DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-2 and Vha100-5

DIOPT Version :9

Sequence 1:	NP_650722.1	Gene:	Vha100-2 / 42216	FlyBaseID:	FBgn0028670	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	841	Identity:	549/841 - (65%)
Similarity:	667/841 - (79%)	Gaps:	34/841 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            ||||||||:|||||:||||||||.|::||||.|||||||||..|:|||||:|.||||||::||::
  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65

  Fly    66 RYIETEIKKDGIVLPDIQ-DDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTEL 129
            ||:|:|:|||.:.||.:: ::.|.|||||||:||||.||||::|:.|::.|..::.:|:..:.||
  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130

  Fly   130 RKVLENTQGFFSDQEVLNLDSSNRAGGDNDA---AAQHRGRLGFVAGVINRERVFAFERMLWRIS 191
            :.|||||:||||||||:|||.:.:...::.|   .|..||:|.||||||..||.|:|||||||||
  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDPEDPANLPGAAQRGQLAFVAGVIKLERFFSFERMLWRIS 195

  Fly   192 RGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNEREE 256
            |||:||:|:|:|..:.|..||.|:.||||||||||||||.||||||||:||::|||||||.||:|
  Fly   196 RGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCPSSHAERKE 260

  Fly   257 MVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKCLIG 321
            |:::|..|||||||||||:.|||||||.:.||:||.|||||:|||||||.||.||.|||.|||||
  Fly   261 MIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPDVTGKCLIG 325

  Fly   322 ECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGVASY 386
            |.||||||:..||.||:..|....|:||:|:|||:|||.|||:.||||||.|||||:|:||:|||
  Fly   326 EGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLVDSYGMASY 390

  Fly   387 RECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRYIIL 451
            ||.|||||.|||||||||||||||||||||:||.:|:::.|::|:.|:.  ||:||||||||||.
  Fly   391 REVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSSIKE--EIFNIFFGGRYIIF 453

  Fly   452 LMGLFAMYTGLVYNDVFSKSMNLFGSRWFNNYNTTTVLTNPNLQ---LPPNSSAVGVYPFGMDPV 513
            |||:|::|||.:||||||||||:|||.|..|| |..|:.:.||:   |.||.:....|||||||:
  Fly   454 LMGIFSIYTGFIYNDVFSKSMNIFGSAWHMNY-TRDVVEDENLKYITLRPNDTVYKTYPFGMDPI 517

  Fly   514 WQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQILFLLLLFGYM 578
            ||||||||||||:||||||||.||:||:|||.||||||.::|:||||||||:||:||||||||||
  Fly   518 WQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEFLPQVLFLLLLFGYM 582

  Fly   579 VFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQPQLQKAFVLI 643
            ||||||||..|| .|...|.:|.||||:||:||||:|..:.:.|:.|.||||:.|..:|:.||::
  Fly   583 VFMMFFKWVVYN-DTVEGPLSPACAPSILILFINMILQGSQDTPEPCKEFMFDGQKSIQQVFVVV 646

  Fly   644 ALCCIPWMLLGKPLYIKFTRKNKAHANHNGQLTGNIELAEGETPLPTGFSGNEENAGGAHGHDDE 708
            |:.|||||||||||||...||.      ||            .|.|...||    .|..||.|||
  Fly   647 AIICIPWMLLGKPLYIMIKRKT------NG------------APPPKPQSG----GGEGHGEDDE 689

  Fly   709 PMSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVLSLGLKMSGVGGAIGLF 773
             |.||:||||||||||||||:||||||||||||||||||||||||.||.|:|.|.....|.|.::
  Fly   690 -MGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMVFSMGFKYDSYIGGILIY 753

  Fly   774 IIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQPFSFKAILDGEEEE 834
            :.||||.|.|:.||||:||||||||||||||||||||||||.||||:||:||.|||..|::
  Fly   754 VFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAFEPFAFKTILDVSEDD 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	28..824	CDD:279793	521/802 (65%)
Vha100-2	NP_650722.1	NtpI	35..825	CDD:224188	515/796 (65%)
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	539/826 (65%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	521/802 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451289
Domainoid	1	1.000	601	1.000	Domainoid score	I37
eggNOG	1	0.900	-	-		E1_COG1269
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I211
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm1001
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	P	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
	12	11.750