DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10864 and KCNK2

DIOPT Version :10

Sequence 1:NP_650726.1 Gene:CG10864 / 42222 FlyBaseID:FBgn0038621 Length:389 Species:Drosophila melanogaster
Sequence 2:NP_001017425.2 Gene:KCNK2 / 3776 HGNCID:6277 Length:426 Species:Homo sapiens


Alignment Length:239 Identity:69/239 - (28%)
Similarity:110/239 - (46%) Gaps:36/239 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 LIVIYAICGAFAFMHIERQFVDETAGHVMELRQNCSQQLWSITEQHNIIDRRRWTEATNDVLREY 120
            ::|:|.|.||..|..:|:.       |.:..|.....|..:...||:.::.   ||     |.|.
Human    68 VVVLYLIIGATVFKALEQP-------HEISQRTTIVIQKQTFISQHSCVNS---TE-----LDEL 117

  Fly   121 QSQIAGVVKHGYV--GRSPEQI--WSFPAALMFCLSVITMIGYGNMVPRTPWGKGFTVIYATFGI 181
            ..||...:..|.:  |.:..||  |...::..|..:|||.||:||:.|||..||.|.:|||..||
Human   118 IQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGI 182

  Fly   182 PLYILYFLNMGRVLARSFKFLYRSLHDCTQEHPRLDRMDALEGGVGMTRKKVIVPSTACLWVIF- 245
            ||:......:|..|...|......:.|           ..::..|..|:.::|   :..::::| 
Human   183 PLFGFLLAGVGDQLGTIFGKGIAKVED-----------TFIKWNVSQTKIRII---STIIFILFG 233

  Fly   246 --FYVLTGTVMFANWEKWSLLNSFYFCMTSLCKIGFGDFVPGAS 287
              .:|....::|.:.|.||.|::.||.:.:|..|||||:|.|.|
Human   234 CVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGS 277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10864NP_650726.1 Ion_trans_2 <141..197 CDD:462301 24/55 (44%)
Ion_trans_2 242..>284 CDD:462301 15/44 (34%)
KCNK2NP_001017425.2 Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6 17..38
Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6 51..61
Ion_trans_2 <138..196 CDD:462301 25/57 (44%)
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:Q920B6 157..162 2/4 (50%)
Ion_trans_2 234..312 CDD:462301 17/44 (39%)
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q920B6 266..271 3/4 (75%)
Interaction with AKAP5. /evidence=ECO:0000250|UniProtKB:P97438 313..326
Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250|UniProtKB:P97438 337..385
Blue background indicates that the domain is not in the aligned region.

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