Protein Alignment CG10864 and KCNK9

DIOPT Version :10

• Sequence 1: NP_650726.1
• Gene: CG10864 / 42222
• FlyBaseID: FBgn0038621
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_001269463.1
• Gene: KCNK9 / 51305
• HGNCID: 6283
• Length: 374
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 78/331 - (23%)
• Similarity: 131/331 - (39%)
• Gaps: 86/331 - (25%)

  Fly    41 RNFVTFMCTQVGVGALIVIYAICGAFAFMHIERQFVDETAGHVMELRQNCSQQLWSITEQHNIID 105
            |.....:||        ..|.:.||..|..:|       :.|.|...:....:...|..::||..
Human     7 RTLSLIVCT--------FTYLLVGAAVFDALE-------SDHEMREEEKLKAEEIRIKGKYNISS 56

  Fly   106 RRRWTEATNDVLREYQSQIAGVVKHGYVGRSPEQIWSFPAALMFCLSVITMIGYGNMVPRTPWGK 170
                        .:|: |:..|:......|:..| |.|..:..|.::|||.||||:..|.|..||
Human    57 ------------EDYR-QLELVILQSEPHRAGVQ-WKFAGSFYFAITVITTIGYGHAAPGTDAGK 107

  Fly   171 GFTVIYATFGIPLYILYFLNMGRVLARSFKFLYRSLHDCTQEHPRLDRMDALEGGVGMTRKKVIV 235
            .|.:.||..||||.::.|.::|..:....::|.:.:..|                .||....|
Human   108 AFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKC----------------CGMRNTDV-- 154

  Fly   236 PSTACLWVIFFYVLTGTV-----MFANWEKWSLLNSFYFCMTSLCKIGFGDFVPGASLTTSADVN 295
             |...:..:.|:...||:     .|:..|:||..:::|:|..:|..|||||:|
Human   155 -SMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYV------------ 206

  Fly   296 AATQKLQEDISADPAELAQLQSVAADQHSKL--AINFVYMLLGMGLVAMCRNL-MREEVRLKARE 357
                              .||:..|.|...|  |.:|:|:|:|:.::....|| :...:.:.:.:
Human   207 ------------------ALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSED 253

  Fly   358 MREDAK 363
            .|.||:
Human   254 ERRDAE 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10864	NP_650726.1	Ion_trans_2	<141..197	CDD:462301	23/55 (42%)
		Ion_trans_2	242..>284	CDD:462301	15/46 (33%)
KCNK9	NP_001269463.1	Ion_trans_2	<73..132	CDD:462301	25/59 (42%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430	93..98		3/4 (75%)
		Ion_trans_2	<183..243	CDD:462301	23/89 (26%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430	199..204		3/4 (75%)
		X-gate. /evidence=ECO:0000269|PubMed:38630723	243..248		0/4 (0%)