Protein Alignment CG10864 and KCNK12

DIOPT Version :10

• Sequence 1: NP_650726.1
• Gene: CG10864 / 42222
• FlyBaseID: FBgn0038621
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_071338.1
• Gene: KCNK12 / 56660
• HGNCID: 6274
• Length: 430
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 94/410 - (22%)
• Similarity: 149/410 - (36%)
• Gaps: 124/410 - (30%)

  Fly     7 RKPSPGGTVGMGGGPSSVSSTPSNQPRKRVKR------CCR---------NFVTFMCTQVGVGAL 56
            |.|.|                |..:.|:|:.|      |||         .||.       :.||
Human     4 RSPRP----------------PPRRSRRRLPRPSCCCCCCRRSHLNEDTGRFVL-------LAAL 45

  Fly    57 IVIYAICGAFAFMHIERQFVDETAGHVMELRQNCSQQLWSITEQHNIIDRRRWTEATNDVLREYQ 121
            |.:|.:.||..|..:      |:.|.. |.|......|.:.:..|.:.:     ......||.|:
Human    46 IGLYLVAGATVFSAL------ESPGEA-EARARWGATLRNFSAAHGVAE-----PELRAFLRHYE 98

  Fly   122 SQIAGVVKHGYVGRSPEQIWSFPAALMFCLSVITMIGYGNMVPRTPWGKGFTVIYATFGIPLYIL 186
            :.:|..|:...:  .|.  |.||.|..|..:|::.||:|...|.|..||.|.:.|..||....||
Human    99 AALAAGVRADAL--RPR--WDFPGAFYFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTIL 159

  Fly   187 YF-LNMGRVLARSFKFLYRSLHDCTQEHPR--------------LDRMDALEGGVGMTRKKVIVP 236
            :| |.:.|::: ...|:.|:   |.:...|              |...|:|.|.      |..|.
Human   160 FFNLFLERIIS-LLAFIMRA---CRERQLRRSGLLPATFRRGSALSEADSLAGW------KPSVY 214

  Fly   237 STACLWVIFFYVLT--GTVMFANWEKWSLLNSFYFCMTSLCKIGFGDFVPGASLTTSADVNAATQ 299
            ....:..:|..:|:  .:.|:.:.|.|..::|.|||..:...|||||.|   |...:|..|....
Human   215 HVLLILGLFAVLLSCCASAMYTSVEGWDYVDSLYFCFVTFSTIGFGDLV---SSQHAAYRNQGLY 276

  Fly   300 KLQEDISADPAELAQLQSVAADQHSKLAINFVYMLLGMGLVAMCRN----LMREEVRLKAREMRE 360
            :|.                          ||:::|||:..:....|    |:::.:....|::
Human   277 RLG--------------------------NFLFILLGVCCIYSLFNVISILIKQVLNWMLRKL-- 313

  Fly   361 DAKLCMEDTRLRFVGCCGNP 380
            ..:.|..        ||..|
Human   314 SCRCCAR--------CCPAP 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10864	NP_650726.1	Ion_trans_2	<141..197	CDD:462301	22/56 (39%)
		Ion_trans_2	242..>284	CDD:462301	14/43 (33%)
KCNK12	NP_071338.1	ER retention/retrieval signal. /evidence=ECO:0000269|PubMed:24163367	11..16		1/4 (25%)
		Ion_trans_2	100..169	CDD:462301	25/72 (35%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	129..134		2/4 (50%)
		Ion_trans_2	222..304	CDD:462301	26/110 (24%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	256..261		3/4 (75%)