Protein Alignment CG10864 and Kcnk2

DIOPT Version :10

• Sequence 1: NP_650726.1
• Gene: CG10864 / 42222
• FlyBaseID: FBgn0038621
• Length: 389
• Species: Drosophila melanogaster
• Sequence 2: NP_001153322.1
• Gene: Kcnk2 / 16526
• MGIID: 109366
• Length: 426
• Species: Mus musculus
• Alignment Length: 298
• Identity: 80/298 - (26%)
• Similarity: 129/298 - (43%)
• Gaps: 51/298 - (17%)

  Fly    11 PGGTVGMGGGPSSV---SSTPSNQPR-----------KRVKRCCRNFVTFMCTQVGVGALIVIYA 61
            ||.|.|: ..|..:   |:..:::||           .||:......|....|...:..::|:|.
Mouse    10 PGYTAGV-AAPDLLDPKSAAQNSKPRLSFSSKPTVLASRVESDSAINVMKWKTVSTIFLVVVLYL 73

  Fly    62 ICGAFAFMHIERQFVDETAGHVMELRQNCSQQLWSITEQHNIIDRRRWTEATNDVLREYQSQIAG 126
            |.||..|..:|:.             |..||:...:.::...|.:.....:|.  |.|...||..
Mouse    74 IIGATVFKALEQP-------------QEISQRTTIVIQKQTFIAQHACVNSTE--LDELIQQIVA 123

  Fly   127 VVKHGYV--GRSPEQI--WSFPAALMFCLSVITMIGYGNMVPRTPWGKGFTVIYATFGIPLYILY 187
            .:..|.:  |.|..|:  |...::..|..:|||.||:||:.|||..||.|.:|||..||||:...
Mouse   124 AINAGIIPLGNSSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFL 188

  Fly   188 FLNMGRVLARSFKFLYRSLHDCTQEHPRLDRMDALEGGVGMTRKKVIVPSTACLWVIF---FYVL 249
            ...:|..|...|......:.|           ..::..|..|:.::|   :..::::|   .:|.
Mouse   189 LAGVGDQLGTIFGKGIAKVED-----------TFIKWNVSQTKIRII---STIIFILFGCVLFVA 239

  Fly   250 TGTVMFANWEKWSLLNSFYFCMTSLCKIGFGDFVPGAS 287
            ...|:|.:.|.||.|::.||.:.:|..|||||:|.|.|
Mouse   240 LPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGS 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10864	NP_650726.1	Ion_trans_2	<141..197	CDD:462301	24/55 (44%)
		Ion_trans_2	242..>284	CDD:462301	16/44 (36%)
Kcnk2	NP_001153322.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		8/26 (31%)
		Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6	17..38		4/20 (20%)
		Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6	51..61		1/9 (11%)
		Ion_trans_2	<138..196	CDD:462301	24/57 (42%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:Q920B6	157..162		2/4 (50%)
		Ion_trans_2	234..312	CDD:462301	18/44 (41%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q920B6	266..271		3/4 (75%)
		Interaction with AKAP5. /evidence=ECO:0000305|PubMed:17110924	298..311
		Interaction with AKAP5. /evidence=ECO:0000305|PubMed:17110924	313..326
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000269|PubMed:10321245	337..385