DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and chinmo

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001188680.1	Gene:	chinmo / 33343	FlyBaseID:	FBgn0086758	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	895	Identity:	208/895 - (23%)
Similarity:	323/895 - (36%)	Gaps:	255/895 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 MD--QQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQN- 168
            ||  |||||:||:..:||....::|.:.:.|.||.|:|:|...|||:.||:|||..|..:| :|
  Fly     1 MDPQQQFCLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLF-ENT 64

  Fly   169 -QHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGL-TDNNNLNYRSDC 231
             .:...:|.|:......|.:||:|||||||:|.|.:|..|||:||||||:|| |:...|..:...
  Fly    65 PTNGQCVIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQ 129

  Fly   232 DKLRD-SAASSPTGRGPSNYTGGLGGAGGVADAMRESRDSLRSRCERDLRDELTQRSSSSMSERS 295
            ..:.| |...|||||                               |.:|:.|:..|||.:....
  Fly   130 QHMGDLSPLDSPTGR-------------------------------RSVRNSLSGGSSSIVPGGV 163

  Fly   296 SAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGERSPSVGSASAAAAAAAVAAAVAAAAN--- 357
            .......|..|...:..|..|..::| |:.  .||      |.|:||.|||:..:.:||:||
  Fly   164 GIGLGGGATGANSMSGMGIGNGLSLA-GMA--AGG------GMAAAANAAASSLSTLAASANIVD 219

  Fly   358 RSASADGCSDRGSERGTLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNNNNNNNNNNNSSSNNNN 422
            |..||......||..|           :...:|....|.|.:...|||...:...||...|..:.
  Fly   220 RCGSAGANIISGSAAG-----------IGGSHSGGAGNGSGTVGIGGNGVGSGGGNNGPISLGSG 273

  Fly   423 SSSNRERNNS-GERERE-------------------------RERERERDRDRELSTTPV--EQL 459
            :.:......| |..::|                         |....|..|.|.:..:|.  ::.
  Fly   274 AGAAHHLGGSTGILKQECDSLMHPGGSSSSSGMGYTHVPPIYRPINYEPPRKRAIVRSPYSEQEQ 338

  Fly   460 SSSKRRRKNSSSNCDNSLSSSHQDRHYPQDSQANFKSSPVPKTGGSTSESEDA---GGRHDSPLS 521
            ..|..|..:.||.|.:.::.  ...|.|..|    .||..| |...|..||.|   ..|:::...
  Fly   339 RGSVLRDGSKSSECPSPINK--PPYHRPSSS----ASSTAP-TEADTMHSERASPQSSRYENHSP 396

  Fly   522 MTTSVHLGGGGGNVGAASALSGL----------SQSLSIKQELMDAQQQQQHREHHVAL------ 570
            .||:       ||..|.|:|..:          :::....:||||........:..|.|
  Fly   397 STTA-------GNGNATSSLERIVKSERNNGSANEANDDDRELMDESTDNGAEDLRVKLENLKYS 454

  Fly   571 ---PPD-----YLPSAALK-LHAEDMSTLLTQHALQAADARDEHNDAKQLQLDQTDNIDG-RVKC 625
               ||:     ..|:..|: |.|:...:.....::..||..:..|..|....:..:..|| ::||
  Fly   455 PPPPPNSNTSSTTPNTLLENLKADGTLSSNLAASIAPADMLNVWNATKMNNKNSVNTADGKKLKC 519

  Fly   626 F----------NIK---HDRHP---------DRELDRNH-------REHDDDPGVIEEVVVDHVR 661
            .          |::   ..||.         :|...||:       |||..:.|
  Fly   520 LYCDRLYGYETNLRAHIRQRHQGIRVPCPFCERTFTRNNTVRRHIAREHKQEIG----------- 573

  Fly   662 EMEAGNEHDPEEMKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDGGYNC--EYKCKEL 724
             :.||....|..:..||..:.     .|...|..|.. |||:.:.:.:.::.....  :.|.|.|
  Fly   574 -LAAGATIAPAHLAAAAAASA-----AATAAASNHSPXEAAATAAASVVMNANKEAAKQRKRKTL 632

  Fly   725 NMRAIRCSRQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVANNQAYLASNGAVQQLDLSTYHGHA 789
            .|...:|.:::..|                         ||........:||    :.....|.|
  Fly   633 KMALEKCMQRRDAM-------------------------VAETTTGAGGDGA----EAGGESGEA 668

  Fly   790 NHQLHQHPPSATHPSHSQSSPHYPSASGAGA--GAGSVSVS-------------------IAGSA 833
                                     ..|||:  ||||....                   .|..|
  Fly   669 -------------------------VDGAGSEEGAGSEGTEPLTYEQQQQRMHQELTQQIRAAMA 708

  Fly   834 SGSATSAPASVATSAVSPQPSSSSTGSTSSAAAVAAAAAAAANRRDHNID 883
            :..|..|..|...:.|:...::::|.:|:.|.:...:.|.|::..|..::
  Fly   709 AEQAAEAMDSTMNTTVNTTTTTTTTTNTTGATSDGCSDAEASDGSDRPME 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	44/97 (45%)
		BTB	137..221	CDD:197585	42/86 (49%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
chinmo	NP_001188680.1	BTB	22..116	CDD:279045	42/94 (45%)
		BTB	33..116	CDD:197585	40/83 (48%)
		C2H2 Zn finger	519..540	CDD:275368	2/20 (10%)
		C2H2 Zn finger	547..568	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020