DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10864 and Kcnk2

DIOPT Version :10

Sequence 1:NP_650726.1 Gene:CG10864 / 42222 FlyBaseID:FBgn0038621 Length:389 Species:Drosophila melanogaster
Sequence 2:NP_742039.1 Gene:Kcnk2 / 170899 RGDID:621448 Length:426 Species:Rattus norvegicus


Alignment Length:298 Identity:80/298 - (26%)
Similarity:130/298 - (43%) Gaps:51/298 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 PGGTVGMGGGPSSV---SSTPSNQPR-----------KRVKRCCRNFVTFMCTQVGVGALIVIYA 61
            ||.|.|: ..|..:   |:..:::||           .||:......|....|...:..::|:|.
  Rat    10 PGYTAGV-AAPDLLDPKSAAQNSKPRLSFSAKPTVLASRVESDSAINVMKWKTVSTIFLVVVLYL 73

  Fly    62 ICGAFAFMHIERQFVDETAGHVMELRQNCSQQLWSITEQHNIIDRRRWTEATNDVLREYQSQIAG 126
            |.||..|..:|:.             |..||:...:.::.|.|.:.....:|.  |.|...||..
  Rat    74 IIGATVFKALEQP-------------QEISQRTTIVIQKQNFIAQHACVNSTE--LDELIQQIVT 123

  Fly   127 VVKHGYV--GRSPEQI--WSFPAALMFCLSVITMIGYGNMVPRTPWGKGFTVIYATFGIPLYILY 187
            .:..|.:  |.:..|:  |...::..|..:|||.||:||:.|||..||.|.:|||..||||:...
  Rat   124 AINAGIIPLGNNSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFL 188

  Fly   188 FLNMGRVLARSFKFLYRSLHDCTQEHPRLDRMDALEGGVGMTRKKVIVPSTACLWVIF---FYVL 249
            ...:|..|...|......:.|           ..::..|..|:.::|   :..::::|   .:|.
  Rat   189 LAGVGDQLGTIFGKGIAKVED-----------TFIKWNVSQTKIRII---STIIFILFGCVLFVA 239

  Fly   250 TGTVMFANWEKWSLLNSFYFCMTSLCKIGFGDFVPGAS 287
            ...|:|.:.|.||.|::.||.:.:|..|||||:|.|.|
  Rat   240 LPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGS 277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10864NP_650726.1 Ion_trans_2 <141..197 CDD:462301 24/55 (44%)
Ion_trans_2 242..>284 CDD:462301 16/44 (36%)
Kcnk2NP_742039.1 Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000269|PubMed:23021213 17..38 4/20 (20%)
Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000269|PubMed:23021213 51..61 1/9 (11%)
Ion_trans_2 <138..196 CDD:462301 24/57 (42%)
Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430 157..162 2/4 (50%)
Ion_trans_2 234..312 CDD:462301 18/44 (41%)
Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430 266..271 3/4 (75%)
Interaction with AKAP5. /evidence=ECO:0000250|UniProtKB:P97438 313..326
Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250|UniProtKB:P97438 337..385
Blue background indicates that the domain is not in the aligned region.

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