIDYST 886
            |.|.....|..|:..|     ..|.:.|:|:....:....:|.|.:...|
  Fly   711 AGSGSGEKALDALKNQ-----NMSLTKASAIYGIPSTTLWQRAHRMGIET 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	39/95 (41%)
		BTB	137..221	CDD:197585	38/84 (45%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
psq	NP_001369078.1	BTB_POZ_BAB-like	34..118	CDD:349624	36/83 (43%)
		HTH_psq	717..>747	CDD:283007	6/34 (18%)
		HTH_psq	767..804	CDD:283007
		HTH_psq	821..866	CDD:283007
		HTH_psq	873..916	CDD:283007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020