DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-2 and Vha100-4

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	833	Identity:	548/833 - (65%)
Similarity:	666/833 - (79%)	Gaps:	6/833 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKIRYI 68
            :||||.|:|.||::||||||.:::.|||.|||||||||..:||.||||:.||||||||||:|||:
  Fly    16 IFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRYV 80

  Fly    69 ETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELRKVL 133
            ..|:.|:|..:.|:.||.|.||.||||||||.||||||:|::|||.|.||::::||||:|:.:||
  Fly    81 TAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQVL 145

  Fly   134 ENTQGFFSDQEVLNLDSSNRAGGDNDAAAQHRGRLGFVAGVINRERVFAFERMLWRISRGNVFLK 198
            |.|..||||||..|.| .|:.|...| ..:..|.||||||||:|||.:|||||||||||||||::
  Fly   146 ERTDQFFSDQESHNFD-LNKMGTHRD-PEKSNGHLGFVAGVISREREYAFERMLWRISRGNVFVR 208

  Fly   199 RSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNEREEMVRNVRT 263
            |.|:|..|.||.||:.::|:|||.||||:||:.||:||||||||.:|||||||:||:|||:||||
  Fly   209 RCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSERQEMVKNVRT 273

  Fly   264 RLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKCLIGECWVPTN 328
            |||||:::::||.|||:.||....|.||:||.||||||.|||||||||:|:..||||||.|||..
  Fly   274 RLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKCLIGEGWVPKR 338

  Fly   329 DLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGVASYRECNPAL 393
            :|.:|:.||:.|||:||||:|||:||:||.::|||..|||||||||||||||||:|.|||.||.|
  Fly   339 ELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGIAGYREVNPGL 403

  Fly   394 YTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRYIILLMGLFAM 458
            ||||||||||||||||:|||.||.|.|.|||:.|::|:: :.|||||||||.|||||:|||||||
  Fly   404 YTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLSK-KRGGEIWNIFFAGRYIIMLMGLFAM 467

  Fly   459 YTGLVYNDVFSKSMNLFGSRWFNNYNTTTVLTNPNLQLPPNSSAVGVYPFGMDPVWQLADNKIIF 523
            |||..|||:||||:|:||:||.|.||.|||||||.|||.|:.:..||||.|:||:||.|.|||||
  Fly   468 YTGFHYNDIFSKSINVFGTRWVNVYNRTTVLTNPTLQLNPSVATRGVYPMGIDPIWQSASNKIIF 532

  Fly   524 LNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQILFLLLLFGYMVFMMFFKWFS 588
            ||::|||||||||||||||||||||.||..||:||.|.|:||||:|||||:||||.||||:||..
  Fly   533 LNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVPQVLFLLLMFGYMCFMMFYKWVK 597

  Fly   589 YNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQPQLQKAFVLIALCCIPWMLL 653
            |:..|..:.:|||||||||||||:|:|||......||:..||..|..|:..|:::||.||||:||
  Fly   598 YSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNMFPIQKNLEMIFLVVALLCIPWILL 662

  Fly   654 GKPLYIKFTRKNK--AHANHNGQLTGNIELAEGETPLPTGFSGNEENAGGAHGHDDEPMSEIYIH 716
            |||||||:.|:|:  .......::...||:..|:..:.|..:...| :||....||||||||:||
  Fly   663 GKPLYIKYQRRNRPAGPVEEVDEIVEKIEVTTGKEIIITEVAEAHE-SGGHSEEDDEPMSEIWIH 726

  Fly   717 QAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVLSLGLKMSGVGGAIGLFIIFGAWCL 781
            ||||||||:||||||||||||||||||||||||||||.|||::||:|:|..||||||.||..|..
  Fly   727 QAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLWTMVLAMGLQMNGYVGAIGLFFIFAVWEF 791

  Fly   782 FTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQPFSFKAILDGEEEE 834
            ||:||:|:|||||||||||||||||||||||.|.||.|.|||||.||...|::
  Fly   792 FTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGYPFTPFSFKDILIVVEDD 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	528/797 (66%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	524/791 (66%)
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	544/822 (66%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	528/797 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451287
Domainoid	1	1.000	601	1.000	Domainoid score	I37
eggNOG	1	0.900	-	-		E1_COG1269
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I211
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm1001
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	P	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
	11	10.800