DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-2 and ATP6V0A1

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001365459.1	Gene:	ATP6V0A1 / 535	HGNCID:	865	Length:	903	Species:	Homo sapiens

Alignment Length:	927	Identity:	466/927 - (50%)
Similarity:	607/927 - (65%)	Gaps:	117/927 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||::||||||.|.|:|:|.||||..||||||.|.|||||||.:||.||||||.|||||:|::||:
Human     1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            |::|.||:|..|.:.|..:: |..|.||::|||||:.||.|:|:.|:..|:..:|.|:||||||:
Human    66 RFVEKEIRKANIPIMDTGEN-PEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELK 129

  Fly   131 KVLENTQGFF---SDQEVLNLDSSNRAGGDNDAAAQHRG---RLGFVAGVINRERVFAFERMLWR 189
            .:|..||.||   :|.::|...||..     :.:...||   |||||||||||||:..|||||||
Human   130 FILRKTQQFFDEMADPDLLEESSSLL-----EPSEMGRGTPLRLGFVAGVINRERIPTFERMLWR 189

  Fly   190 ISRGNVFLKRSDLDEPLNDPAT----------------GHP------------------------ 214
            :.||||||::::::.||.||.|                |.|
Human   190 VCRGNVFLRQAEIENPLEDPVTVESHSVVQARVQWRDLGSPQPPLPGFKRFSCLSLPSSWGLQGD 254

  Fly   215 -IYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNEREEMVRNVRTRLEDLKLVLSQTEDH 278
             ::|:||:.||||:|||||:||:|.||.|||||||.:..||:||...|.||::||::||:|||||
Human   255 YVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDH 319

  Fly   279 RSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKCLIGECWVPTNDLPVVQKALSDGSAA 343
            |.|||...:||:..|.|.|:|||||||||||.|:|||:||||.|.|.|..||..:|.||..|:..
Human   320 RQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEH 384

  Fly   344 VGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGVASYRECNPALYTCITFPFLFAVMFG 408
            .|||:||.||.:.||:.|||:|:|||||.||||::||||:.:|||.|||.||.||||||||||||
Human   385 SGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFG 449

  Fly   409 DLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRYIILLMGLFAMYTGLVYNDVFSKSMN 473
            |.|||:::.||..||||.|.::...:|..|:::..|.|||||||||:|:|||||:|||.||||:|
Human   450 DFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLN 514

  Fly   474 LFGSRW----FNNYNTT--TVLTNPNLQLPPNSSAV--GVYPFGMDPVWQLADNKIIFLNSFKMK 530
            :|||.|    ...||.|  |:..||.|||.|....|  |.||||:||:|.:|.||:.||||||||
Human   515 IFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMK 579

  Fly   531 LSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQILFLLLLFGYMVFMMFFKWFSYNARTSF 595
            :|:|.|::||:|||.:|:.|..:||:..:|:..|:|:|:|:..||||:|.::|:||.:|:|.||.
Human   580 MSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSE 644

  Fly   596 QPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQPQLQKAFVLIALCCIPWMLLGKPLYIK 660
            .      |||:||.||||.||..   |:.....::..|..:|...|::||.|:|||||.|||.::
Human   645 N------APSLLIHFINMFLFSY---PESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLR 700

  Fly   661 ---FTRKN-------------------KAHANHNGQLT-GNIELAEGETPLPTGFSGNEENAG-- 700
               ..||:                   :|.|...|.|. |.|.:..|.|         ||:|.
Human   701 RQYLRRKHLEGQPVEAPVSPNPSQQGLEAAAAATGTLNFGGIRVGNGPT---------EEDAEII 756

  Fly   701 -----GAHGHD-DEPM-SEIY------IHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVL 752
                 ..|..| |||. .|::      :|||||||||.|..||:|||||||||||||||||||||
Human   757 QHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVL 821

  Fly   753 WQMVLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGY 817
            |.||:.:||.:..:.|.:.||..|.|:...|:|||::|||||||||.||||||||.:|||.|.|:
Human   822 WTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGF 886

  Fly   818 AFQPFSFKAILDGEEEE 834
            .|.||||:.|.:|:.||
Human   887 KFLPFSFEHIREGKFEE 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	442/888 (50%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	438/882 (50%)
ATP6V0A1	NP_001365459.1	V_ATPase_I	27..893	CDD:396194	443/889 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.670