Protein Alignment Vha100-2 and tcirg1

DIOPT Version :10

• Sequence 1: NP_650722.1
• Gene: Vha100-2 / 42216
• FlyBaseID: FBgn0028670
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: XP_012809053.3
• Gene: tcirg1 / 549603
• XenbaseID: XB-GENE-5721917
• Length: 865
• Species: Xenopus tropicalis
• Alignment Length: 846
• Identity: 378/846 - (44%)
• Similarity: 530/846 - (62%)
• Gaps: 43/846 - (5%)

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||.:||.|||.|.|:|:|..:.|..||.|||.|.|:|||||.|||:|||::|:|:|||||:|...
 Frog    43 MGSLFRGEEMCLAQLFLQSGSEYQCVSALGELGLVEFRDLNQNVNSFQRRYVSEIRRCDEMETTF 107

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            .|:|.|::|.|:.:|: .:..|.||.||:.|.::...|:...|:.|::||...::....||.|..
 Frog   108 SYLERELRKAGVQVPE-SEMSPPAPLPRDAIRMQEESEQLAKELREVSQNRQTLQERLRELLEYA 171

  Fly   131 KVLENTQGFFSDQEVLNLDSSNRAGGDN--DAAAQHRG--RLGFVAGVINRERVFAFERMLWRIS 191
            .:|..:|.|............:|:..|.  |.|..::.  |:.|:||||:..|:.:|||:|||..
 Frog   172 NILRESQRFTGPLLESEAQWKDRSEDDPLLDPAVVNKQDLRVSFMAGVIHPWRMNSFERLLWRAC 236

  Fly   192 RGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNEREE 256
            ||.:.:...::.||:.|..||..:.:.:|:..:.||::..:|||:...||..:||.......|.|
 Frog   237 RGYLIVNFVEMSEPMEDLVTGESVTQIIFLISYWGEKIGEKIKKIANCFHCHIYPYADDETSRLE 301

  Fly   257 MVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKCLIG 321
            .:||:..:::|::.||.|||.:.|:||:..:..|..|.:.|:|||.||..|||  ..|.::||||
 Frog   302 TLRNLLVQIQDMQKVLLQTEGYLSQVLSRAASALHHWRVSVRKMKHIYLILNL--CSVRERCLIG 364

  Fly   322 ECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGVASY 386
            |.|.|..|||::|.||:..|.:.|....||.:.|.....|||..||||||.|||.::||||||:|
 Frog   365 EVWCPVVDLPLLQSALTRASESSGGGGESFCHRIPCAFSPPTLIRTNKFTSGFQGIVDAYGVATY 429

  Fly   387 RECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRYIIL 451
            :|.|||:::.|||||||||||||:|||.|:.||..|:||.|......|:..||:::.|||||:||
 Frog   430 QEVNPAIFSIITFPFLFAVMFGDVGHGAIMFLFALWLVLGENDPKLRRSEDEIFSMCFGGRYLIL 494

  Fly   452 LMGLFAMYTGLVYNDVFSKSMNLFGSRW-------FNNYNTTTVLTNPNLQLPPNSSAV--GVYP 507
            |||..::|||.|||:.||:...:|.|.|       .||:.:.::...|.:.|.||.:.|  ..||
 Frog   495 LMGALSVYTGFVYNECFSRPAVIFNSGWSVASMARANNWTSDSINKLPPIPLNPNITGVFTAPYP 559

  Fly   508 FGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQILFLL 572
            ||:||:|.||.|::.||||||||:|:|.||.||.||||:||.||.||::...|||..:|::||||
 Frog   560 FGIDPIWSLAVNRLTFLNSFKMKMSVILGVCHMAFGVCLSVFNFVHFRQIYRIFLITLPELLFLL 624

  Fly   573 LLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQPQLQ 637
            .||||:|||:.:||....|      |....|||:||.||:|.||  |:.|.  |..:::.|..:|
 Frog   625 CLFGYLVFMVVYKWIVLTA------EDAEWAPSILIHFIDMFLF--TQNPG--NRDLYQGQQVVQ 679

  Fly   638 KAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANHNGQLT---GNIE-LAEGETPLPTGFSGNEEN 698
            ...|::|:.|||.:|||.|:.:....::|..::|..:.:   |:.| |.|.|..:|||
 Frog   680 TVLVIVAILCIPVLLLGDPICLLIQHRSKKDSSHQNRCSLNNGDREALLEDEITVPTG------- 737

  Fly   699 AGGAHGHDDEPM--SEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVLSLGL 761
                |||..|..  :|:::||.||||||.|..||:||||||||||||||||||||||.||:.:|.
 Frog   738 ----HGHGSEKFDTAEVFMHQMIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWNMVIRIGF 798

  Fly   762 KMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQPFSFKA 826
            ....:...|.|..||..:.:.|:|||::|||||||||.||||||||.:|||.|.||.|.||.|:.
 Frog   799 SKLSLTWGIVLVPIFAFFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGEGYKFFPFCFET 863

  Fly   827 I 827
            :
 Frog   864 M 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	27..824	CDD:460232	364/815 (45%)
tcirg1	XP_012809053.3	V_ATPase_I	69..861	CDD:460232	364/815 (45%)