DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-2 and VPH1

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_014913.3	Gene:	VPH1 / 854444	SGDID:	S000005796	Length:	840	Species:	Saccharomyces cerevisiae

Alignment Length:	850	Identity:	341/850 - (40%)
Similarity:	496/850 - (58%)	Gaps:	62/850 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKIRYI 68
            :|||.||||.|.:|..|.:..|...||:.|.|||||||..|.||||.||.|:||.|.:||:.||.
Yeast     8 IFRSAEMALVQFYIPQEISRDSAYTLGQLGLVQFRDLNSKVRAFQRTFVNEIRRLDNVERQYRYF 72

  Fly    69 ETEIKKDGIVLPDIQDD----------IPRAPNPREIIDLEAHLEKTESEMIEL--AQNEVNMKS 121
            .:.:||..|.|.:...|          :|  |:...|.|...:....|..:|::  |.:::.::.
Yeast    73 YSLLKKHDIKLYEGDTDKYLDGSGELYVP--PSGSVIDDYVRNASYLEERLIQMEDATDQIEVQK 135

  Fly   122 NYLELTELRKVLENTQGFFSDQEVLNLDSSN-------RAGGDNDAAAQHRGRLGFVAGVINRER 179
            |.||  :.|.:|::...||...:  |.||::       .|.|:|.||| ....:.:|.|||.|::
Yeast   136 NDLE--QYRFILQSGDEFFLKGD--NTDSTSYMDEDMIDANGENIAAA-IGASVNYVTGVIARDK 195

  Fly   180 VFAFERMLWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASL 244
            |...|::|||:.|||:|.|..::::|:.|..|....:|..|:.|..|:.:..||:|:.....|:|
Yeast   196 VATLEQILWRVLRGNLFFKTVEIEQPVYDVKTREYKHKNAFIVFSHGDLIIKRIRKIAESLDANL 260

  Fly   245 YPCPSSHNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNL 309
            |...||:..|.:.:..|...|.||..||..|.......|..::|.|.||...|.:.|||:..||.
Yeast   261 YDVDSSNEGRSQQLAKVNKNLSDLYTVLKTTSTTLESELYAIAKELDSWFQDVTREKAIFEILNK 325

  Fly   310 FNMDVTKKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGF 374
            .|.|..:|.||.|.|:|.::|..:|..|.:..|.:|..:||.:.|:|||..||||:||||||.||
Yeast   326 SNYDTNRKILIAEGWIPRDELATLQARLGEMIARLGIDVPSIIQVLDTNHTPPTFHRTNKFTAGF 390

  Fly   375 QNLIDAYGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEI 439
            |::.|.||:|.|||.|..|.|.:||||:||:||||:|||.::.|....:||.|:|:.:::. |||
Yeast   391 QSICDCYGIAQYREINAGLPTIVTFPFMFAIMFGDMGHGFLMTLAALSLVLNEKKINKMKR-GEI 454

  Fly   440 WNIFFGGRYIILLMGLFAMYTGLVYNDVFSKSMNLF--GSRWFNNYNTTTVLTNPNLQLPPNSSA 502
            :::.|.|||||||||:|:||||.:|||:|||:|.:|  |.:|.:::.....:|         :::
Yeast   455 FDMAFTGRYIILLMGVFSMYTGFLYNDIFSKTMTIFKSGWKWPDHWKKGESIT---------ATS 510

  Fly   503 VGVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQ 567
            ||.||.|:|..|...:|.::|.||:||||||:.|.:||.:....|:.|..:|.....|...|:|.
Yeast   511 VGTYPIGLDWAWHGTENALLFSNSYKMKLSILMGFIHMTYSYFFSLANHLYFNSMIDIIGNFIPG 575

  Fly   568 ILFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFES 632
            :||:..:|||:...:.:||    |....:...|  ||.:|.|.|||.|     .|...::.::..
Yeast   576 LLFMQGIFGYLSVCIVYKW----AVDWVKDGKP--APGLLNMLINMFL-----SPGTIDDELYPH 629

  Fly   633 QPQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAH----ANHNGQLTGNIELAEGETPLPTGFS 693
            |.::|...:|:||.||||:||.|||:.|||.|.|:|    :......:.::|..:..:.:....:
Yeast   630 QAKVQVFLLLMALVCIPWLLLVKPLHFKFTHKKKSHEPLPSTEADASSEDLEAQQLISAMDADDA 694

  Fly   694 GNEENAGGAHGHDDEPMSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVLS 758
            ..||...|:||.|   ..:|.|||.|||||:.|:.:||||||||||||||||||||.|||.|.:.
Yeast   695 EEEEVGSGSHGED---FGDIMIHQVIHTIEFCLNCVSHTASYLRLWALSLAHAQLSSVLWTMTIQ 756

  Fly   759 LGLKMSGVGGAIGLFI---IFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQ 820
            :..   |..|.:|:|:   :|..|...|.|:||||||.||.||:|||||||.||||:.|.|..::
Yeast   757 IAF---GFRGFVGVFMTVALFAMWFALTCAVLVLMEGTSAMLHSLRLHWVESMSKFFVGEGLPYE 818

  Fly   821 PFSFK 825
            ||:|:
Yeast   819 PFAFE 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	329/823 (40%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	326/817 (40%)
VPH1	NP_014913.3	V_ATPase_I	31..822	CDD:396194	329/824 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344194
Domainoid	1	1.000	584	1.000	Domainoid score	I29
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	609	1.000	Inparanoid score	I127
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	1	1.010	-	-		QHG53812
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm9226
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
TreeFam	1	0.960	-	-
	14	13.710