DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-2 and ATP6V0A4

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_065683.2	Gene:	ATP6V0A4 / 50617	HGNCID:	866	Length:	840	Species:	Homo sapiens

Alignment Length:	859	Identity:	442/859 - (51%)
Similarity:	588/859 - (68%)	Gaps:	44/859 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            |..:||||||.|.|:|:|.||||..|:||||.|.|||:|||:|||:||||||.|||||:.|||.:
Human     1 MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            |::|.|::.:.:|  .:.:..|..|.|||:|.||..|||.|.|:.|..||:..:|.::||||||:
Human    66 RFLEDEMQNEIVV--QLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELK 128

  Fly   131 KVLENTQGFFSDQ-----EVLNLDSSN----RAGGDNDAAAQHRGRLGFVAGVINRERVFAFERM 186
            .:|:.||.||..:     :....|:|.    :|     ..|...|:|||:||||||||:.:|||:
Human   129 YLLKKTQDFFETETNLADDFFTEDTSGLLELKA-----VPAYMTGKLGFIAGVINRERMASFERL 188

  Fly   187 LWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSH 251
            ||||.||||:||.|::|.||.||.|...|.|.:|:.|:|||||:.:|||:|.||.|::||||...
Human   189 LWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPA 253

  Fly   252 NEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTK 316
            .||.||:.:|..|||||..|::|||.||.|:|...:.|..||.|.|:||||:||.||:.|:|||:
Human   254 VERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQ 318

  Fly   317 KCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAY 381
            :|:|.|.|.|..|...:::||..|....||::...:..:.:...|||||||||||.||||::|||
Human   319 QCVIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAY 383

  Fly   382 GVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGG 446
            ||.||||.|||.||.|||||||||||||.|||.:::|...||:|.||:|...:...||||.||.|
Human   384 GVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHG 448

  Fly   447 RYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRW-----FNN--YNTTTVLTNPNLQLPPNSSAV- 503
            ||:|||||:|::||||:|||.||||:|:|||.|     |.|  :||..:..:..|||.|....|
Human   449 RYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIPGVY 513

  Fly   504 --GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVP 566
              ..||||:||:|.||.||:.||||:|||:|:|.|::.|||||.:|:.|..:|:|..:|.|:|:|
Human   514 FGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIP 578

  Fly   567 QILFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFE 631
            :::|:|.||||:|||:.|||..::...|..      |||:||.||||.||..::   ..|..:::
Human   579 EMIFILCLFGYLVFMIIFKWCCFDVHVSQH------APSILIHFINMFLFNYSD---SSNAPLYK 634

  Fly   632 SQPQLQKAFVLIALCCIPWMLLGKPLYIKFT-RKNKAHANH-NGQLTGNIELAEGETPLPTGFSG 694
            .|.::|..||::||..:|||||.||..::.: ||::..|:. ....|.||   ||::..|:..||
Human   635 HQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENI---EGDSSSPSSRSG 696

  Fly   695 NEENA---GGAHGHDDE-PMSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQM 755
            ...:|   |....|.:| ...::::|||||||||.|..||:||||||||||||||||||||||.|
Human   697 QRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTM 761

  Fly   756 VLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQ 820
            |::.||:..|.||.:|:||||..:.:.|:|||::|||||||||.||||||||.:|||.|.||.|.
Human   762 VMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGYKFS 826

  Fly   821 PFSFKAILDGEEEE 834
            |||||.||||..||
Human   827 PFSFKHILDGTAEE 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	417/820 (51%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	413/814 (51%)
ATP6V0A4	NP_065683.2	NtpI	28..831	CDD:224188	418/821 (51%)
		V_ATPase_I	28..830	CDD:279793	417/820 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..704		9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H39904
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.790