Protein Alignment Vha100-2 and ATP6V0A4

DIOPT Version :10

• Sequence 1: NP_650722.1
• Gene: Vha100-2 / 42216
• FlyBaseID: FBgn0028670
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: NP_065683.2
• Gene: ATP6V0A4 / 50617
• HGNCID: 866
• Length: 840
• Species: Homo sapiens
• Alignment Length: 859
• Identity: 442/859 - (51%)
• Similarity: 588/859 - (68%)
• Gaps: 44/859 - (5%)

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            |..:||||||.|.|:|:|.||||..|:||||.|.|||:|||:|||:||||||.|||||:.|||.:
Human     1 MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            |::|.|::.:.:|  .:.:..|..|.|||:|.||..|||.|.|:.|..||:..:|.::||||||:
Human    66 RFLEDEMQNEIVV--QLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELK 128

  Fly   131 KVLENTQGFFSDQ-----EVLNLDSSN----RAGGDNDAAAQHRGRLGFVAGVINRERVFAFERM 186
            .:|:.||.||..:     :....|:|.    :|     ..|...|:|||:||||||||:.:|||:
Human   129 YLLKKTQDFFETETNLADDFFTEDTSGLLELKA-----VPAYMTGKLGFIAGVINRERMASFERL 188

  Fly   187 LWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSH 251
            ||||.||||:||.|::|.||.||.|...|.|.:|:.|:|||||:.:|||:|.||.|::||||...
Human   189 LWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPA 253

  Fly   252 NEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTK 316
            .||.||:.:|..|||||..|::|||.||.|:|...:.|..||.|.|:||||:||.||:.|:|||:
Human   254 VERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQ 318

  Fly   317 KCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAY 381
            :|:|.|.|.|..|...:::||..|....||::...:..:.:...|||||||||||.||||::|||
Human   319 QCVIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAY 383

  Fly   382 GVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGG 446
            ||.||||.|||.||.|||||||||||||.|||.:::|...||:|.||:|...:...||||.||.|
Human   384 GVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHG 448

  Fly   447 RYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRW-----FNN--YNTTTVLTNPNLQLPPNSSAV- 503
            ||:|||||:|::||||:|||.||||:|:|||.|     |.|  :||..:..:..|||.|....|
Human   449 RYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIPGVY 513

  Fly   504 --GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVP 566
              ..||||:||:|.||.||:.||||:|||:|:|.|::.|||||.:|:.|..:|:|..:|.|:|:|
Human   514 FGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIP 578

  Fly   567 QILFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFE 631
            :::|:|.||||:|||:.|||..::...|..      |||:||.||||.||..::   ..|..:::
Human   579 EMIFILCLFGYLVFMIIFKWCCFDVHVSQH------APSILIHFINMFLFNYSD---SSNAPLYK 634

  Fly   632 SQPQLQKAFVLIALCCIPWMLLGKPLYIKFT-RKNKAHANH-NGQLTGNIELAEGETPLPTGFSG 694
            .|.::|..||::||..:|||||.||..::.: ||::..|:. ....|.||   ||::..|:..||
Human   635 HQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENI---EGDSSSPSSRSG 696

  Fly   695 NEENA---GGAHGHDDE-PMSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQM 755
            ...:|   |....|.:| ...::::|||||||||.|..||:||||||||||||||||||||||.|
Human   697 QRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTM 761

  Fly   756 VLSLGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQ 820
            |::.||:..|.||.:|:||||..:.:.|:|||::|||||||||.||||||||.:|||.|.||.|.
Human   762 VMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGYKFS 826

  Fly   821 PFSFKAILDGEEEE 834
            |||||.||||..||
Human   827 PFSFKHILDGTAEE 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	27..824	CDD:460232	417/821 (51%)
ATP6V0A4	NP_065683.2	V_ATPase_I	27..830	CDD:460232	417/821 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..704		9/31 (29%)