Protein Alignment CG10864 and KCNK18

DIOPT Version :10

• Sequence 1: NP_650726.1
• Gene: CG10864 / 42222
• FlyBaseID: FBgn0038621
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_862823.1
• Gene: KCNK18 / 338567
• HGNCID: 19439
• Length: 384
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 90/433 - (20%)
• Similarity: 141/433 - (32%)
• Gaps: 184/433 - (42%)

  Fly    29 SNQPRKRVKRCCRNF-------VTFMCTQVGVGALIVIYAICGAFAFMHIE-------------R 73
            |..|:.|  |||...       :.|:|       .:|.||:.||..|..||             .
Human     4 SGHPQAR--RCCPEALGKLFPGLCFLC-------FLVTYALVGAVVFSAIEDGQVLVAADDGEFE 59

  Fly    74 QFVDETAGHVMELRQNCSQQLWSITEQHNIIDRRRWTEATNDVLREYQSQIAGVVKHGYVGRSPE 138
            :|::|....:     |||:.:        :.||::      |:....|.     ||..:..|:..
Human    60 KFLEELCRIL-----NCSETV--------VEDRKQ------DLQGHLQK-----VKPQWFNRTTH 100

  Fly   139 QIWSFPAALMFCLSVITMIGYGNMVPRTPWGKGFTVIYATFGIPLYILYFLNMGRVLA------- 196
              |||.::|.||.:|.:.:|||.:.|.|..||...::||.|||||..|...:.|.:||
Human   101 --WSFLSSLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSY 163

  Fly   197 ---RSFKFLYRSL--------------------------------------------HDCTQEHP 214
               |.|.|..|.|                                            ..|:.|
Human   164 NRFRKFPFFTRPLLSKWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCPSRPSCSME-- 226

  Fly   215 RLDRMDALE----------------------------------GGVGMTRKKVIVPSTACLWVIF 245
            ..:|..|||                                  ..||...:::.:|......::|
Human   227 LFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQVERLDIPLPIIALIVF 291

  Fly   246 FYVLTGTVMFANWE-KWSLLNSFYFCMTSLCKIGFGDFVPGASLTTSADVNAATQKLQEDISADP 309
            .|:.....:...|| :....|:||||..:|..|||||.|.
Human   292 AYISCAAAILPFWETQLDFENAFYFCFVTLTTIGFGDTVL------------------------- 331

  Fly   310 AELAQLQSVAADQHSKLAINF-VYMLLGMGLVAMCRNLMREEV 351
                        :|....:.| :|:::||.:|.:...|::..:
Human   332 ------------EHPNFFLFFSIYIIVGMEIVFIAFKLVQNRL 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10864	NP_650726.1	Ion_trans_2	<141..197	CDD:462301	25/65 (38%)
		Ion_trans_2	242..>284	CDD:462301	15/42 (36%)
KCNK18	NP_862823.1	Ion_trans_2	94..155	CDD:462301	24/62 (39%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:36426390	116..121		2/4 (50%)
		Interaction with calcineurin. /evidence=ECO:0000250|UniProtKB:Q6VV64	200..205		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000250|UniProtKB:Q6VV64	249..254		0/4 (0%)
		Ion_trans_2	285..364	CDD:462301	23/115 (20%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:36426390	323..328		3/4 (75%)