Protein Alignment Vha100-2 and Atp6v0a4

DIOPT Version :10

• Sequence 1: NP_650722.1
• Gene: Vha100-2 / 42216
• FlyBaseID: FBgn0028670
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: NP_001402767.1
• Gene: Atp6v0a4 / 296981
• RGDID: 1305055
• Length: 829
• Species: Rattus norvegicus
• Alignment Length: 856
• Identity: 441/856 - (51%)
• Similarity: 580/856 - (67%)
• Gaps: 49/856 - (5%)

  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65
            |..:||||||.|.|:|:|.||||..|:||||.|.|||:|||.|||:||||||.|||||:.|||.:
  Rat     1 MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130
            |::|.|::.:.|:  .:.|..|..|.|||:|.||..|||.|.|:.|..|:...:|.::||||||:
  Rat    66 RFLEDEMQNEIII--QVPDKDPGTPLPREMITLETTLEKLEGELQEANQSHQALKKSFLELTELK 128

  Fly   131 KVLENTQGFFSDQEVLNLDSSNRAGGDNDAAAQHR-------GRLGFVAGVINRERVFAFERMLW 188
            .:|:.||.||..:..|..|....   |.....:.|       |:|||.||||||||:.:|||:||
  Rat   129 YLLKKTQDFFETETNLGEDFFVE---DTSGLLELRAMPAFMTGKLGFTAGVINRERMASFERLLW 190

  Fly   189 RISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGFHASLYPCPSSHNE 253
            |:.||||:||.|::|..|.||.|...|.|.:|:.|:|||||:.:|||:|.||.|::||||....|
  Rat   191 RVCRGNVYLKFSEMDTLLEDPVTKEEIKKNIFIIFYQGEQLRLKIKKICDGFRATIYPCPEHAAE 255

  Fly   254 REEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYHTLNLFNMDVTKKC 318
            |.||:.:|..|||||..|::|||.||.|:|...:.|..||.|.|:||||:||.||:.|:|||::|
  Rat   256 RREMLASVNVRLEDLITVITQTESHRQRLLQEAASNWHSWVIKVQKMKAVYHVLNMCNIDVTQQC 320

  Fly   319 LIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKFTRGFQNLIDAYGV 383
            :|.|.|.|..|...::|||..|....||::...:..::|...|||||||||||.||||::|||||
  Rat   321 IIAEIWFPVADTRHIKKALEQGMELSGSSMVPIMTEVETKTDPPTFNRTNKFTAGFQNIVDAYGV 385

  Fly   384 ASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRNGGEIWNIFFGGRY 448
            .||||.|||.||.|||||||||||||.|||:::::...||||.||.|...::..|:|||||.|||
  Rat   386 GSYREINPAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLNERHLLAQKSTNEMWNIFFNGRY 450

  Fly   449 IILLMGLFAMYTGLVYNDVFSKSMNLFGSRW-----FNN--YNTTTVLTNPNLQLPPNSSAV--- 503
            :|||||:|::||||:|||.||||.|:|||.|     |.|  :|...|..||.|||.|....|
  Rat   451 LILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWNAHVVEQNPYLQLDPAIPGVYSG 515

  Fly   504 GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKRYASIFLEFVPQI 568
            ..||||:||:|.||.||:.||||:|||:|:|.|::||:|||.:|:.|..:|:|..:|.|:|:|::
  Rat   516 NPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVHMIFGVILSLFNHIYFRRTLNIILQFIPEM 580

  Fly   569 LFLLLLFGYMVFMMFFKWFSYNARTSFQPETPGCAPSVLIMFINMMLFKNTEPPKGCNEFMFESQ 633
            :|:|.||||:|||:.|||..|:|.||.:      |||:||.||.|.||...:   ..|..::..|
  Rat   581 IFMLSLFGYLVFMIIFKWCQYDAHTSQK------APSILIHFIGMFLFDYDD---SSNAPLYGHQ 636

  Fly   634 PQLQKAFVLIALCCIPWMLLGKPLYIKFTRKNKAHANHNGQLTGNIELAEGETPLPTGFSGNEEN 698
            .::|..||:|||..:|||||.||..::        |.|......:..:.|.....|     :.:.
  Rat   637 QEVQTFFVIIALVSVPWMLLIKPFILR--------AKHQKSQLQSFTIHEDAMEGP-----SVKK 688

  Fly   699 AGGAH----GHDDE-PMSEIYIHQAIHTIEYVLSTISHTASYLRLWALSLAHAQLSEVLWQMVLS 758
            ..|||    ||::| ...:|::|||||||||.|..||:|||||||||||||||:||||||.||:|
  Rat   689 TAGAHGTKEGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWTMVMS 753

  Fly   759 LGLKMSGVGGAIGLFIIFGAWCLFTLAILVLMEGLSAFLHTLRLHWVEFMSKFYEGMGYAFQPFS 823
            :||::.|.||.:|:||||..:.:.|:|||::|||||||||.||||||||.:|||||.|:.|.|||
  Rat   754 IGLRLRGWGGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYEGAGFKFSPFS 818

  Fly   824 FKAILDGEEEE 834
            ||.:|:|..||
  Rat   819 FKHVLEGAAEE 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-2	NP_650722.1	V_ATPase_I	27..824	CDD:460232	418/818 (51%)
Atp6v0a4	NP_001402767.1	V_ATPase_I	27..819	CDD:460232	418/818 (51%)