DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-2 and atp6v0a1b

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_009295518.1	Gene:	atp6v0a1b / 553691	ZFINID:	ZDB-GENE-050522-215	Length:	868	Species:	Danio rerio

Alignment Length:	883	Identity:	458/883 - (51%)
Similarity:	608/883 - (68%)	Gaps:	64/883 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||::||||||.|.|:|:|.||||..||||||.|.|||||||.:||.||||||.|||||:|::||:
Zfish     1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGMVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            |::|.||||..|...|..:: |..|.||::|||||..||.|:|:.|:..|:..:|.|:||||||:
Zfish    66 RFVEKEIKKANIPTMDTGEN-PEVPFPRDMIDLEATFEKLENELKEINTNQEALKKNFLELTELK 129

  Fly   131 KVLENTQGFFSDQEVLNL--DSSNRAGGDNDAAAQHRG---RLGFVAGVINRERVFAFERMLWRI 190
            .:|..||.||.:.|..||  :||:..    |.:...||   |||||||||||||:..|||||||:
Zfish   130 HILRRTQQFFDEMEDPNLLEESSSLL----DPSEAGRGAPLRLGFVAGVINRERIPTFERMLWRV 190

  Fly   191 SRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNERE 255
            .||||||:::::::||.||.||..::|:||:.||||:|||||:||:|.||.|||||||.:..||:
Zfish   191 CRGNVFLRQTEIEDPLEDPTTGDQVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERK 255

  Fly   256 EMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKCLI 320
            ||...|.||::||::||:||||||.|||...:|.:..|.|.|:|||||||||||.|:|||:||||
Zfish   256 EMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKTMRVWFIKVRKMKAIYHTLNLCNIDVTQKCLI 320

  Fly   321 GECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGVAS 385
            .|.|.|.:||..:|.||..|:...|||:||.||.:.|.:.|||:|:|||||.||||::||||:.:
Zfish   321 AEVWCPVSDLDSIQFALRRGTERSGSTVPSILNRMQTKQTPPTYNKTNKFTSGFQNIVDAYGIGT 385

  Fly   386 YRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRYII 450
            |||.|||.||.|||||||||||||:|||:::.....::||.|.:|...::..|::|:.|.|||||
Zfish   386 YREINPAPYTIITFPFLFAVMFGDMGHGVLMTSAALYLVLRETRLLAQKSDNEMFNMIFAGRYII 450

  Fly   451 LLMGLFAMYTGLVYNDVFSKSMNLFGSRWF--------NNYNTTTVLTNPNLQLPPNSSAV--GV 505
            ||||:|::||||:|||.||||:|:|.|.|.        .|:...|:.:|..|||.|:.|.|  |.
Zfish   451 LLMGMFSVYTGLIYNDCFSKSLNMFSSGWSVRPMFAPNGNWTDQTLESNSVLQLNPSVSGVFGGP 515

  Fly   506 YPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQILF 570
            ||.|:||:|.:|.||:.||||||||:|:|.||:||:|||.:|:.|..:||:..:|||.|:|:|:|
Zfish   516 YPLGIDPIWNIAANKLTFLNSFKMKMSVILGVIHMLFGVTLSLFNHLYFKKPLNIFLNFIPEIVF 580

  Fly   571 LLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQPQ 635
            :..||||::.::|:||.:|:|.||..      |||:||.||||.||...:|   .|:.::..|..
Zfish   581 MSSLFGYLILLIFYKWIAYDAVTSKD------APSLLIAFINMCLFNYNDP---TNKPLYRGQAG 636

  Fly   636 LQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHAN--HNGQLTGNIE-LAEGETPLPTGFS---- 693
            :|...|:|||.|:|.||:.|.:.::.....|.|.:  .:.:...|:| |.:..|..|.|.:
Zfish   637 IQSLLVVIALACVPVMLVVKTMILRRQHLWKKHLSQMRDARPAENLETLEQTGTSSPPGLTQQGT 701

  Fly   694 --------GN---EENA--------------GGAHGHDDEPMS--EIYIHQAIHTIEYVLSTISH 731
                    ||   |:.|              |..|. ::||.:  ::.:|||||||||.|..||:
Zfish   702 QKFGGVRVGNGPTEDEAEIIDHDQLSQHSEEGDEHS-EEEPFNFGDMAVHQAIHTIEYCLGCISN 765

  Fly   732 TASYLRLWALSLAHAQLSEVLWQMVLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAF 796
            ||||||||||||||||||||||.||:.|||.....||..||.|||.|:...|:.||::|||||||
Zfish   766 TASYLRLWALSLAHAQLSEVLWGMVMRLGLSSRSGGGFFGLSIIFSAFATLTVCILLIMEGLSAF 830

  Fly   797 LHTLRLHWVEFMSKFYEGMGYAFQPFSFKAILDGEEEE 834
            ||.||||||||.:|||.|.|:.|.||||::||:|..:|
Zfish   831 LHALRLHWVEFQNKFYTGQGFKFVPFSFESILEGRFDE 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	434/844 (51%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	430/838 (51%)
atp6v0a1b	XP_009295518.1	NtpI	27..860	CDD:224188	437/847 (52%)
atp6v0a1b	XP_009295518.1	V_ATPase_I	28..858	CDD:279793	434/844 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582322
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.720