DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr37 and AT5G40880

DIOPT Version :9

Sequence 1:	NP_650723.1	Gene:	Wdr37 / 42218	FlyBaseID:	FBgn0038617	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_198904.1	Gene:	AT5G40880 / 834089	AraportID:	AT5G40880	Length:	472	Species:	Arabidopsis thaliana

Alignment Length:	439	Identity:	87/439 - (19%)
Similarity:	142/439 - (32%)	Gaps:	154/439 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DIATTTKESLIPPDAR---SAAGGSMSTQASSAALATPATQTDEVAGSFLAAASSTHKSL----- 113
            ::..|:||...|...|   :||.||...|               |.|:....::...|:.
plant    79 NLVWTSKEYKSPEGNRPRQNAANGSAKPQ---------------VIGTGHRVSNQPRKNAVYGPR 128

  Fly   114 KAKLSSATG------GSKAKA-------SNKIKAQTSRIVSSFKA-PTVVSTVVREFGGHKDGIW 164
            .:.||...|      ||..|:       .|..|.:..:.:.|:.. |.:......|  |||:.|.
plant   129 SSSLSDTRGCGPRLNGSPKKSVCNFWKDGNCKKGEKCQFLHSWSCFPGLAMVAALE--GHKNDIK 191

  Fly   165 QVAAKAGQPIIGTASADHTACIWGVESARCL--LQYQGHAGSV------------NSIK-FHQQR 214
            .:|...|...:.:.|.|.|..||...|.:|:  :..|..|||:            |::| |:.|.
plant   192 GIALPQGSDKLFSVSGDGTLLIWDCNSGQCVRSINLQAEAGSLISEGPWVFLGLPNAVKAFNVQN 256

  Fly   215 D--------------------LVLTGSGDGTAHIWQAAVNWEVPKKGHSSEEELDDSDEQVEDRD 259
            .                    ::..|:..|:..:|:|.                 ||:..
plant   257 SKDVHLEGVVGQVHAMTAANGMLFAGTSSGSILVWKAT-----------------DSESD----- 299

  Fly   260 RVDTLRTPLCEFTGPGGHLSVVVAADWLSSMDQIITGSWDRTAILWDVETGLPLQPLTGHDHELT 324
                   |....|...||.|..|.. ::...:.:.:||.|:|..:||:.|
plant   300 -------PFKYLTSLEGHHSGEVTC-FVVGGEVLYSGSVDKTIKVWDLNT--------------- 341

  Fly   325 HVSAHPTQRLVVTASRDTTFRLWDFREAIPAVSVFQGHTETVTSSVFARDDKVVSGSDDRTIKVW 389
                                        :......:.|..||| |:...|..::|.|.|.|||:|
plant   342 ----------------------------LQCRMTLKQHIGTVT-SLLCWDKCLISSSLDGTIKLW 377

  Fly   390 ELRNMRS--ALATIRTDSSVNRLA----VSTGGIIAIPHDNRQIRLFDL 432
            ......|  .:.|.:.:.||:.|.    .....|:...:.|..:.:|||
plant   378 ACSENESLKVVQTRKQELSVHTLCGMHDAEAKPIMFCSYQNGAVGIFDL 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr37	NP_650723.1	WD40	153..476	CDD:238121	64/321 (20%)
		WD40 repeat	164..200	CDD:293791	9/37 (24%)
		WD40	198..>481	CDD:225201	50/274 (18%)
		WD40 repeat	205..274	CDD:293791	12/101 (12%)
		WD40 repeat	282..317	CDD:293791	8/34 (24%)
		WD40 repeat	323..360	CDD:293791	0/36 (0%)
		WD40 repeat	366..403	CDD:293791	13/38 (34%)
		WD40 repeat	407..430	CDD:293791	4/26 (15%)
		WD40 repeat	452..481	CDD:293791
AT5G40880	NP_198904.1	ZnF_C3H1	145..170	CDD:214632	4/24 (17%)
		WD40	168..472	CDD:225201	66/335 (20%)
		WD40	179..465	CDD:295369	64/324 (20%)
		WD40 repeat	270..310	CDD:293791	8/68 (12%)
		WD40 repeat	315..349	CDD:293791	8/77 (10%)
		WD40 repeat	356..396	CDD:293791	12/40 (30%)
		WD40 repeat	403..437	CDD:293791	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19855
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010