DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and btbd18

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	XP_017951392.1	Gene:	btbd18 / 100498010	-ID:	-	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	713	Identity:	135/713 - (18%)
Similarity:	220/713 - (30%)	Gaps:	237/713 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 WNNHPTNLTGVLTSLLQREA----LCDVTL-ACEGETVKAHQTILSACSPYFETIF--------- 165
            ||   ..|...:...|||:.    .||||| ..|||.|..|..:|:|||||...:.
Frog    10 WN---PRLLRTMFLQLQRQQNTGFFCDVTLQGGEGEGVSVHACLLAACSPYLAKLLASVTEVSQL 71

  Fly   166 -----LQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQV---RGL-TD 221
                 :|......|:.:..:....:..|:.:||..|:.|...::...|:.|..||:   .|| .:
Frog    72 DTDSAIQTDCTGHILTVPGIPSCYLLPLVHYMYTSELEVTPENVHGVLEAARRLQIPELEGLRLE 136

  Fly   222 NNNL-------NYRSDCDKLRDSAASSPTGRGPSNYT-GGLGGAGGVADAMRESRDSLRSRCERD 278
            ...|       ....||.....|..::.:|.|...:| ..:.....|...|.|....:
Frog   137 GGRLVRPELARKLNRDCFGSVISQYATESGNGKQIFTKEEITSGRNVPVRMHEQGPCI------- 194

  Fly   279 LRDELTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGERS-PSVGSASAA 342
                |.:|::...:..:...:.......|.::..||:....:.: ...||  |:| ||.......
Frog   195 ----LEKRTNKEHTFPADTGSLLRGKMEASSSLQGNIENPLLEI-TKNPT--EKSGPSTVQTCFQ 252

  Fly   343 AAAAAVAAAVAAAANRSASADG--------------------------CSDRGSERGTLERTDSR 381
            :......|...:...::.||..                          .|:.|::.....:||.:
Frog   253 SRENYECAFQDSGTTQNVSAINQDIEMTKLSSEIPLIVLNPDQKRHILVSEHGADTVPSRKTDMQ 317

  Fly   382 D-DLLQLDYSNKDNNNSNSSSTGGNNN---------------------NNNNNNNNSSSNNNNSS 424
            | .|.:|..:.|....:...:|.|..|                     :.|..||.....|:|.:
Frog   318 DKKLFKLQRAYKVRKETGEQATKGKTNIIPLSRIIKLDRGEKQDMPQMDENIKNNFKHKQNHNMN 382

  Fly   425 SNRERNNSGERERERERERERDRDRELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQDRHYPQD 489
            ||..                            .|.|..|:..:|.:|.|...|
Frog   383 SNLN----------------------------PQDSVLKQVCRNKNSQCTIKL------------ 407

  Fly   490 SQANFKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSVHLGGGGGNVGAASALSGLSQSLSIKQEL 554
                              |..|.        |:.|..|:                        ::
Frog   408 ------------------ELNDP--------SIQTQSHI------------------------QV 422

  Fly   555 MDAQQQ--QQHREHHVALPPDYLPSAALKLHAEDMSTLLTQHALQAADARDEHN-----DAKQLQ 612
            ...||:  |.|.|.:.||..|...:..:   |:.|:..|.||..... .:.:|.     :.|::.
Frog   423 CPEQQRIVQSHLEENAALQKDVCVTCVI---AKPMANTLLQHKTVKV-VKLQHTGSNVMNTKKIL 483

  Fly   613 LDQTDNIDGRVK--CFNIKHDRHPDRELDRNHREHDDDPGVIEEVVVDH------VREME----- 664
            |::.|.|....|  |..||.|...| |.:..|:|      :::....::      :.|:|
Frog   484 LEERDMIISSQKRTCQGIKRDWCAD-EFEDKHKE------LVKRSKTENGHWWEEINEVESPAYA 541

  Fly   665 -AGNEHD-----PEEMKEAAYHATPPKYRRAVV---------YAPPHPDEEAASGSGSDIYVD 712
             :.||.|     |||:.|.....:.|......|         |....||    |.|.||..:|
Frog   542 LSPNEQDMQLNQPEELVEQILSVSSPSSSEVDVGGQSPVPTKYVGVRPD----SSSESDTEID 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	32/117 (27%)
		BTB	137..221	CDD:197585	28/102 (27%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
btbd18	XP_017951392.1	BTB_POZ_BTBD18	17..148	CDD:349602	33/130 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910