DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fru and Btbd18

DIOPT Version :9

Sequence 1:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster
Sequence 2:	NP_001138572.1	Gene:	Btbd18 / 100270744	MGIID:	3650217	Length:	723	Species:	Mus musculus

Alignment Length:	723	Identity:	147/723 - (20%)
Similarity:	227/723 - (31%)	Gaps:	253/723 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 QREALCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHP----HPIIYLKDVRYSEMRSLLDF 191
            |....||..|..|||.|.||..|||||||:| |..|:.:.|    ..::.:..::...:|.|:||
Mouse    29 QSGVFCDALLQAEGEAVPAHCCILSACSPFF-TERLERERPVQGRKVVLEMGGLKIQTLRKLVDF 92

  Fly   192 MYKGEVNVGQSSLPMFLKTA--------ESLQVRG-----LTDNNNLNYRSDCDKLRDSAASSPT 243
            :|..|:.|.|......|..|        |:||:.|     ......||  .:|  |:..||:..:
Mouse    93 LYTSEMEVSQEEAQDVLSAARQLRVSELETLQLEGGKLVKAPQGRRLN--REC--LQPPAAAPIS 153

  Fly   244 GR--GPSN------------------YTGGLGGAGGV--------ADAMRESRDSLRSR-CERDL 279
            .|  ||.:                  ....||...|.        ||::.:::...::| |
Mouse   154 ARVVGPKSRPQTPLPVTQTPSPLGAVRLKSLGEEEGAHKKTNLPNADSLSDTQLKKKARVC---- 214

  Fly   280 RDELTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGER------------ 332
               |||.|.||.|.:........:            |....||....|:..|:
Mouse   215 ---LTQESRSSPSSQREGPKETKS------------NPGPTALPSLYPSVDEQLLPRKIRLSRSK 264

  Fly   333 -SPSVGSASAAAAAAAVAAAVAAAANR-------SASADGC-SDRGSERGTLERTDSRDDLLQLD 388
             ||.|.:::.::..:..::...|...|       |..|.|. ..:..|...|:.|....|:
Mouse   265 PSPHVYTSTPSSILSGPSSMPTAPGRRLWRQRTVSKEAQGVDKQKPGEVRPLQSTPDPSDV---- 325

  Fly   389 YSNKDNNNSNSSSTGGNNNNNNNNNNNSSSNNNNSSSNRERNNSG-------------ERERERE 440
                              .....|...|......:||:.|....|             |..:|..
Mouse   326 ------------------GKPAENKKQSPELRAPTSSSVEEGQVGRVKLRKIVNGTCWEVVQEPP 372

  Fly   441 RERERDRDRELSTTPVEQLSSSKRRRKNSS------SNCDNS----------LSSSHQDRHYPQD 489
            ....:|..:.|..:.||:.|.:.....|..      ..|.:|          ||:||...|....
Mouse   373 LRNTQDSPQILEPSDVEEPSGTLLSSVNEQEIPARIQLCQDSPESPRLQDILLSASHSPDHPMVK 437

  Fly   490 SQANFKSSPV--------------PKT-------------------GGSTSESED------AGGR 515
            |:  |.|||:              |.|                   ..:|||.|:      .|..
Mouse   438 SE--FGSSPMLTGKESDLNIDCREPYTFDTTLLGQPCEAEQYRITSAAATSELEEIFDFMLCGSD 500

  Fly   516 HDSPLS----------MTTSVHLGGGGGNVGAASA------------LSGL-SQSLSIKQELMD- 556
            .:.|:.          .|.|.||...|.|......            |:|| .:.:|..:|.::
Mouse   501 VEPPVGSLESPGAEGCRTPSYHLSETGKNWIEGEEWCLPDMELWPRDLTGLEKEPVSENKEPVEP 565

  Fly   557 ---AQQQQQHREHHVALPPDYLPSAALKLHAEDMSTL------LTQHALQAADARDEHNDAKQLQ 612
               ...:.::.|....|.|..:||   ::..|::|..      |...:.|..|.:.|    |.|.
Mouse   566 FSPLVMRSENTESFEPLSPLVMPS---EVSREELSLRGSWTPDLEITSSQPLDGQGE----KLLH 623

  Fly   613 LDQTDNIDGRVKCFNIKHDRHP-------------------------DRELDRNHREHDDDPGVI 652
            .|.:|...   :.:|  |...|                         .||:..|..:.|..||..
Mouse   624 FDSSDPSQ---RSYN--HLSPPCSDWAETGLEVSLGMDDVLCPVPKAVREVSANPEQLDPLPGSS 683

  Fly   653 EEVVVDHV 660
            |:..:|.|
Mouse   684 EDEEIDVV 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fru	NP_001163648.1	BTB	126..221	CDD:279045	35/106 (33%)
		BTB	137..221	CDD:197585	33/100 (33%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
Btbd18	NP_001138572.1	BTB_POZ_BTBD18	20..138	CDD:349602	35/109 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..176		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..350		34/202 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..394		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..637		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910