Protein Alignment Wdr37 and wdr-37

DIOPT Version :9

• Sequence 1: NP_650723.1
• Gene: Wdr37 / 42218
• FlyBaseID: FBgn0038617
• Length: 487
• Species: Drosophila melanogaster
• Sequence 2: NP_498204.1
• Gene: wdr-37 / 175774
• WormBaseID: WBGene00015470
• Length: 486
• Species: Caenorhabditis elegans
• Alignment Length: 492
• Identity: 193/492 - (39%)
• Similarity: 266/492 - (54%)
• Gaps: 84/492 - (17%)

  Fly    23 EDAPFRARLHVLFAQIEREFEQLYLENQALQEKLDIATTTKESLIPPDARSAAGGSMSTQASSAA 87
            :|||:||||:.||..||:||:.||.||.||..:..|...|:                 |:..:|.
 Worm    41 DDAPYRARLYQLFGHIEKEFDTLYAENCALSVRARIVQLTQ-----------------TEGEAAN 88

  Fly    88 LATPATQTDEVAGSFLAAASSTHKSLK--AKLSSATGGSKAKASNKIKAQTSRIVSSFKAPTVVS 150
            :.     ..||.| ...:..|:.|:::  .||.:|..|........ |.:.||::.
 Worm    89 VV-----AQEVFG-VQESGKSSRKAIQMGQKLRTALRGPPVFRDGS-KFRLSRLLE--------- 137

  Fly   151 TVVREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQRD 215
                   |||||:|.|||.:.:.|..:||||.||.||.:||..||..|.||.||||.:.......
 Worm   138 -------GHKDGVWHVAADSTRNICASASADQTARIWSLESGACLATYTGHTGSVNCVAISNNCA 195

  Fly   216 -------------LVLTGSGDGTAHIWQAAVNWEVPKKGHSSEEELD-----------------D 250
                         |:.|.|||.:.|||:...| ..| ..||||||.:                 .
 Worm   196 VDSTEGSGPASGLLLATASGDESTHIWKVPSN-NAP-SDHSSEEEEEHHRDPNNLLGVVEHNRFT 258

  Fly   251 SDEQVEDRDRVDTLRTPLCEFTGPGGHLSVVVAADWLSSMDQIITGSWDRTAILWDVETGLPLQP 315
            |..:..|..|:   |.|:...|   ||.:.|...:||:...|::|.||||||.:||||.|..:..
 Worm   259 SSSEKSDGHRI---RVPVMRLT---GHRAPVSCCEWLAGGQQMVTASWDRTANVWDVEKGEVVNI 317

  Fly   316 LTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAIPAVSVFQGHTETVTSSVFARDDKVVSG 380
            |:||:.||.|.|.|..|:||:|:|:|:|||||||||||.:|:|||||.::|||..|..|.::||.
 Worm   318 LSGHESELNHCSTHSNQKLVLTSSKDSTFRLWDFREAIQSVAVFQGHQDSVTSVSFNTDYRIVSS 382

  Fly   381 SDDRTIKVWELRNMRSALATIRTDSSVNRLAVS-TGGIIAIPHDNRQIRLFDLNGQRVARLPRTS 444
            |||.|:|:|:|||||:.|||||..|..||:|:| :..:||||.|||.:|::||||.|:.|:|  :
 Worm   383 SDDATVKIWDLRNMRTPLATIRLSSPANRVAISKSHPVIAIPMDNRHVRIYDLNGNRLPRMP--N 445

  Fly   445 RQGHRRMVSSVAWAEEPLLDCDLFSCGFDRRVFGWSI 481
            |:.|.|||:..||.:|...: :|.:.||||.|..|.:
 Worm   446 RRCHERMVTCCAWLDEHPAN-NLLTAGFDRMVAAWKV 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr37	NP_650723.1	WD40	153..476	CDD:238121	156/353 (44%)
		WD40 repeat	164..200	CDD:293791	18/35 (51%)
		WD40	198..>481	CDD:225201	136/313 (43%)
		WD40 repeat	205..274	CDD:293791	24/98 (24%)
		WD40 repeat	282..317	CDD:293791	15/34 (44%)
		WD40 repeat	323..360	CDD:293791	23/36 (64%)
		WD40 repeat	366..403	CDD:293791	22/36 (61%)
		WD40 repeat	407..430	CDD:293791	12/23 (52%)
		WD40 repeat	452..481	CDD:293791	11/28 (39%)
wdr-37	NP_498204.1	WD40	131..392	CDD:238121	114/284 (40%)
		WD40 repeat	186..278	CDD:293791	23/99 (23%)
		WD40 repeat	283..319	CDD:293791	16/35 (46%)
		PTZ00420	307..>486	CDD:240412	94/178 (53%)
		WD40 repeat	326..362	CDD:293791	22/35 (63%)
		WD40 repeat	368..403	CDD:293791	20/34 (59%)
		WD40 repeat	409..445	CDD:293791	19/37 (51%)
		WD40 repeat	453..479	CDD:293791	10/26 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159709
Domainoid	1	1.000	85	1.000	Domainoid score	I5228
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40914
Inparanoid	1	1.050	305	1.000	Inparanoid score	I1593
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52450
OrthoDB	1	1.010	-	-		D1338925at2759
OrthoFinder	1	1.000	-	-		FOG0004215
OrthoInspector	1	1.000	-	-		oto20124
orthoMCL	1	0.900	-	-		OOG6_105847
Panther	1	1.100	-	-	LDO	PTHR19855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4175
SonicParanoid	1	1.000	-	-		X4028
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940