Protein Alignment MEOX1 and E5

DIOPT Version :10

• Sequence 1: NP_004518.1
• Gene: MEOX1 / 4222
• HGNCID: 7013
• Length: 254
• Species: Homo sapiens
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 79/305 - (25%)
• Similarity: 115/305 - (37%)
• Gaps: 98/305 - (32%)

Human     2 DPAAS-----SCMRSLQPPAPVWGCLRN---PHSEGNGASGLPHYPPTPFSFHQKPDFLATATAA 58
            ||::.     :.:|.|..|||....:.|   |::.....:|.|| ||:     |.|.|||.
  Fly   144 DPSSGTGNPPTLIRPLPLPAPNLALIGNRTSPNAMAVRMAGPPH-PPS-----QPPPFLAA---- 198

Human    59 YPDFSASCLAATPHSLPQEEHIFTEQHPAFPQSPNWHFPVSDARRRPNSGPAGGSKEMGTSSLGL 123
              .|..:  ||..|...|::....:|.|..|..|. |.|      .|:..|       |...||:
  Fly   199 --QFQMA--AALAHHHQQQQQQQQQQLPPVPTGPP-HGP------HPHLPP-------GQIPLGI 245

Human   124 VDTTGG------PGDDYGVLGSTANETEKKSSRRRKESSD------NQENRGKP--------EGS 168
            .  .||      |...:...||..:..        ::|..      ::..|..|        :..
  Fly   246 F--PGGPHPGHPPPHGHHPFGSAPHLI--------RDSYPLYPWLLSRHGRIFPRFPGNFLFQPF 300

Human   169 SKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWFQNRRMKWKRVK--- 230
            .|.::.||||:..||.:||..|..::|:....|.::|..|.|:|.||||||||||.|.||::
  Fly   301 RKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEG 365

Human   231 -----------------------------GGQPISPNGQDPEDGD 246
                                         |.|....:.:||||.|
  Fly   366 GDGSDTKSNKGSSSGGGGGGDGEDDAKHDGSQHSYEDAEDPEDED 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEOX1	NP_004518.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	86..178		21/111 (19%)
		Homeodomain	172..228	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..254		9/52 (17%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	26/55 (47%)