DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and Zbtb39

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_932152.1	Gene:	Zbtb39 / 320080	MGIID:	2443316	Length:	712	Species:	Mus musculus

Alignment Length:	965	Identity:	171/965 - (17%)
Similarity:	263/965 - (27%)	Gaps:	375/965 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 MDQQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHP 171
            |..:..|:.:|||.||...|......|.:||||:.....:..||:.:|:..:.||:.:||.....
Mouse     1 MGMRIKLQSSNHPNNLLKELNKCRLSETMCDVTIVVGSRSFPAHKAVLACAAGYFQNLFLNTGLD 65

  Fly   172 HPIIYLKD-VRYSEMRSLLDFMYKGE-----VNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSD 230
            ....|:.| :..:....:|.|:|..|     :|||     :..:.||.|
Mouse    66 AARTYVVDFITPANFEKILSFVYTSELFTDLINVG-----VIYEVAERL---------------- 109

  Fly   231 CDKLRDSAASSPTGRGPSNYTGGLGGAGGVADAMRESRDSLRSRCERDLRDELTQRSSSSMSERS 295
                                        |:.|.:|        .|.....|
Mouse   110 ----------------------------GMEDLLR--------ACHSTFPD-------------- 124

  Fly   296 SAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGE----RSPSVGSASAAAAAAAVAAAVAAAA 356
                               :.:.|:|..||:.:..:    ..|||
Mouse   125 -------------------LESTAIAKSLTSTSDSQCVTLSCPSV-------------------- 150

  Fly   357 NRSASADGCSDRGSERGTLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNNNNNNNNNNNSSSNNN 421
                  |.....|..||:.|            :...|.|....:..||
Mouse   151 ------DPTHPLGESRGSGE------------HFGPDRNYVLPTDAGG----------------- 180

  Fly   422 NSSSNRERNNSGERERERE------RERERDRDRELSTTPVEQLSSSKRRRKNSSSNCDNSLSSS 480
             |....||:.||:......      ..:..|.|..:..|.|..:::........|:....|.||.
Mouse   181 -SYKEEERSVSGDTNHGLPLPQLPLPPKSEDHDTPVPFTSVPSVATPPPVLGMVSTGIQTSTSSC 244

  Fly   481 HQDRHYPQDSQANFKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSVHLGGGGGNVGAASALSGLS 545
            .     |...|:|          |..|:|.....  |:.:.:||..:           |.||...
Mouse   245 Q-----PYKVQSN----------GDFSKSTFFAS--DNAVDITTQTN-----------SCLSNSD 281

  Fly   546 QSLSIKQELMDAQQQQQHREHHVALPPDYLPSAALKLHAEDMSTLLTQHALQAADARDEHNDAKQ 610
            .|.......||..|.....:..:.....          |||:.|  .:..::.:|  |..:|
Mouse   282 HSRDPSFGQMDELQLDDVGDEDLQFEDP----------AEDIGT--AEEVIELSD--DSEDD--- 329

  Fly   611 LQLDQTDNIDGR-VKCFNIKHDRHPDRELDRNH-REHDDDPGVIEEVVVDHVREMEAGNEH---- 669
            |....:||.:.: :.|...|....|:.:|.|.| |:|.|......:|...|.::..:...|
Mouse   330 LAFGDSDNRENKAMPCQVCKKVLEPNIQLIRQHARDHVDLLTGNCKVCETHFQDRNSRVTHVLSH 394

  Fly   670 --------DPEEMK-----EAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDGGYNCEYKC 721
                    |..|.|     :...|.....:...|:.   ||.|..:...|   ...|..:.|.||
Mouse   395 IGIFLFSCDMCETKFFTQWQLTLHRRDGIFDNNVIV---HPSEPLSGKLG---LFPGAASPELKC 453

  Fly   722 ----------------------------------KELNMRAIRCSRQQHMMSH------------ 740
                                              :.||:    ||...||:||
Mouse   454 AVCGKALAKDFHVVRCHILEHVNLKGQACSICDQRHLNL----CSLMWHMLSHLGISVFSCSVCA 514

  Fly   741 --------YSPHHPHHRSLID-------CP----AEAAYSPPVANNQAYLASNGAVQQLDLSTYH 786
                    ...|...|:.|.|       |.    :||||                       .||
Mouse   515 SSFVDWHLLEKHMVVHQGLEDVLFRCHLCSQSFRSEAAY-----------------------RYH 556

  Fly   787 GHANHQLHQHPPSATHPSHSQSSPHYPSASGAGAGAGSVSVSIAGSASGSATSAPASVATS---A 848
                  :.||..|              |...|....|...:::      .....||....|   |
Mouse   557 ------VSQHKCS--------------SGLDARPALGLPHLAL------QKRKLPAEEFLSEELA 595

  Fly   849 VSPQPSSSSTGSTSSAAAVAAAAAAAANRRDHNIDYSTLFVQLSGTLPTLYRCVSCNKIVSNRWH 913
            :..||.:|...........|..:....:||.|           :|..|  |:|..|:|....|..
Mouse   596 LQGQPGNSKYSCKVCGKRFAHTSEFNYHRRIH-----------TGEKP--YQCKVCHKFFRGRST 647

  Fly   914 ---HANIHR-PQSHECPVCGQKFTRRDNMKAHCKIKHADIKDRF-----FSHYVH 959
               |...|. ...:.|.|||...:..:.|..|..:....:...|     |.:.:|
Mouse   648 IKCHLKTHSGALMYRCTVCGHYSSTLNLMSKHVGVHKGSLPPDFTIEQTFMYIIH 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	25/100 (25%)
		BTB	137..221	CDD:197585	22/89 (25%)
		C2H2 Zn finger	901..918	CDD:275368	5/19 (26%)
		C2H2 Zn finger	925..944	CDD:275368	6/18 (33%)
Zbtb39	NP_932152.1	BTB	20..119	CDD:279045	28/155 (18%)
		BTB	31..120	CDD:197585	26/145 (18%)
		C2H2 Zn finger	345..366	CDD:275368	7/20 (35%)
		C2H2 Zn finger	374..394	CDD:275368	3/19 (16%)
		C2H2 Zn finger	402..420	CDD:275368	4/17 (24%)
		C2H2 Zn finger	453..474	CDD:275368	1/20 (5%)
		C2H2 Zn finger	482..502	CDD:275368	6/23 (26%)
		C2H2 Zn finger	510..530	CDD:275368	1/19 (5%)
		C2H2 Zn finger	540..560	CDD:275368	7/48 (15%)
		C2H2 Zn finger	607..627	CDD:275368	3/19 (16%)
		zf-H2C2_2	619..642	CDD:290200	9/35 (26%)
		C2H2 Zn finger	635..655	CDD:275368	5/19 (26%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7558
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950