DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10864 and KCNK4

DIOPT Version :10

Sequence 1:NP_650726.1 Gene:CG10864 / 42222 FlyBaseID:FBgn0038621 Length:389 Species:Drosophila melanogaster
Sequence 2:NP_201567.1 Gene:KCNK4 / 50801 HGNCID:6279 Length:393 Species:Homo sapiens


Alignment Length:574 Identity:109/574 - (18%)
Similarity:198/574 - (34%) Gaps:160/574 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 LTQSLPIDEQ----LQIGVRFFDIRL---ELALDINASARQNLAQDPDDSSRKSCFIVHGLYSID 123
            |.:||...||    ||..|....:||   |..|:......|::|::....:.:            
Human   506 LKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGE------------ 558

  Fly   124 CLKLAHQMVDFLVAHKEEVLIL-----NVSHIYRMTEYDFRRFFLHPFSSIAERC-GISLCPTDV 182
                .|.:.|.|...:.:|.:|     |:....|..|        ...||:.||. .:....|:.
Human   559 ----IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE--------KQMSSLKERVKSLQADTTNT 611

  Fly   183 DLRIVTLDELIEKEFRII----------------VVGPSDQDMDGCCFRSAALQNKWPRKNNTSD 231
            |..:.||:|.:..:.|.|                .:....:|:.....:.:.||.....|..:  
Human   612 DTALTTLEEALADKERTIERLKEQRDRDEREKQEEIDTYKKDLKDLREKVSLLQGDLSEKEAS-- 674

  Fly   232 LLVYLQAQIHAPVTPGLRVLQGVITPELS-----DIFRNLRSSLKKTFSLPMRG----------- 280
             |:.::....:..:.||:....:.|.|::     :....:.|.|||.....:..           
Human   675 -LLDIKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEATLEARASPEMSDRIQ 738

  Fly   281 LLKEWLQRLDDEEIGNLNILISDQVDTEFCRLVYYLNINEYPEHKLDSYSVNPYLEN-KPRALKT 344
            .|:..:.|..||         |.:..||..||:..|  .|....|.|.......||: ..|.:|.
Human   739 QLEREISRYKDE---------SSKAQTEVDRLLEIL--KEVENEKNDKDKKIAELESLTSRQVKD 792

  Fly   345 KNWD-AEITYPTPPESDKKERSVLNE-------------PLEDGENEPEFLIEEIFDEFEVPVSS 395
            :|.. |.:.:....|. ||...:|.|             .|:|...:.:..|||:          
Human   793 QNKKVANLKHKEQVEK-KKSAQMLEEARRREDSLSDSSQQLQDSLRKKDDRIEEL---------- 846

  Fly   396 IPPKKPIRTSVMV-QQVEMVLDESTSSEDTSLILPRSPIPPPKPKRFSQRIPLVMEVQQIPDDDF 459
               ::.:|.||.: .:.||||.:..|:...:            .|:..:   |:|.::::..:..
Human   847 ---EEALRESVQITAEREMVLAQEESARTNA------------EKQVEE---LLMAMEKVKQELE 893

  Fly   460 PYSDAPCVPFSRSSDTPVRIALPVTEEELRLAALGEYPRYGSQRSQRSQLSPRIEEKKDDNLNGV 524
            ...       ::.|.|...:|    |:|..|..|        :..:|..|...:|.|::..|..:
Human   894 SMK-------AKLSSTQQSLA----EKETHLTNL--------RAERRKHLEEVLEMKQEALLAAI 939

  Fly   525 EEKDGS------------DDDEAPLISHEVESMVEDLIINSTIDAMDNLADRFK 566
            .|||.:            ..:|...:..|.:.:|:.| ...|.:.|..:||.::
Human   940 SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQL-KQQTQNRMKLMADNYE 992

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10864NP_650726.1 Ion_trans_2 <141..197 CDD:462301 14/61 (23%)
Ion_trans_2 242..>284 CDD:462301 9/57 (16%)
KCNK4NP_201567.1 Ion_trans_2 <88..142 CDD:462301
Selectivity filter 1. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 103..108
Ion_trans_2 180..258 CDD:462301
Selectivity filter 2. /evidence=ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157 212..217
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 285..393
Blue background indicates that the domain is not in the aligned region.

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