DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fru and Btbd18

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	XP_002729248.1	Gene:	Btbd18 / 100363270	RGDID:	2323370	Length:	724	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	144/759 - (18%)
Similarity:	224/759 - (29%)	Gaps:	266/759 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 QREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHP----HPIIYLKDVRYSEMRSLLDF 191
            |....||..|..|||.|.||..|||||||:| |..|:.:.|    ..::.|..::...:|.|:||
  Rat    29 QSGVFCDALLQAEGEAVPAHCCILSACSPFF-TERLERERPVQGRKVVLELGGLKIQTLRKLVDF 92

  Fly   192 MYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNNLNYRSDCDKLR---DSAASSPTGRGPSNYTGG 253
            :|..|:.|.|......|..|..|:|            |:.:.|:   .....:|.||
  Rat    93 LYTSEMEVSQEEAQDVLSAARQLRV------------SELETLQLEGGKLVKAPQGR-------- 137

  Fly   254 LGGAGGVADAMRESRDSLRSRCERDLRDELTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAA 318
                       |.:|:.|:                         ..:||..:|.|..........
  Rat   138 -----------RLNRECLQ-------------------------PPSAAPISARVVVPRSRPRTP 166

  Fly   319 AVALGLTTPTGGERSPSVGSASAAAAAAAVAAAVAAAANRSASADGCSDRGSERGTLERTDSRDD 383
            .......:|.|..:..|:|....|                           .::..|...|:..|
  Rat   167 LPVTQTPSPLGAVKLKSLGEEEGA---------------------------HKKSNLPNADNLSD 204

  Fly   384 LLQLDYS-----NKDNNNSNSSSTGGNNNNNNNNNNNS--------------------------- 416
            .|.|...     .::.::|.||...|...|.:|..:.:
  Rat   205 TLLLKKKARVCLTQERSSSPSSQREGPKENKSNPGSTALPSLYPSVDEQLLPRKIRLSRSKPSPH 269

  Fly   417 ------SSNNNNSSSN---------RERNNSGERERERERERERDRDRELST---TP----VEQL 459
                  ||..:..||.         |:|..|     |..:..::.:..|:||   ||    |.:.
  Rat   270 VYTSKPSSMLSGPSSMPTAPGRRLWRQRTVS-----EATQGVDKQKPGEVSTLQSTPDPPDVGKT 329

  Fly   460 SSSKRRRKNSSSNCDNSLSSSHQDR--------------------HYPQDSQANFKSSPVPKTGG 504
            ...|:....|.:...||:......|                    ...|||....:||...:..|
  Rat   330 GGKKQPSPESRAPASNSVEEGQVGRVKLRKIVNGTCWEVVQEPPIRNTQDSPQILESSDADEPPG 394

  Fly   505 ---STSESEDAGGR----HDSP---------LSMTTSVHLGGGGGNVGAASALSGLSQSLSIKQE 553
               |:...::...|    ||||         ||.:.|..........|::..|:|....|:|...
  Rat   395 TLLSSVNEQEIPARIQLCHDSPENSRLQDILLSASHSPDHPVVKSEFGSSPMLTGKEPELNIDCR 459

  Fly   554 ---------LMDAQQQQQHREHHVALPPDYLPSAALKLHAEDMSTLL--------TQHALQAADA 601
                     |....:.:|:|          :.|||.....|::...:        ...:|::..|
  Rat   460 EPYTFDTTLLSQPCEAEQYR----------ITSAAATSELEEILDFMLCGSDVEPPVGSLESPGA 514

  Fly   602 RDEHNDAKQLQLDQTDNIDGRVKCFNIKHDRHPDRELDRNHREHDDDPGVIEEVVVDHVREMEAG 666
            ......:..|.....:.|:|...|.       ||.||...     |..|:.:|.|.::...:|
  Rat   515 EGCRTPSYHLSETGKNWIEGEEWCL-------PDMELWPR-----DLTGLEKEPVGENKEPVE-- 565

  Fly   667 NEHDPEEMKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGS---DIYV------DGGYNCEYKCK 722
             ...|..|:.....:..|   .:.:..|.....|..|..||   |:.:      ||
  Rat   566 -PFSPLVMRSENTESIEP---LSPLVMPSEVSREELSLRGSWTPDLEITSSQPLDG--------- 617

  Fly   723 ELNMRAIRCSRQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVAN 766
                       |...:.|.....|..||..|      .|||..|
  Rat   618 -----------QGEKLIHLDSSDPSQRSYSD------LSPPCPN 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	34/93 (37%)
		BTB	137..221	CDD:197585	32/87 (37%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
Btbd18	XP_002729248.1	BTB	24..123	CDD:279045	35/106 (33%)
Btbd18	XP_002729248.1	BTB	35..123	CDD:197585	33/100 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10373
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910