DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-2 and atp6v0a2

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001016223.1	Gene:	atp6v0a2 / 548977	XenbaseID:	XB-GENE-960957	Length:	845	Species:	Xenopus tropicalis

Alignment Length:	871	Identity:	399/871 - (45%)
Similarity:	544/871 - (62%)	Gaps:	74/871 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||..||||.|.|.|:|:|..:||..||||||.|..:|||||..|:|||||||.||::|:|:||.:
Frog     1 MGSFFRSEAMCLAQLFLQSGSAYDCVSELGEMGLAEFRDLNPQVSAFQRKFVGEVKKCEEMERIL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            .|:..||:|..|.:|: :...|.||.|:.::|::..|:|.|.|:.|:.:|:..::.|.||:.|..
Frog    66 GYLMQEIQKANIPVPE-ESLTPEAPLPKHVLDIQEQLQKLEVELREVNKNKEKLQKNLLEMIEYT 129

  Fly   131 KVL------------ENTQGFFSDQEVLNLDSSNRAGGDNDAAAQHR--GRLGFVAGVINRERVF 181
            .:|            ..|....:.:|...|:..:..    |.....|  .:||||:|:::|.::.
Frog   130 YMLRVTNYLVHRSNEHETSAHSTYEEFPALEKESLI----DYTCMQRLGAKLGFVSGLVHRAKLE 190

  Fly   182 AFERMLWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYP 246
            :||:||||:.:|...|...:|||.|..|.|..|....|||..:.|:|:..::||:|..:...|||
Frog   191 SFEKMLWRVCKGYTVLTYQELDEYLLHPDTEEPTRWFVFVVSYWGDQIGQKVKKICECYDCHLYP 255

  Fly   247 CPSSHNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFN 311
            ..:|..||..::..:.||::||..|:|||:|:..:||...|:::..|.|.:||||||||.||...
Frog   256 YTNSAEERRNLLSELNTRIQDLHKVISQTDDYLKQVLFKASESVYKWVIQIKKMKAIYHVLNFCR 320

  Fly   312 MDVTKKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQN 376
            .|||.||||.|.|.|..|||.|::||.:||...|.::|||:|.|.:|:.|||..||||||.||||
Frog   321 FDVTNKCLIAEVWCPVADLPNVRRALEEGSRKSGVSVPSFINRIPSNDTPPTLIRTNKFTSGFQN 385

  Fly   377 LIDAYGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCER--KLARIRNGGEI 439
            ::|||||.:|||.|||.||.|||||||||||||.|||:::.||...||:.|:  ||||.::  ||
Frog   386 IVDAYGVGNYREMNPAPYTIITFPFLFAVMFGDFGHGILMSLFALCMVVFEKSPKLARSQD--EI 448

  Fly   440 WNIFFGGRYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRW------FNNYNTTTVLTNPNLQLPP 498
            ...||.|||||||||||::||||:|||.||||||:|||.|      .:|...|..|:|..|.|.|
Frog   449 MKTFFEGRYIILLMGLFSIYTGLIYNDCFSKSMNIFGSSWNVSAMFSSNVWRTQDLSNKFLTLNP 513

  Fly   499 NSSAV--GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIF 561
            |.:.|  ||||.|:||:|.|:.|::.||||||||:|:|.||:||.|||.:|..|:.|||:...||
Frog   514 NVTGVLTGVYPVGIDPIWSLSTNRLSFLNSFKMKMSVILGVIHMTFGVVLSAFNYMHFKKRFCIF 578

  Fly   562 LEFVPQILFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLF-KNTEPPKGC 625
            |.|:|::||::.:|||:|||:.:||.:|:|..|..      |||:|:.||||.:| ||.:.|.
Frog   579 LVFIPELLFMICIFGYLVFMILYKWLAYSAADSRN------APSILLHFINMFMFSKNDQIPA-- 635

  Fly   626 NEFMFESQPQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANHNGQLTGNIELAEGETPLPT 690
               :|..|..:|...:::...|:|.:|.|||||:.:       .:|.||...|..  :|.|.:.
Frog   636 ---LFTGQVGIQIFLIVLVTLCVPVLLFGKPLYLYW-------QHHGGQTLRNYR--KGYTLVR- 687

  Fly   691 GFSGNEENAGGAHGHDDE-------------------PMSEIYIHQAIHTIEYVLSTISHTASYL 736
              .|:||.......||.|                   ..:::::.||||||||.|..||:||.||
Frog   688 --RGSEEEISLVRSHDLEEGEINSSHEVQRDRDKEKFDFADVFMSQAIHTIEYCLGCISNTALYL 750

  Fly   737 RLWALSLAHAQLSEVLWQMVLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLR 801
            |||||||||||||||||.|::..||.:....|...|..:|..:...|:|||::|||||||||.||
Frog   751 RLWALSLAHAQLSEVLWGMIMRKGLNVEPSVGVFVLIPLFAVFAFLTIAILLVMEGLSAFLHALR 815

  Fly   802 LHWVEFMSKFYEGMGYAFQPFSFKAI 827
            ||||||.:|||.|.||.|.|||||.|
Frog   816 LHWVEFQNKFYTGAGYKFNPFSFKHI 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	380/839 (45%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	376/833 (45%)
atp6v0a2	NP_001016223.1	NtpI	27..839	CDD:224188	382/841 (45%)
atp6v0a2	NP_001016223.1	V_ATPase_I	28..838	CDD:279793	380/839 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110